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A '''psychoactive substance''' is defined as a chemical substance, other than a nutrient or essential dietary ingredient, that affects nerve function to produce alterations in sensation, perception, mood, consciousness, cognition, and behavior.  
A '''psychoactive substance''' is a chemical substance—other than a nutrient or essential dietary ingredient—that alters brain function to produce temporary changes in sensation, perception, mood, consciousness, cognition, and behavior.  


Psychoactive substances are used for a number of purposes; for example, they can be taken recreationally for their novelty and [[euphoria|euphoric]] effects, as [[entheogens]] for ritual or spiritual purposes, or as tools for augmenting and studying the mind. Many psychoactive substances have demonstrable therapeutic utility and are used in routine medical practice (e.g. [[pain relief|anaesthetics]], analgesics, [[anxiety suppression|anxiolytics]], [[antidepressants]], etc.).
Psychoactive substances have been used by humans for a variety of purposes since recorded history. For example, they may be used as medicine, as recreational substances for their euphoric effects and novelty value, as [[entheogens]] for ritual or spiritual purposes, or as scientific research probes for studying the brain and mind. The latter two have particular relevance for practitioners of [[psychonautics]].


The ''psychoactive substance index'' serves to catalog and provide relevant, accurate, and unbiased information for any and all psychoactive substances, with a special focus on those that can be used as tools for expanding consciousness. The individual articles detail not just the chemistry, pharmacology, toxicity and harm potential of each substance, but also its subjective effects. This is done by following a standardized system of definitions and terminologies that can be found in the [[subjective effects index]].
The '''''Psychoactive Substance Index''''' ('''PSI''') is designed to catalog and provide relevant, accurate, and unbiased information for any and all mind-altering substances known to humankind, with a special focus on those with potential applications as mind-expanding tools.  
 
The individual articles detail not just the history, chemistry, pharmacology, toxicity, and legality of each substance, but also its user-reported subjective effects (i.e. phenomenology). This is achieved in accordance with a standardized system of definitions and terminologies proposed in the [[subjective effect index|'''''Subjective Effect Index''''']] ('''SEI''').


'''Please see our [[summary index]] to view conveniently condensed versions of each article.'''
'''Please see our [[summary index]] to view conveniently condensed versions of each article.'''
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'''Note:''' This list should only include substances that have a ''documented history of human use''. Do not include substances that are merely theoretical or lack reliable user experience reports and data!