Methcathinone: Difference between revisions

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~~{{headerpanel|{{approval}}}}~~

'''Methcathinone''' (also known as '''Ephedrone~~''' originally, '''Methcat~~''' and '''~~CAT~~''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.

'''Methcathinone''' (also known as '''Ephedrone''' and '''MCAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.

Methcathinone was first ~~synthesised~~ in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].

==History and culture==

Methcathinone was first synthesized in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].

==Chemistry==

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==Toxicity and harm potencial==

===Neuro toxicity===

Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>

===Dependence and abuse potential===

Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

~~====Dosing====~~

It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].

~~Some people may also advice to tapper the comedown of a high dose, with a low dose after approximately an hour.~~

~~==Synthesis==~~

Methcathinone is synthesised most easily by reacting Pseudoephedrine with potassium permanganate, although dichromate may also be used as a oxidizer. The reaction is quite unstable and needs to be held at specifically -15 Celsious, so that the oxidation is subtle and not too energetic, turning Pseudoephedrine into Benzaldehyde. The same goes for the amount of potassium permanganate, it has to be a specific ratio of oxidizer to Pseudoephedrine.

~~[[File:synth.png|800px]]~~

==Legal status==

Internationally, methcathinone is a Schedule I controlled substance.~~{{citation needed}}~~

Internationally, methcathinone is a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances.<ref>https://www.incb.org/incb/en/psychotropics/green-list.html</ref>

*'''Australia''': Methcathinone is a Schedule 9 controlled substance.<ref>{{cite web|url=https://www.legislation.gov.au/Details/F2019L01471|title=POISONS STANDARD DECEMBER 2019|publisher=Office of Parliamentary Counsel|access-date=December 19, 2019}}</ref>

==See also==

*[[Responsible use]]

*[[Stimulants]]

*[[Substituted cathinone|Cathinones]]

*[[Amphetamine]]

*[[Mephedrone]]

*[[3-MMC]] ~~(''3-methylmethcathinone'')~~

*[[3-MMC]]

*[[Ethcathinone]]

*[[~~Pseudoephidrine~~]]

*[[Pseudoephedrine]]

===Experience reports===

{{Experience reports|erowid_experience_substance_label=Methcathinone}}

~~Anecdotal reports which describe the effects of this compound within our [[experience index]] include:~~

{{~~#ask: [[Category:Methcathinone]][[Category:~~Experience reports]]|~~format~~=~~ul|Columns=1~~}}

*[https://erowid.org/experiences/subs/exp_Methcathinone.shtml Erowid Experience Vaults: Methcathinone]

==External links==

*[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]

*[https://erowid.org/chemicals/cathinone/ Cathinone & Methcathinone (Erowid Vault)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]

*[https://~~www~~.~~reddit~~.com/r/Methcathinone~~/ Methcathinone Subreddit~~]

*[https://go.drugbank.com/drugs/DB15339 Methcathinone (DrugBank)]

==References==

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[[Category:Stimulant]]

[[Category:Proofread]]

[[Substitutions::H,H,H,H,H,CH<sub>3</sub>,H]]

@@ Line 1: / Line 1: @@
-{{headerpanel|{{approval}}}}
 {{SummarySheet}}
 {{SubstanceBox/Methcathinone}}
-'''Methcathinone''' (also known as '''Ephedrone''' originally, '''Methcat''' and '''CAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.
+'''Methcathinone''' (also known as '''Ephedrone''' and '''MCAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.
-Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].
+==History and culture==
+Methcathinone was first synthesized in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].
 ==Chemistry==
@@ Line 68: / Line 68: @@
 ==Toxicity and harm potencial==
 ===Neuro toxicity===
 Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
 ===Dependence and abuse potential===
 Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
-====Dosing====
-It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].
-Some people may also advice to tapper the comedown of a high dose, with a low dose after approximately an hour.
-==Synthesis==
-Methcathinone is synthesised most easily by reacting Pseudoephedrine with potassium permanganate, although dichromate may also be used as a oxidizer. The reaction is quite unstable and needs to be held at specifically -15 Celsious, so that the oxidation is subtle and not too energetic, turning Pseudoephedrine into Benzaldehyde. The same goes for the amount of potassium permanganate, it has to be a specific ratio of oxidizer to Pseudoephedrine.
-[[File:synth.png|800px]]
 ==Legal status==
-Internationally, methcathinone is a Schedule I controlled substance.{{citation needed}}
+Internationally, methcathinone is a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances.<ref>https://www.incb.org/incb/en/psychotropics/green-list.html</ref>
 *'''Australia''': Methcathinone is a Schedule 9 controlled substance.<ref>{{cite web|url=https://www.legislation.gov.au/Details/F2019L01471|title=POISONS STANDARD DECEMBER 2019|publisher=Office of Parliamentary Counsel|access-date=December 19, 2019}}</ref>
 ==See also==
 *[[Responsible use]]
 *[[Stimulants]]
 *[[Substituted cathinone|Cathinones]]
-*[[Amphetamine]]
 *[[Mephedrone]]
-*[[3-MMC]] (''3-methylmethcathinone'')
+*[[3-MMC]]
 *[[Ethcathinone]]
-*[[Pseudoephidrine]]
+*[[Pseudoephedrine]]
 ===Experience reports===
+{{Experience reports|erowid_experience_substance_label=Methcathinone}}
-Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
-{{#ask: [[Category:Methcathinone]][[Category:Experience reports]]|format=ul|Columns=1}}
-*[https://erowid.org/experiences/subs/exp_Methcathinone.shtml Erowid Experience Vaults: Methcathinone]
 ==External links==
 *[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]
-*[https://erowid.org/chemicals/cathinone/ Cathinone & Methcathinone (Erowid Vault)]
 *[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]
-*[https://www.reddit.com/r/Methcathinone/ Methcathinone Subreddit]
+*[https://go.drugbank.com/drugs/DB15339 Methcathinone (DrugBank)]
 ==References==
@@ Line 130: / Line 105: @@
 [[Category:Stimulant]]
 [[Category:Proofread]]
+[[Substitutions::H,H,H,H,H,CH<sub>3</sub>,H]]