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'''Methcathinone''' (also known as '''Ephedrone''' originally, '''Methcat''' and '''CAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.
'''Methcathinone''' (also known as '''Ephedrone''' and '''MCAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.


Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].
==History and culture==
Methcathinone was first synthesized in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].


== Chemistry ==
==Chemistry==
Methcathinone is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain containing a beta-ketone group (what is known as a '''cathinone''' molecule) with an additional methyl substitution at R<sub>α</sub>. It can be thought of as the cathinone homolog of [[methamphetamine]] as it has the same general formula, differing only in the addition of a single double bonded oxygen.
Methcathinone is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain containing a beta-ketone group (what is known as a '''cathinone''' molecule) with an additional methyl substitution at R<sub>α</sub>. It can be thought of as the cathinone homolog of [[methamphetamine]] as it has the same general formula, differing only in the addition of a single double bonded oxygen.


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*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effects::Cognitive euphoria - Methcathinone is extremely stimulating and energetic.]]'''
*'''[[Effects::Cognitive euphoria]]''' - Methcathinone is extremely stimulating and energetic.
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
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== How to Dose Properly ==
==Toxicity and harm potencial==
Methcathinone, due to its nature, can often cause extreme compulsive redosing. A good strategy is to pre-plan your experience in advance.
===Neuro toxicity===
To minimalize the risk of compulsive redosing and severe negative effects, follow the below points:
Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
▹Pre-plan the total amount of Methcathinone you will take. Limit the amount you have accessible to that amount.
▹Make a rough timeline of the experience. Plan how many re-doses you will do and when you will re-dose.


===Dependence and abuse potential===
Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].


0When you take a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose. So you don't comedown.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.


Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell. Gradually decreasing the dose instead aka a redose will make it a ton more manageable.  
==Legal status==
You can then redose another 40% or leave it. But '''don't''' redose more than twice.0
Internationally, methcathinone is a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances.<ref>https://www.incb.org/incb/en/psychotropics/green-list.html</ref>


0What I recommend for the comedown is that 60mins after you redosed last to take 20% of the first dose.  
*'''Australia''': Methcathinone is a Schedule 9 controlled substance.<ref>{{cite web|url=https://www.legislation.gov.au/Details/F2019L01471|title=POISONS STANDARD DECEMBER 2019|publisher=Office of Parliamentary Counsel|access-date=December 19, 2019}}</ref>
Then to stop. That's the best method to not have a huge comedown.0
 
0For a mild stimulating experience, take a light dose first, then redose with a medium dose, then as a final, a medium or medium-high dose. Space the doses out more.0
 
== Synthesis ==
 
Methcathinone is synthesised most easily by reacting Pseudoephedrine with KMnO4. The reaction is very specific though. A very specific temperature needs to be achieved, below zero, so that the oxidation is subtle and not too energetic, so that it does not destroy the Pseudoephedrine and make it into Benzaldehyde. The same goes for the amount of KMnO4, it has to be a specific ratio of oxidizer to Pseudoephedrine.
 
[[File:synth.png|1740px]]


==See also==
==See also==
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*[[Stimulants]]
*[[Stimulants]]
*[[Substituted cathinone|Cathinones]]
*[[Substituted cathinone|Cathinones]]
*[[Amphetamine]]
*[[Mephedrone]]
*[[Mephedrone]]  
*[[3-MMC]]
*[[3-MMC]] (''3-methylmethcathinone'')
*[[Ethcathinone]]
*[[Ethcathinone]]
*[[Pseudoephedrine]]


 
===Experience reports===
=== Experience reports ===
{{Experience reports|erowid_experience_substance_label=Methcathinone}}
 
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:Methcathinone]][[Category:Experience reports]]|format=ul|Columns=1}}
*[https://erowid.org/experiences/subs/exp_Methcathinone.shtml Erowid Experience Vaults: Methcathinone]
 


==External links==
==External links==
*[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]
*[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]
*[https://erowid.org/chemicals/cathinone/ Cathinone & Methcathinone (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]
*[https://www.reddit.com/r/Methcathinone/ Methcathinone Subreddit]
*[https://go.drugbank.com/drugs/DB15339 Methcathinone (DrugBank)]


==References==
==References==
<references/>
{{reflist|2}}
 
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Cathinone]]
[[Category:Cathinone]]
[[Category:Stimulant]]
[[Category:Stimulant]]
[[Category:Proofread]]
[[Substitutions::H,H,H,H,H,CH<sub>3</sub>,H]]
Retrieved from "http://psy.st/wiki/Methcathinone"