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'''Methcathinone''' (also known as '''Ephedrone''', '''Methcat''', '''CAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.
'''Methcathinone''' (also known as '''Ephedrone''' and '''MCAT''') is a synthetic [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] chemical class. It produces standard [[amphetamine|amphetamine-like]] stimulant effects. It is similar to the [[cathinone]] compounds found in the [[khat]] plant of eastern Africa and [[mephedrone]] in its structure and effects.


Methcathinone was first synthesised in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].
==History and culture==
Methcathinone was first synthesized in 1928 in the USA and it was used in the Soviet Union as an antidepressant. It is common in central and eastern Europe, often sold as the more well known [[mephedrone]] or synthesized from OTC drugs containing [[ephedrine]] or [[pseudoephedrine]].


== Chemistry ==
==Chemistry==
Methcathinone is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain containing a beta-ketone group (what is known as a '''cathinone''' molecule) with an additional methyl substitution at R<sub>α</sub>. It can be thought of as the cathinone homolog of [[methamphetamine]] as it has the same general formula, differing only in the addition of a single double bonded oxygen.
Methcathinone is comprised of a [[phenethylamine]] core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain containing a beta-ketone group (what is known as a '''cathinone''' molecule) with an additional methyl substitution at R<sub>α</sub>. It can be thought of as the cathinone homolog of [[methamphetamine]] as it has the same general formula, differing only in the addition of a single double bonded oxygen.


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*'''[[Effects::Stimulation]]''' - Methcathinone is reported to be extremely stimulating and energetic. The style of stimulation can be described as "forced". This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily body shakes and vibrations become present.
*'''[[Effects::Physical euphoria]]''' - Physical euphoria is very prominent when used responsibly (i.e. reasonable dosing and spacing between experiences) and can lead to profound feelings of social and physical disinhibition.''
*'''[[Effect::Dehydration]]''' - The '''Dehydration''' that is experienced during a methcathinone experience is generally '''more severe''' than with other stimulants like Amphetamine. Due to this, you must take extreme care and '''hydrate yourself constantly''', so that you do not suffer from [https://en.wikipedia.org/wiki/Rhabdomyolysis '''Rhabdomyolysis''']. This is done generally by observing your body, if there is any pain, if your kidneys feel weird, and if your urine is yellow to green-yellow like tea. Read the wiki and inform yourself on rhabdomyolysis since it is a very bad thing to have, you could die from it if it is severe enough and untreated over long time. Generally you can mitigate it by seeing if your urine is yellow, then if it is, and you do not urinate regularly '''drink a glass of water every 15 or 30 minutes''' (as long as you don't drink too much and hurt yourself) and your urine should become clear. As Long as you keep hydrating yourself your kidneys will be normal and functioning and you will be good, keep drinking water constantly after it becomes clear, for some few more hours but a bit less amount wise so that you don't have the problem again.
*'''[[Effect::Dehydration]]''' - The '''Dehydration''' that is experienced during a methcathinone experience is generally '''more severe''' than with other stimulants like Amphetamine. Due to this, you must take extreme care and '''hydrate yourself constantly''', so that you do not suffer from [https://en.wikipedia.org/wiki/Rhabdomyolysis '''Rhabdomyolysis''']. This is done generally by observing your body, if there is any pain, if your kidneys feel weird, and if your urine is yellow to green-yellow like tea. Read the wiki and inform yourself on rhabdomyolysis since it is a very bad thing to have, you could die from it if it is severe enough and untreated over long time. Generally you can mitigate it by seeing if your urine is yellow, then if it is, and you do not urinate regularly '''drink a glass of water every 15 or 30 minutes''' (as long as you don't drink too much and hurt yourself) and your urine should become clear. As Long as you keep hydrating yourself your kidneys will be normal and functioning and you will be good, keep drinking water constantly after it becomes clear, for some few more hours but a bit less amount wise so that you don't have the problem again.
*'''[[Effect::Increased heart rate]]''' - The increase in heart rate is generally '''weaker''' than with other stimulants like Methamphetamine.'''
*'''[[Effect::Increased heart rate]]''' - The increase in heart rate is generally '''weaker''' than with other stimulants like Methamphetamine.'''
*'''[[Effect::Increased perspiration]]''' - The amount of perspiration is '''very high'''. You will sweat extremely easily in hot places and if you do any physical activity. Mixing Methcathinone with DXM will make you drip drops of sweat literally all the time. Hydrate yourself due to this increased perspiration or you will lose a large amount of water very fast.'''
*'''[[Effect::Increased perspiration]]''' - The amount of perspiration is '''very high'''. You will sweat extremely easily in hot places and if you do any physical activity. Mixing Methcathinone with DXM will make you drip drops of sweat literally all the time. Hydrate yourself due to this increased perspiration or you will lose a large amount of water very fast.'''
*'''[[Effect::Increased blood pressure]]''' -  
*'''[[Effect::Increased blood pressure]]''' -  
 
*'''[[Effects::Muscle contractions]]''' - These sudden muscle contractions are experienced '''during''' the '''comedown'''. This is due to the deficiency of Dopamine in the brain, which replicates symptoms to Parkinson's disease. These tremors are '''temporary''' and will subside within a few hours.''
 
*'''[[Effects::Muscle spasms]]''' - Typically occurs during the Comedown. This is due to depletion of Dopamine in the brain.''
 
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of Methcathinone can be characterized as a moderate to extreme euphoric sensation that encompasses the entire body. It is capable of becoming overwhelmingly pleasurable at higher doses. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.'' -  
 
*'''[[Effects::Muscle contractions]]''' - These sudden muscle contractions are experienced '''during''' the '''comedown'''. This is due to the deficiency of Dopamine in the brain, which replicates symptoms to Parkinson's disease. These tremors are '''temporary''' and will subside within a few hours.]]'''
 
 
 
 
 
 
 
*'''[[Effects::Muscle spasms]]''' -  
 
 
 
 
*'''[[Effects::Physical euphoria]]''' -
 
 
 
 
*'''[[Effect::Spontaneous physical sensations]]''' -  
 
 
 
 
*'''[[Effects::Stimulation]]''' -  
 
 
 
 
*'''[[Effects::Stomach cramps]]''' -  
*'''[[Effects::Stomach cramps]]''' -  
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
 
*'''[[Effect::Teeth grinding]]''' - This effect when experienced alongside euphoria can often lead to users mildly or intensely clenching their jaw muscles, sometimes even to the point where the individual’s facial expression begins to change. This is sometimes colloquially called “gurning”[4] and is typically only experienced in common to high dosages.''
 
 
 
*'''[[Effect::Teeth grinding]]''' - This component can be considered to be '''less intense''' when compared with that of [[MDMA]].
 
 
 
 
*'''[[Effect::Vasoconstriction]]''' -  
*'''[[Effect::Vasoconstriction]]''' -  


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*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effect::Anxiety]]'''
*'''[[Effects::Cognitive euphoria]]'''
*'''[[Effects::Cognitive euphoria]]''' - Methcathinone is extremely stimulating and energetic.
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effects::Compulsive redosing]]'''
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
*'''[[Effect::Empathy, love, and sociability enhancement]]''' - This particular effect, although distinct, is far less prominent than the same effect found within traditional [[entactogens]] such as [[MDMA]] or [[2C-B]].
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*'''[[Effect::Time distortion]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effects::Wakefulness]]'''
*'''[[Effects::Wakefulness]]'''
 
*'''[[Effects::Psychosis]]'''
*'''[[Effects::Paranoia]]'''
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== How to Dose Properly ==
==Toxicity and harm potencial==
Methcathinone is amazing if '''used correctly'''. If you misuse it you will feel the compulsive need to redose mainly, and have a mostly negative experience.
===Neuro toxicity===
It has a short peak and then comedown. You need to eighter redose properly to extend it or to leave it alone for today. When you take a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose. So you don't comedown.
Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
 
Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell. Gradually decreasing the dose instead aka a redose will make it a ton more manageable.
You can then redose another 40% or leave it. But '''don't''' redose more than twice.


What I recommend for the comedown is that 60mins after you redosed last to take 20% of the first dose.
===Dependence and abuse potential===
Then to stop. That's the best method to not have a huge comedown.
Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].


== Synthesis ==
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.


Methcathinone is synthesised most easily by reacting Pseudoephedrine with KMnO4. The reaction is very specific though. A very specific temperature needs to be achieved, below zero, so that the oxidation is subtle and not too energetic, so that it does not destroy the Pseudoephedrine and make it into Benzaldehyde. The same goes for the amount of KMnO4, it has to be a specific ratio of oxidizer to Pseudoephedrine.
==Legal status==
Internationally, methcathinone is a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances.<ref>https://www.incb.org/incb/en/psychotropics/green-list.html</ref>


[[File:synth.png|1740px]]
*'''Australia''': Methcathinone is a Schedule 9 controlled substance.<ref>{{cite web|url=https://www.legislation.gov.au/Details/F2019L01471|title=POISONS STANDARD DECEMBER 2019|publisher=Office of Parliamentary Counsel|access-date=December 19, 2019}}</ref>


==See also==
==See also==
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*[[Stimulants]]
*[[Stimulants]]
*[[Substituted cathinone|Cathinones]]
*[[Substituted cathinone|Cathinones]]
*[[Amphetamine]]
*[[Mephedrone]]
*[[Mephedrone]]  
*[[3-MMC]]
*[[3-MMC]] (''3-methylmethcathinone'')
*[[Ethcathinone]]
*[[Ethcathinone]]
*[[Pseudoephedrine]]


 
===Experience reports===
=== Experience reports ===
{{Experience reports|erowid_experience_substance_label=Methcathinone}}
 
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:Methcathinone]][[Category:Experience reports]]|format=ul|Columns=1}}
*[https://erowid.org/experiences/subs/exp_Methcathinone.shtml Erowid Experience Vaults: Methcathinone]
 


==External links==
==External links==
*[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]
*[https://en.wikipedia.org/wiki/Methcathinone Methcathinone (Wikipedia)]
*[https://erowid.org/chemicals/cathinone/ Cathinone & Methcathinone (Erowid Vault)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=2003 Methcathinone (Isomer Design)]
*[https://www.reddit.com/r/Methcathinone/ Methcathinone Subreddit]
*[https://go.drugbank.com/drugs/DB15339 Methcathinone (DrugBank)]


==References==
==References==
<references/>
{{reflist|2}}
 
[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Cathinone]]
[[Category:Cathinone]]
[[Category:Stimulant]]
[[Category:Stimulant]]
[[Category:Proofread]]
[[Substitutions::H,H,H,H,H,CH<sub>3</sub>,H]]
Retrieved from "http://psy.st/wiki/Methcathinone"