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{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/3C-E}}
{{SubstanceBox/3C-E}}


'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although its name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]
'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::Substituted amphetamines|amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case. 3C-E has the structure of [[escaline]], a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.


It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.
3C-E was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.<ref>{{Citation | title=Erowid Online Books : “PIHKAL” - #25 3C-E | url=https://erowid.org/library/books_online/pihkal/pihkal025.shtml}}</ref>


Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.  
Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.  
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==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.
Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.


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|{{effects/physical|
|{{effects/physical|


*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 3C-E is usually considered to be extremely stimulating at levels which are capable of becoming uncomfortable and overwhelming. This can result in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and engage in physical activities. In comparison, other more commonly used psychedelics such as [[psilocin]] are sedating and relaxed.
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 3C-E is usually considered to be moderately to extremely stimulating. In comparison, other more commonly used psychedelics such as [[psilocin]] are sedating and relaxed.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 3C-E is manifested as somewhat intense in comparison to most classical psychedelics such as [[LSD]]. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Some reports also suggest the body high of 3C-E is very challenging even at lower dosages.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 3C-E is manifested as somewhat intense in comparison to most classical psychedelics such as [[LSD]]. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
**'''[[Effect::Physical euphoria]]''' - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.  
**'''[[Effect::Physical euphoria]]''' - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.  
*'''[[Effect::Changes in felt bodily form]]''' <!-- - This effect is often accompanied by a sense of warmth or [[Unity and interconnectedness#Unity between the self and specific external systems|unity]] and usually occurs during and up to the peak of the experience or directly afterward. Users can feel as if they are physically part of or conjoined with other objects. This is usually reported as feeling comfortable in its sensations and even peaceful. -->
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels throughout most 3C-E experiences.  
*'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels.
*'''[[Effect::Nausea]]''' - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
*'''[[Effect::Nausea]]'''
*'''[[Effect::Vasoconstriction]]''' - This effect is usually only present at higher dosages, but can be particularly uncomfortable when it manifests and may persist throughout the main duration of the experience.
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased blood pressure]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
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*'''[[Effect::Teeth grinding]]'''
*'''[[Effect::Teeth grinding]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Salivation]]'''
*'''[[Effect::Increased salivation]]'''
*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}
*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}


}}
}}
{{effects/visual|
{{effects/visual|
The visuals of 3C-E are generally not that apparent and consist more so of distortions than colors and drifting.


====Enhancements====
====Enhancements====
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====Distortions====
====Distortions====
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style. This effect is generally not as powerful as it is with substances like [[mescaline]] or [[DOC]].
*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Depth perception distortions]]''' - This is very common on 3C-E and far objects may appear coming closer to one.
*'''[[Effect::Depth perception distortions]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Perspective distortions]]'''
*'''[[Effect::Symmetrical texture repetition]]''' - This is also very common on 3C-E
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Tracers]]'''
*'''[[Effect::Tracers]]'''
*'''[[Effect::After images]]'''
*'''[[Effect::After images]]'''
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====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[DOC]] or [[mescaline]] than that of [[2C-B]], [[psilocin]] or [[LSD]]. It can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in-depth and consistent in intensity. At higher dosages, this geometry is significantly more likely to result in states of [[Effect::8B Geometry|level 8B]] visual geometry over [[8A Geometry|level 8A]]. The geometry is also described as sometimes becoming very 'yellow'.
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of [[DOC]] or [[mescaline]] than that of [[2C-B]], [[psilocin]] or [[LSD]]. It can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, synthetic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in-depth and consistent in intensity.<!-- At higher dosages, this geometry is significantly more likely to result in states of [[Effect::8B Geometry|level 8B]] visual geometry over [[8A Geometry|level 8A]]. -->


====Hallucinatory states====
====Hallucinatory states====
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*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect:: External hallucinations]]''' - These are often present during the comedown and can include [[shadow people]], among other indescribable beings. These external hallucinations are often lucid, interactive, autonomous, and robust. As [[sleep deprivation]] and [[stimulant psychosis]] surface, a [[trip sitter]] should accompany individuals sensitive to stimulants for the last part of the comedown. The visual effects of psychosis have been reported to blend into the psychedelic visuals around the 6-8 hour mark, sometimes accompanied by auditory hallucinations.


}}
}}
|{{effects/cognitive|
|{{effects/cognitive|


The cognitive effects of 3C-E are described by many as characterized as prominent mental stimulation combined with a powerful amplification of the user's current mental state.
The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.


The total sum of these cognitive components regardless of the setting generally includes:
The total sum of these cognitive components regardless of the setting generally includes:
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*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Increased sense of humor]]'''
**'''[[Effect::Laughter fits]]''' - This can manifest prominently during a 3C-E experience, particularly during the [[Duration#Come up|come up]] phase, often resulting in bouts of uncontrollable giggles and laughter that can form a feedback loop if around others who are also under the influence.
**'''[[Effect::Laughter fits]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Ego death]]'''
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}}
}}
}}
}}
===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].
{{Experience reports|erowid_experience_substance_label=3C-E}}


==Toxicity and harm potential==
==Toxicity and harm potential==
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===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}


*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
==Legal status==
*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
{{legalStub}}
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}


==Legality==
*'''Germany''': 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>
{{legalStub}}
*'''Japan''': 3C-E is a controlled substance in Japan effective March 25th, 2015.<ref>{{Citation | title=危険ドラッグの成分１６物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | language=japanese | url=https://www.mhlw.go.jp/stf/houdou/0000078803.html | access-date=2 May 2022}}</ref>
*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
*'''Switzerland''': 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United States:''' 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>
*'''United States''': 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Psychoactive substance index]]
*[[Psychoactive substance index]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]
*[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]
*[http://drugs.tripsit.me/3c-e 3C-E (TripSit)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=25 3C-E (PiHKAL / Isomer Design)]


==References==
==References==
{{references}}
{{reflist|2}}
{{reflist|2}}


[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Psychedelic]]
[[Category:Amphetamine]]
[[Category:Amphetamine]]
[[Category:Psychedelic]]
[[Category:Research chemical]]
Retrieved from "http://psy.st/wiki/3C-E"