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3C-E: Difference between revisions

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'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although its name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]
'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::Substituted amphetamines|amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case. 3C-E has the structure of [[escaline]], a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.


It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.
3C-E was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.<ref>{{Citation | title=Erowid Online Books : “PIHKAL” - #25 3C-E | url=https://erowid.org/library/books_online/pihkal/pihkal025.shtml}}</ref>


Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.  
Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.  
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==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.
Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.


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|{{effects/cognitive|
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The cognitive effects of 3C-E are described as primarily stimulating and slightly confusing especially at higher dosages.
The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.


The total sum of these cognitive components regardless of the setting generally includes:
The total sum of these cognitive components regardless of the setting generally includes:
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===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].
{{Experience reports|erowid_experience_substance_label=3C-E}}


==Toxicity and harm potential==
==Toxicity and harm potential==
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{{DangerousInteractions/Psychedelics}}
{{DangerousInteractions/Psychedelics}}


==Legality==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
 
*'''United States:''' 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
*'''Germany''': 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>
*'''Japan''': 3C-E is a controlled substance in Japan effective March 25th, 2015.<ref>{{Citation | title=危険ドラッグの成分１６物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | language=japanese | url=https://www.mhlw.go.jp/stf/houdou/0000078803.html | access-date=2 May 2022}}</ref>
*'''Switzerland''': 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>
*'''United States''': 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Psychoactive substance index]]
*[[Psychoactive substance index]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]
*[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=25 3C-E (PiHKAL / Isomer Design)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=25 3C-E (PiHKAL / Isomer Design)]
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[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Psychedelic]]
[[Category:Amphetamine]]
[[Category:Amphetamine]]
[[Category:Psychedelic]]
[[Category:Research chemical]]
Retrieved from "http://psy.st/wiki/3C-E"