3C-E: Difference between revisions

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~~{{headerpanel|{{approval}}{{proofread}}}}~~

'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although ~~its~~ name suggests it may be related to the [[2C-x]] family, this is not the case ~~since it is~~ the ~~3-Carbon analog~~ of [[escaline]]

'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::Substituted amphetamines|amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case. 3C-E has the structure of [[escaline]], a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.

It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.

3C-E was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.<ref>{{Citation | title=Erowid Online Books : “PIHKAL” - #25 3C-E | url=https://erowid.org/library/books_online/pihkal/pihkal025.shtml}}</ref>

Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.

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==Pharmacology==

Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.

Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.

3C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

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*'''[[Effect::Bodily control enhancement]]'''

*'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels.

*'''[[Effect::Nausea]]''' ~~- Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.~~

*'''[[Effect::Nausea]]'''

*'''[[Effect::Vasoconstriction]]''' - This effect is usually only present at higher dosages, but can be particularly uncomfortable when it manifests and may persist throughout the main duration of the experience.

*'''[[Effect::Increased blood pressure]]'''

*'''[[Effect::Increased heart rate]]'''

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*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Increased salivation]]'''

*'''[[Effect::Vasoconstriction]]'''

*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}

}}

{{effects/visual|

The visuals of 3C-E are generally not that apparent and consist more so of distortions than colors and drifting.

====Enhancements====

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====Distortions====

*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style. This effect is generally not as powerful as it is with substances like [[mescaline]] or [[DOC]].

*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])''

*'''[[Effect::Colour shifting]]'''

*'''[[Effect::Depth perception distortions]]'''

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====Hallucinatory states====

~~~~

3C-E and other [[substituted amphetamines]] produce a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used [[psychedelic]]s. This holds particularly true in comparison to other substances within the [[phenethylamines|phenethylamine]] family. These effects include:

*'''[[Effect::Transformations]]'''

*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

*'''[[Effect:: External hallucinations]]''' -

}}

|{{effects/cognitive|

The cognitive effects of 3C-E are described ~~by many~~ as ~~slightly more confusing and introspective~~ than ~~substances like [[2C-B]] or [[DOC]], due~~ to ~~its lack~~ of ~~visual effects~~.

The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.

The total sum of these cognitive components regardless of the setting generally includes:

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}}

===Experience reports===

~~There are currently no anecdotal~~ reports ~~which describe the effects of this compound within our [[experience index]].~~

==Toxicity and harm potential==

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===Dangerous interactions===

*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

==Legal status==

*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}

*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{~~citation needed~~}}

==~~Legality~~==

*'''Germany''': 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>

*'''Japan''': 3C-E is a controlled substance in Japan effective March 25th, 2015.<ref>{{Citation | title=危険ドラッグの成分１６物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | language=japanese | url=https://www.mhlw.go.jp/stf/houdou/0000078803.html | access-date=2 May 2022}}</ref>

*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 ~~(Legislation.gov.uk)~~ | ~~http~~://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>

*'''Switzerland''': 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''United States:''' 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.

*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>

*'''United States''': 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.

==See also==

*[[Responsible use]]

*[[Psychoactive substance index]]

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==External links==

*[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=25 3C-E (PiHKAL / Isomer Design)]

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[[Category:Psychoactive substance]]

[[Category:Psychedelic]]

[[Category:Amphetamine]]

[[Category:~~Psychedelic~~]]

[[Category:Research chemical]]

@@ Line 1: / Line 1: @@
-{{headerpanel|{{approval}}{{proofread}}}}
 {{SummarySheet}}
 {{SubstanceBox/3C-E}}
-'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although its name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]
+'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::Substituted amphetamines|amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case. 3C-E has the structure of [[escaline]], a mescaline analogue, with an additional carbon rendering it a substituted amphetamine.
-It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.
+C-E was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.<ref>{{Citation | title=Erowid Online Books : “PIHKAL” - #25 3C-E | url=https://erowid.org/library/books_online/pihkal/pihkal025.shtml}}</ref>
 Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.
@@ Line 16: / Line 15: @@
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
+Although its name suggests it may be related to the 2C-x family, this is not the case. 3C-E is actually the 3-Carbon analog of escaline, thus the name.
+Its pharmacology can provide strong interaction with 5-HT2A receptors, which could potentially help to prevent cluster headaches or give the compound the possibility to ease the psychological suffering associated with end-stage cancer.
 C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
@@ Line 29: / Line 32: @@
 *'''[[Effect::Bodily control enhancement]]'''
 *'''[[Effect::Tactile enhancement]]''' - Feelings of enhanced tactile sensation are consistently present at low to moderate levels.
-*'''[[Effect::Nausea]]''' - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
+*'''[[Effect::Nausea]]'''
-*'''[[Effect::Vasoconstriction]]''' - This effect is usually only present at higher dosages, but can be particularly uncomfortable when it manifests and may persist throughout the main duration of the experience.
 *'''[[Effect::Increased blood pressure]]'''
 *'''[[Effect::Increased heart rate]]'''
@@ Line 47: / Line 49: @@
 *'''[[Effect::Pupil dilation]]'''
 *'''[[Effect::Increased salivation]]'''
+*'''[[Effect::Vasoconstriction]]'''
 *'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}
 }}
 {{effects/visual|
+The visuals of 3C-E are generally not that apparent and consist more so of distortions than colors and drifting.
 ====Enhancements====
@@ Line 58: / Line 63: @@
 ====Distortions====
-*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and unrealistic/cartoon-like in style. This effect is generally not as powerful as it is with substances like [[mescaline]] or [[DOC]].
+*'''[[Effect::Drifting]]''' ''([[Drifting#Melting|melting]], [[Drifting#Flowing|flowing]], [[Drifting#Breathing|breathing]] and [[Drifting# morphing|morphing]])''
 *'''[[Effect::Colour shifting]]'''
 *'''[[Effect::Depth perception distortions]]'''
@@ Line 72: / Line 77: @@
 ====Hallucinatory states====
-<!--3C-E and other [[substituted amphetamines]] produce a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used [[psychedelic]]s. This holds particularly true in comparison to other substances within the [[phenethylamines|phenethylamine]] family. These effects include:-->
+C-E and other [[substituted amphetamines]] produce a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used [[psychedelic]]s. This holds particularly true in comparison to other substances within the [[phenethylamines|phenethylamine]] family. These effects include:
 *'''[[Effect::Transformations]]'''
 *'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::Alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other [[psychedelic]]s such as [[LSD]], 3C-E is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through its [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
-*'''[[Effect:: External hallucinations]]''' -
 }}
 |{{effects/cognitive|
-The cognitive effects of 3C-E are described by many as slightly more confusing and introspective than substances like [[2C-B]] or [[DOC]], due to its lack of visual effects.
+The cognitive effects of 3C-E are described as primarily stimulating than psychedelic. Higher dosages can lead to a more likely occurence of confusion.
 The total sum of these cognitive components regardless of the setting generally includes:
@@ Line 126: / Line 130: @@
 }}
 }}
 ===Experience reports===
-There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].
+{{Experience reports|erowid_experience_substance_label=3C-E}}
 ==Toxicity and harm potential==
@@ Line 145: / Line 150: @@
 ===Dangerous interactions===
 {{DangerousInteractions/Intro}}
+{{DangerousInteractions/Psychedelics}}
-*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
+==Legal status==
-*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
+{{legalStub}}
-*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
-==Legality==
+*'''Germany''': 3C-E is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 11, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 11, 2019|language=de}}</ref>
-{{legalStub}}
+*'''Japan''': 3C-E is a controlled substance in Japan effective March 25th, 2015.<ref>{{Citation | title=危険ドラッグの成分１６物質を新たに指定薬物に指定 | publisher=厚生労働省 [Ministry of Health, Labour and Welfare (MHLW)] | language=japanese | url=https://www.mhlw.go.jp/stf/houdou/0000078803.html | access-date=2 May 2022}}</ref>
-*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
+*'''Switzerland''': 3C-E can be considered a controlled substance as a defined derivative of a-methylphenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
-*'''United States:''' 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
+*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>
+*'''United States''': 3C-E is technically not scheduled in the United States, but could be considered an analog of [[mescaline]] and may, therefore, be considered a Schedule I drug under the Federal Analogue Act.
 ==See also==
 *[[Responsible use]]
 *[[Psychoactive substance index]]
@@ Line 163: / Line 170: @@
 ==External links==
 *[https://en.wikipedia.org/wiki/3C-E 3C-E (Wikipedia)]
 *[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=25 3C-E (PiHKAL / Isomer Design)]
@@ Line 171: / Line 179: @@
 [[Category:Psychoactive substance]]
+[[Category:Psychedelic]]
 [[Category:Amphetamine]]
-[[Category:Psychedelic]]
+[[Category:Research chemical]]