2C-T: Difference between revisions

'''2,5-Dimethoxy-4-methylthiophenethylamine''' (commonly known as '''2C-T''') is a [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces psychedelic effects when [[Route of administration|administered]].

It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which were derived from the systematic modification of the [[mescaline]] molecule.  

2C-T It was first synthesized and studied through a collaboration between [[David E. Nichols]] and [[Alexander Shulgin]]<ref>Nichols DE, Shulgin AT (October 1976). "Sulfur analogs of psychotomimetic amines". J Pharm Sci. 65 (10): 1554–6. CiteSeerX 10.1.1.687.8486. doi:10.1002/jps.2600651040. PMID 978423.</ref>

It is described in Shulgin's 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="pihkal2CT">Shulgin, A., & Shulgin, A. (1991).</ref>

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has a relatively short history of human usage. It is highly advised to approach this [[hallucinogenic]] substance with the proper amount of precaution and [[harm reduction practices]] if using it.

2C-T is almost unknown on the black market and is rarely sold online.

[[File:Phenethylamine.png|thumb|right|250px|thumb|right|250px||Generic structure of a phenethylamine molecule]]

Being similar in structure to 2C-T-2 and 2C-T-7, this compound may have some MAOI properties.

*'''[[Effect::Spontaneous physical sensations]]''

There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].

Tolerance to the effects of 2C-T are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-T presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-T all psychedelics will have a reduced effect.

Although only speculative, it is worth noting that if 2C-T does have [[MAOI]] effects this could indicate that 2C-T is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelic|serotonergic psychedelics]].<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> This may make it dangerous to combine it with other [[MAOIs]], [[stimulant]]s and certain substances which promotes the release of neurotransmitters such as [[serotonin]] or [[dopamine]]. These substances include but are not limited to:

|  

*'''Canada''': 2C-T would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref>

*'''United Kingdom''': 2C-T is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made</ref>

<references/>