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4-HO-DPT: Difference between revisions

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| ''[[4-HO-DPT/Summary|Summary sheet: 4-HO-DPT]]''
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'''4-HO-DPT''' (also known as '''4-hydroxy-dipropyltryptamine''') is a [[hallucinogen]]ic [[psychoactive class::psychedelic]] drug of the [[chemical class::tryptamine]] class.


Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book [[TiHKAL]] (''Tryptamines I Have Known and Loved''). It is the 4-hydroxyl analog of [[DPT]].<ref>http://www.erowid.org/library/books_online/tihkal/tihkal20.shtml|4-HO-DPT Entry in TIHKAL</ref>.
'''4-HO-DPT''' (also known as '''4-hydroxy-N,N-dipropyltryptamine''' and sometimes referred to as '''Procin''') is a [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book [[TiHKAL]] (''Tryptamines I Have Known and Loved''). It is the 4-hydroxyl analog of [[DPT]].<ref name="TiHKAL">{{cite book|title=TiHKAL: The Continuation|title-link=TiHKAL|last1=Shulgin|first1=Alexander|last2=Shulgin|first2=Ann|author-link1=Alexander Shulgin|year=1997|publisher=Transform Press|location=United States|isbn=0-9630096-9-9|oclc=38503252|chapter-url=https://erowid.org/library/books_online/tihkal/tihkal20.shtml|chapter=#20. 4-HO-DPT}}</ref>


Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.
Today it is either used recreationally or as an [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.
==Chemistry==
==Chemistry==
4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DPT]]).  
4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[DPT]]).  
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==Pharmacology==
==Pharmacology==
{{Main|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
Like with most [[psychedelic]] tryptamines, 4-HO-DPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Like with most [[psychedelic]] tryptamines, 4-HO-DPT is thought to act principally as a [[Serotonin#The_5-HT_system|5-HT<sub>2A</sub>]] [[Agonist#Agonists|partial agonist]]. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT<sub>2A</sub> receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.


==Subjective effects==
==Subjective effects==
The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
{{Preamble/SubjectiveEffects}}


In comparison to other [[tryptamine]]s such as [[4-AcO-DMT]] and [[4-HO-DMT]] it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative [[DPT]]. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as [[psilocin]].  
In comparison to other [[tryptamine]]s such as [[4-AcO-DMT]] and [[4-HO-DMT]], it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative [[DPT]]. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as [[psilocin]].  
===Physical effects===
{{effects/base
*'''[[Effect::Spontaneous tactile sensations]]'''
|{{effects/physical|
*'''[[Effect::Spontaneous physical sensations]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Bodily control enhancement]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
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*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Sublingual numbing]]'''
*'''[[Effect::Mouth numbing]]'''
*'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Muscle relaxation]]'''
*'''[[Effect::Muscle relaxation]]'''


===Cognitive effects===
}}
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Laughter]]'''
*'''[[Effect::Language suppression]]'''
*'''[[Effect::Mindfulness]]'''


===Visual effects===
{{effects/visual|
====Enhancements====
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
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*'''[[Effect::Diffraction]]'''
*'''[[Effect::Diffraction]]'''
*'''[[Effect::Scenery slicing]]'''
*'''[[Effect::Scenery slicing]]'''
===[[Effect::Geometry===
 
====[[Effect::Geometry]]====


====Hallucinatory states====
====Hallucinatory states====
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')


===Auditory effects===
}}
 
|{{effects/cognitive|
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Delusion]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Laughter]]'''
*'''[[Effect::Language suppression]]'''
*'''[[Effect::Mindfulness]]'''
 
}}
 
{{effects/auditory|
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
}}
===Experience reports===
{{Experience reports|erowid_experience_substance_label=4-HO-DPT}}


==Toxicity and harm potential==
==Toxicity and harm potential==
{|  
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
|-
| [[File:Lolol.png|17px]]''Main articles: [[Research chemicals#Toxicity and harm potential|Research chemicals § Toxicity and harm potential]]'' ''&'' ''[[Responsible use #Hallucinogens|Responsible use § Hallucinogens]]''
|}
The toxicity and long-term health effects of recreational 4-HO-DPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-DPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  
The toxicity and long-term health effects of recreational 4-HO-DPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-DPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  


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===Tolerance and addiction potential===
===Tolerance and addiction potential===
4-HO-DPT is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]] it is most often thought to be self-regulating.  
4-HO-DPT is [[Addiction potential::not habit-forming]], and the desire to use it can actually decrease with regular consumption. Like with most [[psychedelics]], it is most often thought to be self-regulating.  


Tolerance to the effects of 4-HO-DPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.
Tolerance to the effects of 4-HO-DPT is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.


==Legal issues==
===Dangerous interactions===
Due to its relative obscurity, the possession and sale of 4-HO-DPT is unscheduled in most countries.
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}


*'''United Kingdom''' - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
==Legal status==
*'''United States''' - 4-HO-DPT is unscheduled in the United States. It may be considered an analog of [[psilocin]] (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or could be prosecuted as crimes under the Federal Analog Act.
Due to its relative obscurity, 4-HO-DPT is unscheduled in most countries.
 
*'''Germany''': 4-HO-DPT is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-HO-DPT are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
*'''Sweden''': 4-HO-DPT is classified as a "dangerous substance"<ref>{{cite web|url=https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2018/februari/tio-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara/|title=Tio nya ämnen kan klassas som narkotika eller hälsofarlig vara|language=sv|publication-date=February 14, 2018|publisher=Folkhälsomyndigheten [Public Health Agency of Sweden]|access-date=August 24, 2020}}</ref>, which means it requires a special permit to buy or sell. It is, however, not yet classified as a drug.
*'''Switzerland''': 4-HO-DPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 4-HO-DPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-HO-DPT is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Research chemical]]
*[[Research chemical]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/4-HO-DPT 4-HO-DPT (Wikipedia)]
*[https://en.wikipedia.org/wiki/4-HO-DPT 4-HO-DPT (Wikipedia)]
*[https://www.erowid.org/library/books_online/tihkal/tihkal20.shtml 4-HO-DPT (Erowid, TiHKAL)]
*[https://isomerdesign.com/PiHKAL/read.php?domain=tk&id=20 4-HO-DPT (TiHKAL / Isomer Design)]
*[http://www.bluelight.org/vb/threads/430916-The-Big-amp-Dandy-4-HO-DPT-Thread 4-HO-DPT (Bluelight)]
*[http://www.bluelight.org/vb/threads/430916-The-Big-amp-Dandy-4-HO-DPT-Thread 4-HO-DPT (Bluelight)]


==References==
==References==
<references/>
<references />
 
[[Category:Substance]]
[[Category:Substance]]
[[Category:Psychoactive substance]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
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{{#set:Featured=true}}
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