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Haloperidol: Difference between revisions

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{{Experience reports|erowid_experience_substance_label=Pharms - Haloperidol}}
 
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{{SummarySheet}}
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'''Haloperidol''' (trade name '''Haldol''') is an [[antipsychotic]] drug used to treat a variety of mental disorders, such as schizophrenia, [[mania]] resulting from bipolar disorder, [[delirium]], [[psychosis]], agitation, Tourette syndrome, as well as hallucinations during alcohol withdrawal. It was first synthesized in 1958 by Paul Janssen<ref>{{cite book | vauthors=((Sneader, W.)) | date=23 June 2005 | title=Drug Discovery: A History | publisher=John Wiley & Sons | isbn=9780471899792}}</ref> from [[meperidine]]<ref>{{cite book | vauthors=((Ravina, E.)) | date=18 April 2011 | title=The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs | publisher=John Wiley & Sons | isbn=9783527326693}}</ref>. Haloperidol is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.<ref>http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref> It is also one of the most frequently prescribed typical antipsychotics and is sometimes carried by medical services as an emergency sedative.
'''Haloperidol''' (trade name '''Haldol''') is an [[antipsychotic]] drug used to treat a variety of mental disorders, such as schizophrenia, [[mania]], bipolar disorder, [[delirium]], [[psychosis]], Tourette syndrome, as well as other disorders. It was first synthesized in 1958 by Paul Janssen<ref>{{cite book | vauthors=((Sneader, W.)) | date=23 June 2005 | title=Drug Discovery: A History | publisher=John Wiley & Sons | isbn=9780471899792}}</ref> from [[meperidine]]<ref>{{cite book | vauthors=((Ravina, E.)) | date=18 April 2011 | title=The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs | publisher=John Wiley & Sons | isbn=9783527326693}}</ref>. Haloperidol is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.<ref>http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref> It is also one of the most frequently prescribed typical antipsychotics and is sometimes carried by medical services as an emergency sedative.


==History and culture==
==History and culture==
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*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Excessive yawning]]'''
*'''[[Effect::Excessive yawning]]'''
*'''[[Effect::Muscle stiffness]]'''
*'''[[Effect::Muscle tension]]'''
*'''[[Effect::Nausea suppression]]'''
*'''[[Effect::Nausea suppression]]'''
*'''[[Effect::Neurotoxicity]]''' - Several lines of evidence suggest that haloperidol exhibits neurotoxicity.<ref name="pmid28738100">{{cite journal | vauthors = Nasrallah HA, Chen AT | title = Multiple neurotoxic effects of haloperidol resulting in neuronal death | journal = Annals of Clinical Psychiatry | volume = 29 | issue = 3 | pages = 195–202 | date = August 2017 | pmid = 28738100 | doi =  }}</ref><ref>{{cite journal | vauthors = Pierre JM | title = Time to retire haloperidol? | journal = Current Psychiatry | volume = 19 | issue = 5 | page = 19 | url = https://www.mdedge.com/psychiatry/article/221293/schizophrenia-other-psychotic-disorders }}</ref>
*'''[[Effect::Physical fatigue]]''' - This effect can sometimes result in an inability to perform tasks such as exercise, walking or even sitting.
*'''[[Effect::Physical fatigue]]''' - This effect can sometimes result in an inability to perform tasks such as exercise, walking or even sitting.
*'''[[Effect::Respiratory depression]]'''
*'''[[Effect::Respiratory depression]]'''
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|{{effects/cognitive|
|{{effects/cognitive|
*'''[[Effect::Apathy]]'''
*'''[[Effect::Cognitive fatigue]]'''
*'''[[Effect::Cognitive fatigue]]'''
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Emotion Suppression]]'''
*'''[[Effect::Emotion suppression]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Focus suppression]]'''
*'''[[Effect::Focus suppression]]'''
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}}
}}
===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
{{Experience reports|erowid_experience_substance_label=Pharms - Haloperidol}}
 
*[https://www.erowid.org/experiences/subs/exp_Pharms_Haloperidol.shtml Erowid Experience Vaults: Haloperidol]


==Toxicity and harm potential==
==Toxicity and harm potential==
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==Legal status==
==Legal status==
*'''Australia:''' The drug is available via prescription only.{{citation needed}}
*'''Australia:''' The drug is available via prescription only.{{citation needed}}
*'''Canada:''' The drug is available via prescription only.{{citation needed}}
*'''Canada:''' The drug is available via prescription only.{{citation needed}}
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==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Antipsychotic]]
*[[Antipsychotic]]
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*[https://isomerdesign.com/PiHKAL/explore.php?id=12029 Haloperidol decanoate (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=12029 Haloperidol decanoate (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=3217 Haloperidol propionate (Isomer Design)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=3217 Haloperidol propionate (Isomer Design)]
*[https://go.drugbank.com/drugs/DB00502 Haloperidol (DrugBank)]
*[https://www.drugs.com/cdi/haloperidol.html Haloperidol (Drugs.com)]
*[https://www.drugs.com/cdi/haloperidol.html Haloperidol (Drugs.com)]


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