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Cocaine/Synthesis: Difference between revisions
>David Hedlund Added sections: ==Legality== and ==External links== |
>David Hedlund ==See also== * Indoor cultivation of coca plants |
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==Legality== | ==Legality== | ||
{{Disclaimer}} | {{Disclaimer}} | ||
Several precursors listed in the recipes below are governed by international treaties, specifically the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances (1988), which mandates control over substances frequently used in the illicit manufacture of narcotic drugs: | |||
* Benzaldehyde | |||
* Methylamine | |||
* Potassium permanganate | |||
==Cocaine Synthesis from "Recreational Drugs" by Professor Buzz== | ==Cocaine Synthesis from "Recreational Drugs" by Professor Buzz== | ||
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Take the total amount of succinaldehyde (obtained from 4 of the above syntheses combined) and without further treatment or purification (this had better be 15.5 g of succindialdehyde) put into an Erlenmeyer flask of 4-5 liters capacity. Add 21.6 g of methylamine hydrochloride, 46.7 g of acetonedicarboxylic acid, and enough water to make a total volume of 2 liters. Adjust the pH to 8-10 by slowly adding a saturated solution of disodium phosphate. The condensate of this reaction (allow to set for about 6 days) is extracted with ether, the ethereal solution is dried over sodium sulphate and distilled, the product coming over at 113°C at 25 mm of pressure is collected. Upon cooling, 14 g of tropinone crystallizes in the pure state. Tropinone can also be obtained by oxidation of tropine with potassium dichromate, but I could not find the specifics for this operation. | Take the total amount of succinaldehyde (obtained from 4 of the above syntheses combined) and without further treatment or purification (this had better be 15.5 g of succindialdehyde) put into an Erlenmeyer flask of 4-5 liters capacity. Add 21.6 g of methylamine hydrochloride, 46.7 g of acetonedicarboxylic acid, and enough water to make a total volume of 2 liters. Adjust the pH to 8-10 by slowly adding a saturated solution of disodium phosphate. The condensate of this reaction (allow to set for about 6 days) is extracted with ether, the ethereal solution is dried over sodium sulphate and distilled, the product coming over at 113°C at 25 mm of pressure is collected. Upon cooling, 14 g of tropinone crystallizes in the pure state. Tropinone can also be obtained by oxidation of tropine with potassium dichromate, but I could not find the specifics for this operation. | ||
===2-Carbomethoxytropinone | ===2-Carbomethoxytropinone=== | ||
A mixture of 1.35 g of sodium methoxide (this is sodium in a minimum amount of methanol), 3.5 g of tropinone, 4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min. Cool to 0°C and add 15 ml of water that contains 2.5 g of ammonium chloride. Extract the solution after shaking with four 50 ml portions of chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil residue in 100 ml of ether, wash twice with a mixture of 6 ml of saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate in vacuo to recover the unreacted tropinone. Take up the oil in a solution of aqueous ammonium chloride and extract with chloroform, dry, and evaporate in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and scratch inside of flask with glass rod to precipitate 2-carbomethoxytropinone. Recrystallize 16 g of this product in 30 ml of hot methyl acetate and add 4 ml of cold water and 4 ml of acetone. Put in freezer for 2.5-3 hours. Filter and wash the precipitate with cold methyl acetate to get pure product. | A mixture of 1.35 g of sodium methoxide (this is sodium in a minimum amount of methanol), 3.5 g of tropinone, 4 ml of dimethylcarbonate and 10 ml of toluene is refluxed for 30 min. Cool to 0°C and add 15 ml of water that contains 2.5 g of ammonium chloride. Extract the solution after shaking with four 50 ml portions of chloroform, dry, evaporate the chloroform in vacuo. Dissolve the oil residue in 100 ml of ether, wash twice with a mixture of 6 ml of saturated potassium carbonate and three ml of 3 N KOH. Dry and evaporate in vacuo to recover the unreacted tropinone. Take up the oil in a solution of aqueous ammonium chloride and extract with chloroform, dry, and evaporate in vacuo to get an oil. The oil is dissolved in hot acetone, cool, and scratch inside of flask with glass rod to precipitate 2-carbomethoxytropinone. Recrystallize 16 g of this product in 30 ml of hot methyl acetate and add 4 ml of cold water and 4 ml of acetone. Put in freezer for 2.5-3 hours. Filter and wash the precipitate with cold methyl acetate to get pure product. | ||
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The tropinones can be used in the above formula (or in a formula that you have found elsewhere) to be converted to cocaine. Remember to recrystallize the 2-Carbomethoxytropinone before converting to methylecgonine. | The tropinones can be used in the above formula (or in a formula that you have found elsewhere) to be converted to cocaine. Remember to recrystallize the 2-Carbomethoxytropinone before converting to methylecgonine. | ||
==See also== | |||
* [[Indoor cultivation of coca plants]] | |||
==External links== | ==External links== | ||
* [https://erowid.org/archive/rhodium/chemistry/cocainesynth.buzz.html | * [https://erowid.org/archive/rhodium/chemistry/cocainesynth.buzz.html Cocaine Synthesis from "Recreational Drugs" by Professor Buzz] (Rhodium archive at Erowid) | ||
[[category:Chemical synthesis]] | [[category:Chemical synthesis]] | ||