Crack cocaine synthesis: Difference between revisions

Retrieved from "http://psy.st/wiki/Crack_cocaine_synthesis"

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+The primary active alkaloid in coca leaves is cocaine, along with other secondary metabolites such as cinnamoylcocaine and benzoylecgonine. Although traditional and modern extraction pathways follow similar logic, they differ significantly in equipment, purity, and process control.
+Raw Material Preprocessing:
+Disrupt plant cell walls to release alkaloid components
+Reduce polyphenol oxidase activity to prevent discoloration from interfering with analysis
+Traditional Method:
+Drying: Air-dry in a cool place or oven-dry until moisture content ≤10%
+Grinding: Coarsely grind to 60 mesh or finer
+Alkalization: Add a weak base (e.g., sodium carbonate or lime) to neutralize acidic plant components
+Soaking: Add a small amount of water, heat to 40–50°C, let stand for 30 minutes
+Extraction of Active Alkaloids (Traditional Pathway):
+Common Solvents: Kerosene, gasoline, coal tar (historically used); modern methods favor organic solvents such as dichloromethane (DCM) or ethyl acetate (EtOAc)
+Detailed Procedure:
+Organic Phase Extraction: Add an appropriate amount of organic solvent (e.g., DCM), stir or sonicate for 30–60 minutes
+Phase Separation: Separate the aqueous and organic layers, repeat 2–3 times to ensure complete extraction
+Acidification Reaction: Add the organic phase to dilute hydrochloric acid to form water-soluble cocaine salt
+Second Phase Separation: Retain the aqueous phase containing the salt, remove residual impurities from the organic phase
+Basification to Free Base: Add sodium hydroxide to convert the salt to freebase cocaine, maintain pH at 9–10
+Final Extraction: Use a non-polar solvent (e.g., ether or hexane) to extract the freebase cocaine
+---
+Modern Method: Microwave-Assisted Extraction (MAE)
+Utilizes microwaves to rapidly heat moisture inside plant tissues, enhancing solvent penetration and diffusion to improve extraction efficiency.
+Starting Material: 10g dried coca leaves
+Solvent Ratio: 1:10 (g:mL)
+Microwave Power: 500W
+Temperature Control: 60°C
+Time: 10–12 minutes
+Extraction Efficiency (crude product): 80–90%
+[Experimental Procedure] Raw Material Preparation:
+Dry 10g of coca leaves, grind to 60–80 mesh
+Prepare 100mL of 50% ethanol–water solution
+Use sodium carbonate (Na₂CO₃) or sodium hydroxide for pre-alkalization (pH 9–10)
+. Pre-Alkalization
+Mix dry powder thoroughly with 1g Na₂CO₃
+Add 10mL distilled water, mix well, let stand for 30 minutes
+. Solvent Addition
+Add 100mL of 50% ethanol–water mixture
+Let stand for 10 minutes to allow full penetration
+. Microwave Heating
+Transfer the mixture to a pressure-resistant microwave extraction container (or modified microwave oven)
+Set power: 500W
+Temperature: 60°C
+Time: 10 minutes (can be split into two 5-minute intervals with light agitation between)
+. Cooling & Filtration
+Cool the extract, filter using a Büchner funnel, retain the filtrate
+Extraction may be repeated once
+. Acidify Extract
+Adjust filtrate to pH 3 using dilute hydrochloric acid to form cocaine salt
+. Purification (Simplified Method)
+Wash the aqueous phase twice with ether or dichloromethane to remove impurities
+Adjust pH to 9–10 with 10% NaOH to precipitate the freebase
+Extract the freebase with a non-polar solvent (e.g., hexane or ether), concentrate to obtain the crude product
 = Crack cocaine synthesis =
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 ==== '''''Notes''''' ====
 You can determine the purity of the original cocaine you possessed by weighing beforehand and then weighing the freebase afterwards
+===Baking Soda Method===
+====''Materials Required''====
+. [[Cocaine]]
+. teaspoon
+. measuring cup
+. pan
+. baking soda
+====''Procedure''====
+. Pour about an 28 g of cocaine hydrochloride in the measuring cup.
+. Add a dry baking soda (sodium bicarbonate) to pH = 8 (usually about 300 mg per 1 g of cocaine hydrochloride).
+. Fill with about 3/4 cup of water. A hot distilled water (70-80°С) is preferable. About 10 ml. water for 1 g powder. If it does not dissolve well (it happens in the presence of impurities), add 1 ml of water until it is completely dissolved.
+. Pour the mixture into the pan.
+. The mixture will start to bubble. Get a knife and flatten the bubbles.
+. Continue to flatten the mixture while cooking it.
+. Continue to cook it until it is solid white.
+. Place the solid form of cocaine on paper filter for coffee machine or napkin to drain it.
+. Place crack rocks in freezer for 15-20 minutes.
+. Congratulations, you have successfully made crack cocaine.
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