25I-NBOMe: Difference between revisions

{{Warning/25I-NBOMe}}

It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] class are not [[oral]]ly active and should therefore be taken [[sublingual]]ly by simply placing the substance into one's mouth and allowing it to slowly absorb over a period of 30 minutes.

25I-NBOMe can also be vaporized and inhaled, this may cause significantly quicker effects and shorter duration as is expected from that route of administration. However, this route of administration is not recommended, unless using precise liquid measurement, due to the difficulties of measuring and handling substances active in the microgram range.

In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen fold increase in potency, allowing even the most extreme of dosages to fit in liquid form onto tabs and blotter paper, which people often mistake for [[LSD]].

This chemical had no history of human use prior to being sold online as a [[designer drug]] in 2010.

25I-NBOMe or 2C-I-NBOMe is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as [[2C-I]]. 25I-NBOMe is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R₂ and R₅ as well as an iodine attached to carbon R₄. It differs from [[2C-I]] structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. 25I-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family. This NBOMe addition contains a methoxy ether CH3-O-R bound to a benzene ring at R₂.

{{Main|Serotonergic psychedelic}}

25I-NBOMe has efficacy at the [[serotonin#The 5-HT system|5-HT_2A receptor]] where it acts as a potent [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

This compound is pharmacologically unique when compared to other psychedelics through its action on [[serotonin]] receptors. It is one of the only [[Agonist#Agonists|full agonists]] for the human [[Serotonin#The 5-HT system|5-HT_2A receptor]] receptor in existence.<ref name="pmid21174090">Ettrup, A. E. A. ; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M.; Madsen, J. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. (PubMed.gov / NCBI) | http://www.ncbi.nlm.nih.gov/pubmed/21174090</ref> In comparison, classical psychedelics such as [[LSD]], [[DMT]] and [[psilocin]] can only be considered [[Agonist#Agonists|partial agonists]].  

The [[Ki values]] of the following targets were greater than 500 Ki: [[5-HT1A]], [[D3]], [[H2]], [[5-HT1D]], [[α1A adrenergic]], [[δ opioid]], [[serotonin uptake transporter]], [[5-HT5A]], [[5-HT1B]], [[D2]], [[5-HT7]], [[D1]], [[5-HT3]], [[5-HT1E]], [[D5]], [[muscarinic M1-M5]], [[H3]], and the [[dopamine uptake transporter]].<ref name="high specific">High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand | https://www.ncbi.nlm.nih.gov/pubmed/18468904</ref>  

|+ Ki-values<ref>Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers. | https://www.ncbi.nlm.nih.gov/pubmed/21174090</ref><ref name="high specific" />

! scope="col" | Receptor || Ki (nM) || class="unsortable" | ±

! scope="row" | [[5-HT2A|5-HT_2A]]

| 0.044

! scope="row" | [[5-HT2C|5-HT_2C]]

| 2

! scope="row" | [[5-HT6|5-HT₆]]

| 73 || 12

! scope="row" | [[mu-opioid receptor|μ-opioid]]

| 82 || 14

! scope="row" | [[Histamine H1 receptor|H₁]]

| 189 || 35

! scope="row" | [[5-HT2B|5-HT_2B]]

| 231 || 73

! scope="row" | [[Κ-opioid receptor|κ-opioid]]

| 288 || 50

The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

*'''[[Effect::Sublingual numbing]]''' - Assuming the substance has been taken [[sublingual]]ly, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very obvious feeling of general numbness of the tongue and mouth which can stay for up to an hour after the blotter paper has been consumed. This is the key difference when it comes to determining whether your blotter paper contains [[LSD]] or one of the [[NBOMe]] series.

*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" itself can be described as a generally mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed.

*'''[[Effect::Perception of decreased weight]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness.

*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the tripper 25I-NBOMe is usually considered to be very energetic and stimulating. For most people, this substance induces a unique type of physical stimulation which can be described as feeling extremely energetic but in a way which does not force the tripper to move unless they genuinely choose to do so. For others however, the stimulation can be quite uncontrollable, occasionally resulting in bodily shakes and a grinding of the teeth comparable to that of [[MDMA]] and traditional stimulants such as [[amphetamine]].

*'''[[Effect::Nausea]]''' - As the tripper begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, but passes once this has either happened or the trip begins to fully set in. In comparison to other psychedelics such as [[psilocin]], [[LSD]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity.

*'''[[Effect::Language suppression]]'''

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Difficulty urinating]]'''

*'''[[Effect::Wakefulness]]'''

*'''[[Effect::Increased blood pressure]]'''

 

 

*'''[[Effect::Empathy, love and sociability enhancement]]''' - the [[entactogenic]] effects range from mild to powerful, but are inconsistently manifested. Entactogenic effects for people who try this substance usually become prominent in the presence of others. These feelings of increased sociability, love and empathy do not seem to be quite as strong or profound as those found within other [[entactogen|entactogens]] (such as [[MDMA]], [[2C-B]] and [[AMT]])

*'''[[Effect::Colour shifting]]'''

The visual geometry that is present throughout this trip is often said to be similar in appearance to that of [[LSD]]. They can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colourful in scheme, glossy in colour, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within [[2C-I]] and most of the [[2C-x]] family in general as well as completely on par with [[LSD]], [[Psilocin]] and [[DMT]] at appropriately high dosages.  

In terms of their behaviour, 25I-NBOMe’s geometry leads onto [[Effect::8A Geometry|Level 8A]] visual geometry with [[Level 8B]] remaining so far unconfirmed within this substance. They also seem to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it.

25I-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very uncommon and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]].

*'''[[Effect::Internal hallucinations]]''' - (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]''). These are more common within dark environments and can be described as lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

{|  

| [[File:Lolol.png|17px]]''Main articles: [[Research chemicals#Toxicity and harm potential|Research chemicals § Toxicity and harm potential]]'' ''&'' ''[[Responsible use #Hallucinogens|Responsible use § Hallucinogens]]''

25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The [[LD50]] has not yet been determined although it is [[Toxicity::potentially fatal at heavy dosages]].<ref name="Fatalities / Deaths"> "Fatalities / Deaths". Erowid. April 26 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref> [[PsychonautWiki]] advises that due to 25I-NBOMe's extreme potency it should not be insufflated as this method of administration appears to have led to several deaths in the past year.<ref>http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/</ref>

This substance came to media attention in early 2012 after a cluster of seven non-fatal [[overdose]]s with the drug were reported in or around Richmond, Virginia.<ref name="Kids overdosing on new drug"> "Kids overdosing on new drug. Laura Geller, WWBT NBC12, Feb 18, 2012 | http://www.nbc12.com/story/16964534/kids-overdosing-on-new-drug</ref><ref name="New street drug"> New street drug causing concern among medics. Vanessa Araiza, WBRC, Feb 28, 2012 | http://www.wsfa.com/story/16977573/new-street-drug-causing-concern-among-medics</ref> As of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.<ref name="NY Daily news"> New drug N-bomb hits the street, terrifying parents, troubling cops | http://www.nydailynews.com/news/national/new-synthetic-hallucinogen-n-bomb-killing-users-cops-article-1.1336327</ref> In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.<ref name="NY Daily news"> Breaking Bad: Digital Drug Sales, Analog Drug Deaths. Craig Malisow, Houston Press, March 13, 2013 | http://www.houstonpress.com/2013-03-14/news/motion-research-charles-carlton/</ref>

A 21-year-old man from Little Rock, Arkansas died in October 2012 after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for "several hours" beforehand. It is unclear what other drugs he may have consumed, as autopsies generally do not test for the presence of research chemicals.<ref name="21 yr old dies"> 21-year-old dies after one drop of new synthetic drug at Voodoo Fest. Naomi Martin, NOLA, November 1, 2012 | http://www.nola.com/crime/index.ssf/2012/11/21-year-old_dies_after_one_dro.html#incart_m-rpt-2/</ref>

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

Tolerance to the effects of 25I-NBOMe are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 25I-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.

==Legal issues==

*'''Australia:''' Possession, production and sale is illegal.

*'''Sweden:''' 25I-NBOMe is classed as Schedule I.<ref>Läkemedelsverkets författningssamling - http://www.lakemedelsverket.se/upload/lvfs/LVFS_2013-15.pdf</ref>

*'''UK:''' On 10 June 2014, all NBOMe's became Class A drugs which means that they’re illegal to have, give away or sell. Possession could get one up to seven years in jail and/or an unlimited fine. Supplying someone else, could result in a heavy jail time sentence, between a minimum of eight years and a life sentence and/or an unlimited fine.<ref>http://www.talktofrank.com/drug/n-bomb</ref>

*'''USA:''' On Nov 15, 2013, the DEA added 25I-NBOMe to Schedule I using their emergency scheduling powers, making it "temporarily" in Schedule I for 2 years.<ref>http://www.justice.gov/dea/divisions/hq/2013/hq111513.shtml</ref>

*'''Romania:''' In 2011, Romania banned all psychoactive substances,<ref>http://drogriporter.hu/node/2211</ref> no matter what they really are.<ref>http://www.dreptonline.ro/legislatie/legea_194_2011_comba</ref>

*'''Latvia:''' 25I-NBOMe is a Schedule I controlled substance.<ref>Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086</ref>

==Experience reports==

Anecdotal reports which describe this compound within our [[experience index]] include:

{{#ask: [[Category:25I-NBOMe]][[Category:Experience]]|format=ul|Columns=1}}

Additional experience reports can be found here:

* [https://www.erowid.org/experiences/subs/exp_25INBOMe.shtml Erowid Experience Vaults: 25I-NBOMe]

*[http://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe (Wikipedia)]

*[http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml 25I-NBOMe (Erowid)]

*[https://www.erowid.org/experiences/subs/exp_25INBOMe.shtml 25I-NBOMe experiences (Erowid)]

*[http://drugs.tripsit.me/25i-nbome 25I-NBOMe (TripSit)]

*[http://disregardeverythingisay.com/post/49302181054/25i-nbome-broken-down-and-described 25I-NBOMe (Disregard Everything I Say)]