Modafinil: Difference between revisions

Modafinil is approved by the U.S. Food and Drug Administration for the treatment of obstructive sleep apnea, shift work sleep disorder and narcolepsy.<ref>Provigal (Manufacturer's Website) | http://www.provigil.com/</ref> However, studies have shown that modafinil may also be useful off-label for alleviating the symptoms of depression,<ref>{{cite journal | vauthors=((Fava, M.)), ((Thase, M. E.)), ((DeBattista, C.)), ((Doghramji, K.)), ((Arora, S.)), ((Hughes, R. J.)) | journal=Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists | title=Modafinil augmentation of selective serotonin reuptake inhibitor therapy in MDD partial responders with persistent fatigue and sleepiness | volume=19 | issue=3 | pages=153–159 | date= September 2007 | issn=1040-1237 | doi=10.1080/10401230701464858}}</ref> bipolar disorder,<ref>{{cite journal | vauthors=((Frye, M. A.)), ((Grunze, H.)), ((Suppes, T.)), ((McElroy, S. L.)), ((Keck, P. E.)), ((Walden, J.)), ((Leverich, G. S.)), ((Altshuler, L. L.)), ((Nakelsky, S.)), ((Hwang, S.)), ((Mintz, J.)), ((Post, R. M.)) | journal=The American Journal of Psychiatry | title=A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression | volume=164 | issue=8 | pages=1242–1249 | date= August 2007 | issn=0002-953X | doi=10.1176/appi.ajp.2007.06060981}}</ref> Parkinson's disease,<ref>{{cite journal | vauthors=((Vliet, S. A. M. van)), ((Vanwersch, R. A. P.)), ((Jongsma, M. J.)), ((Gugten, J. van der)), ((Olivier, B.)), ((Philippens, I. H. C. H. M.)) | journal=Behavioural Pharmacology | title=Neuroprotective effects of modafinil in a marmoset Parkinson model: behavioral and neurochemical aspects | volume=17 | issue=5–6 | pages=453–462 | date= September 2006 | issn=0955-8810 | doi=10.1097/00008877-200609000-00011}}</ref> seasonal depressive disorder,<ref>{{cite journal | vauthors=((Lundt, L.)) | journal=Journal of Affective Disorders | title=Modafinil treatment in patients with seasonal affective disorder/winter depression: an open-label pilot study | volume=81 | issue=2 | pages=173–178 | date= August 2004 | issn=0165-0327 | doi=10.1016/S0165-0327(03)00162-9}}</ref> ADHD,<ref>{{cite journal | vauthors=((Biederman, J.)), ((Pliszka, S. R.)) | journal=The Journal of Pediatrics | title=Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents | volume=152 | issue=3 | pages=394–399 | date= March 2008 | issn=1097-6833 | doi=10.1016/j.jpeds.2007.07.052}}</ref> and various other conditions which have fatigue as a symptom.  

Modafinil has also been used as a doping agent by various athletes due to its ability to produce [[Stimulation|physical stimulation]].<ref>https://www.cyclingnews.com/news/clinger-given-two-year-suspension-for-doping</ref><ref>https://web.archive.org/web/20120122061356/http://sportsillustrated.cnn.com/2006/baseball/mlb/03/06/news.excerpt/1.html</ref><ref>https://journals.lww.com/acsm-msse/fulltext/2004/06000/effects_of_acute_modafinil_ingestion_on_exercise.23.aspx</ref> It has recently gained mainstream popularity for its use as a [[nootropic|"smart drug"]] to [[Memory enhancement|improve memory]], counteract the desire or need for sleep, and increase general productivity.<ref>https://pubmed.ncbi.nlm.nih.gov/34632515</ref>

*'''Australia:''' Modafinil is listed as a Schedule 4 (prescription only) drug in Australia and it can be prescribed for sleep apnea and narcolepsy.<ref>{{Citation | title=Modafinil | url=https://en.wikipedia.org/w/index.php?title=Modafinil&oldid=1100020692}}</ref>

*'''Austria:''' Modafinil is classed as NR (prescription only, repeated dispense prohibited) <ref>Rezeptverordnung | https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10010358</ref>