Safer injection guide: Difference between revisions

>David Hedlund
single-use spoons for preparation of drugs for injection complement syringes and hypodermic needles in preventing transmission
>David Hedlund
 
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{{Danger/Injection}}
{{Danger/Injection}}
{{#ev:youtube|https://www.youtube.com/watch?v=MppHWdZ-S_I|340x240|right|Individually color-coded [[#Single-use spoons|single-use spoons]] for preparation of drugs for injection complement [[#Syringes|syringes]] and [[#Hypodermic needles|hypodermic needles]] in preventing transmission of blood-borne diseases, which often goes unnoticed through communal spoons. ''Boiling, burning, or using common cleaning fluids, alcohol, or peroxide can reduce the amount of the hepatitis C virus (HCV), but this may not prevent you from getting infected.''<ref>https://www.cdc.gov/hepatitis/hcv/pdfs/factsheet-pwid.pdf</ref> The [[Sharing_injection_materials#Hepatitis_C|hepatitis C]] virus can survive outside the body for <span style="color:red">'''6 weeks'''</span>.<ref name="pmid24273176" /> The international prevalence of {{nowrap|hepatitis C}} is between <span style="color:red">'''60% and 80%'''</span> among people who use injection drugs.<ref name=Lancet2011>{{cite journal | vauthors = Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, Degenhardt L | title = Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews | journal = Lancet | volume = 378 | issue = 9791 | pages = 571–83 | date = August 2011 | pmid = 21802134 | pmc = 3285467 | doi = 10.1016/S0140-6736(11)61097-0 }}</ref><ref name=China2008>{{cite journal | vauthors = Xia X, Luo J, Bai J, Yu R | title = Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis | journal = Public Health | volume = 122 | issue = 10 | pages = 990–1003 | date = October 2008 | pmid = 18486955 | doi = 10.1016/j.puhe.2008.01.014 }}</ref>|frame}}
{{#ev:youtube|https://www.youtube.com/watch?v=MppHWdZ-S_I|340x240|right|[[#Sterile single-use spoon|Sterile single-use spoons]] for preparation of drugs for injection complement [[#Sterile syringe and sterile hypodermic needle|sterile syringes and sterile hypodermic needles]] in preventing transmission of blood-borne diseases, which often goes unnoticed through communal pools: ''Boiling, burning, or using common cleaning fluids, alcohol, or peroxide can reduce the amount of the hepatitis C virus (HCV), but this may not prevent you from getting infected.''<ref>https://www.cdc.gov/hepatitis/hcv/pdfs/factsheet-pwid.pdf</ref> The [[Sharing_injection_materials#Hepatitis_C|hepatitis C]] virus can survive outside the body for <span style="color:red">'''6 weeks'''</span>.<ref name="pmid24273176" /> The international prevalence of {{nowrap|hepatitis C}} is between <span style="color:red">'''60% and 80%'''</span> among people who use injection drugs.<ref name=Lancet2011>{{cite journal | vauthors = Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, Degenhardt L | title = Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews | journal = Lancet | volume = 378 | issue = 9791 | pages = 571–83 | date = August 2011 | pmid = 21802134 | pmc = 3285467 | doi = 10.1016/S0140-6736(11)61097-0 }}</ref><ref name=China2008>{{cite journal | vauthors = Xia X, Luo J, Bai J, Yu R | title = Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis | journal = Public Health | volume = 122 | issue = 10 | pages = 990–1003 | date = October 2008 | pmid = 18486955 | doi = 10.1016/j.puhe.2008.01.014 }}</ref> Hepatitis C cannot be prevented once the virus has already been introduced into the body, and currently, there is no vaccine.|frame}}


'''Injection''' is the act of delivering a [[psychoactive substance]] into the body using a hypodermic needle. Injected substances are mixed with a liquid (such as water for injection) to form a solution, which is usually either injected directly into the bloodstream via the veins (i.e. intravenous or [[#IV_injection|IV injection]]) or into the muscle tissue (i.e. intramuscular or [[#IM_injection|IM injection]]).
'''Injection''' is the act of delivering a [[psychoactive substance]] into the body using a hypodermic needle. Injected substances are mixed with a liquid (such as [[#Sterilie water for injection|sterilie water for injection]]) to form a solution, which is usually either injected directly into the bloodstream via the veins (i.e. intravenous or [[#IV_injection|IV injection]]) or into the muscle tissue (i.e. intramuscular or [[#IM_injection|IM injection]]).


Injecting substances removes any bodily filtering mechanism and IV injection results in 100% bioavailability of a substance.<ref>{{Citation | vauthors=Editor | year=2011 | title=Bioavailability of Drugs | url=http://howmed.net/pharmacology/bioavailability-of-drugs/}}</ref> Any impurities present in the product will pose a significantly greater health threat. Even medical grade substances specifically manufactured for injection carry a risk of infection and death. As a result, this guide has been deliberately named the "safe(r) injection guide" to emphasize the fact that there is no such thing as truly safe injection.
Injecting substances removes any bodily filtering mechanism and IV injection results in 100% bioavailability of a substance.<ref>{{Citation | vauthors=Editor | year=2011 | title=Bioavailability of Drugs | url=http://howmed.net/pharmacology/bioavailability-of-drugs/}}</ref> Any impurities present in the product will pose a significantly greater health threat. Even medical grade substances specifically manufactured for injection carry a risk of infection and death. As a result, this guide has been deliberately named the "safe(r) injection guide" to emphasize the fact that there is no such thing as truly safe injection.


While most psychoactive substances are capable of being injected, the practice is most commonly associated with [[opiates]] like [[heroin]], [[stimulants]] like [[methamphetamine]] and [[cocaine]], and [[dissociatives]].
While most psychoactive substances are capable of being injected, the practice is most commonly associated with [[opiates]] like [[heroin]], [[stimulants]] like [[methamphetamine]] and [[cocaine]], and [[dissociatives]].
When using opiates it is highly recommended to have [[naloxone]] nasal spray, available for free at some pharmacies, in order to reverse the effects of the opiate, and then call or get someone to call emergency services, as multiple doses of the naloxone are needed in order to continue effects, which first responders and the hospital will have. This can save a life.


==Risks and hazards==
==Risks and hazards==
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*''' Reusing hypodermic needles ''' - Reusing needles (including '''stainless steel hypodermic needles''' that can be autoclaved) is not advised for a number of medical reasons. If upon injection the needle does not hit a vein or muscle tissue, only retry with that same needle one more time if needed. It is always best to use fresh needles for each injection because needles are designed to penetrate the surface of the skin only once. After the first use, the needle becomes dulled and each additional time increases the dullness. Reusing the same needle can lead to greater risk of bodily injury and abscessed infections. Fresh needles can be found at [[needle exchange programs]] in certain areas. Needles that have been re-used many times will get macro trauma to the needle tip, resulting in a hook shape. If the needle gets hooked when injected it will cause tissue damage (e.g. a collapsed vein when taken intravenously) when it is pulled out.
*''' Reusing hypodermic needles ''' - Reusing needles (including '''stainless steel hypodermic needles''' that can be autoclaved) is not advised for a number of medical reasons. If upon injection the needle does not hit a vein or muscle tissue, only retry with that same needle one more time if needed. It is always best to use fresh needles for each injection because needles are designed to penetrate the surface of the skin only once. After the first use, the needle becomes dulled and each additional time increases the dullness. Reusing the same needle can lead to greater risk of bodily injury and abscessed infections. Fresh needles can be found at [[needle exchange programs]] in certain areas. Needles that have been re-used many times will get macro trauma to the needle tip, resulting in a hook shape. If the needle gets hooked when injected it will cause tissue damage (e.g. a collapsed vein when taken intravenously) when it is pulled out.
* '''Substances that are dangerous to inject:'''
** Some drugs '''cannot''' be taken intravenously. For example, [[hydroxyzine]] injection solutions for intravenous use is not available because they pose a risk of causing hemolysis.<ref>https://go.drugbank.com/drugs/DB00557</ref><!-- Added to: Routes of administration, Safer injection guide -->
** Other drugs are conditionally intramusculary self-injected to prevent intravenous complications that can be prevented in a hospital setting. For example, [[ketamine]] taken intravenously quicker than 1.5 minute can cause breathing depression for short time (up to a minute).<ref>Ketamine: Dreams and Realities, p276</ref>
** Talc from crushed tablets
*** '''[https://en.wikipedia.org/wiki/Emphysema Emphysema]''' - Emphysema, or pulmonary emphysema, is a lower respiratory tract disease. The intravenous use of [[methylphenidate]], commonly marketed as Ritalin and widely used as a stimulant drug in the treatment of attention deficit hyperactivity disorder, can lead to emphysematous changes known as [https://en.wikipedia.org/wiki/Emphysema#Ritalin_lung Ritalin lung].
*** '''[https://en.wikipedia.org/wiki/Pulmonary_talcosis Pulmonary talcosis]''' - Pulmonary talcosis is a pulmonary disorder caused by talc. The injection of talc from crushed pills has been associated with pulmonary talcosis in intravenous drug users.<ref name="pmid6655726">{{Cite journal|last1=Davis|first1=LL.|date=Dec 1983|title=Pulmonary "mainline" granulomatosis: talcosis secondary to intravenous heroin abuse with characteristic x-ray findings of asbestosis.|journal=J Natl Med Assoc|volume=75|issue=12|pages=1225–8|pmc=2561715|pmid=6655726}}</ref>
*'''Increased risk of [[Drug overdose|overdose]]''' - This risk is especially present with [[opiates]] such as [[heroin]]. If one is injecting opiates, it is important to have [[naloxone]] available, if possible, as this can reverse the effects of an opiate [[drug overdose]] if administered quickly.<ref>Overdose Prevention For Injection Drug Users (drugpolicy.org) | http://www.drugpolicy.org/resource/overdose-prevention-injection-drug-users</ref> The risk of fatal overdoses rise sharply after a period of cessation and [[relapse]], largely because of reduced tolerance.<ref>Why Heroin Relapse Often Ends In Death - Lauren F Friedman (Business Insider) | http://www.businessinsider.com.au/philip-seymour-hoffman-overdose-2014-2</ref> To account for this lack of tolerance, it is safer to only dose a small fraction of one's usual [[dosage]] if relapsing after an extended break. It has also been found that the environment one is in can play a role fatal overdosing. In one scientific study, rats were significantly more likely to die after receiving their dose in an environment not associated with the drug in contrast to a familiar environment.<ref>{{cite journal | vauthors=((Siegel, S.)), ((Hinson, R. E.)), ((Krank, M. D.)), ((McCully, J.)) | journal=Science | title=Heroin “Overdose” Death: Contribution of Drug-Associated Environmental Cues | volume=216 | issue=4544 | pages=436–437 | date=23 April 1982 | url=https://www.science.org/doi/10.1126/science.7200260 | issn=0036-8075 | doi=10.1126/science.7200260}}</ref>


*'''Increased risk of infection ''' - The simple act of penetrating the skin with anything is a way to introduce bacteria and viruses directly into the body. One should be as sterile as humanly possible when injecting, making sure to use alcohol swabs to wipe the injection area before and after injection. There is also the risk of infection if the injected substance is impure, adulterated, or unfiltered, which is extremely common. These substances do not pass any membrane for filtration, and ''any'' impurity in the substance will therefore be directly introduced into the body.<ref>{{cite journal | vauthors=((Evans, S. M.)), ((Cone, E. J.)), ((Henningfield, J. E.)) | journal=Journal of Pharmacology and Experimental Therapeutics | title=Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects. | volume=279 | issue=3 | pages=1345–1356 | date=1 December 1996 | url=https://jpet.aspetjournals.org/content/279/3/1345 | issn=0022-3565}}</ref> People who inject are at an increased risk of bacterial infections such as MRSA.<ref name="NHS-What-Should-I-Do">{{Citation | year=2018 | title=What should I do if I injure myself with a used needle? | url=https://www.nhs.uk/common-health-questions/accidents-first-aid-and-treatments/what-should-i-do-if-i-injure-myself-with-a-used-needle/}}</ref>
*'''Increased risk of infection ''' - The simple act of penetrating the skin with anything is a way to introduce bacteria and viruses directly into the body. One should be as sterile as humanly possible when injecting, making sure to use alcohol swabs to wipe the injection area before and after injection. There is also the risk of infection if the injected substance is impure, adulterated, or unfiltered, which is extremely common. These substances do not pass any membrane for filtration, and ''any'' impurity in the substance will therefore be directly introduced into the body.<ref>{{cite journal | vauthors=((Evans, S. M.)), ((Cone, E. J.)), ((Henningfield, J. E.)) | journal=Journal of Pharmacology and Experimental Therapeutics | title=Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects. | volume=279 | issue=3 | pages=1345–1356 | date=1 December 1996 | url=https://jpet.aspetjournals.org/content/279/3/1345 | issn=0022-3565}}</ref> People who inject are at an increased risk of bacterial infections such as MRSA.<ref name="NHS-What-Should-I-Do">{{Citation | year=2018 | title=What should I do if I injure myself with a used needle? | url=https://www.nhs.uk/common-health-questions/accidents-first-aid-and-treatments/what-should-i-do-if-i-injure-myself-with-a-used-needle/}}</ref>
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*'''Stroke risk''' - Injecting into an artery and not a vein can be a potential cause of strokes and blood embolisms. This risk is especially present with IV drug use, when one misses a vein and injects into the artery instead. This is why it is important to make sure '''one is in a vein before IV injection'''. This risk increases with the use of uncommon injection sites such as the neck: the chemicals being injected might enter an artery and go straight to the brain, causing neurological problems and strokes.<ref name="3-Potentially-Deadly-Spots">{{Citation | year=2015 | title=IV Injection Sites - Potentially Deadly Spots to Shoot Up | url=https://drugabuse.com/blog/iv-drug-abuse-3-potentially-deadly-spots-to-shoot-up/}}</ref>
*'''Stroke risk''' - Injecting into an artery and not a vein can be a potential cause of strokes and blood embolisms. This risk is especially present with IV drug use, when one misses a vein and injects into the artery instead. This is why it is important to make sure '''one is in a vein before IV injection'''. This risk increases with the use of uncommon injection sites such as the neck: the chemicals being injected might enter an artery and go straight to the brain, causing neurological problems and strokes.<ref name="3-Potentially-Deadly-Spots">{{Citation | year=2015 | title=IV Injection Sites - Potentially Deadly Spots to Shoot Up | url=https://drugabuse.com/blog/iv-drug-abuse-3-potentially-deadly-spots-to-shoot-up/}}</ref>


*'''Nerve damage''' - Injecting into the muscle tissue during an IM injection, missing a vein during IV injection, and SC injecting can all present the risk of nerve damage. The needle may puncture a nerve and cause serious, painful, and possibly fatal bodily harm. This risk is especially present if injecting into the groin, as the femoral nerve located there controls leg and muscle movement - '''damaging this nerve can result in serious problems with mobility or even paralysis.'''<ref name="3-Potentially-Deadly-Spots"/>
*'''Nerve damage''' - Injecting into the muscle tissue during an IM injection, missing a vein during IV injection, and SC injecting can all present the risk of nerve damage. The hypodermic needle may puncture a nerve and cause serious, painful, and possibly fatal bodily harm. This risk is especially present if injecting into the groin, as the femoral nerve located there controls leg and muscle movement - '''damaging this nerve can result in serious problems with mobility or even paralysis.'''<ref name="3-Potentially-Deadly-Spots"/>


*'''Deep Vein Thrombosis (DVT)''' - Deep vein thrombosis is a blood clot occurring in the deep arms of the legs and extremities, especially the legs.<ref>{{Citation | title=Deep Vein Thrombosis (DVT) Symptoms, Treatment, Causes, Diagnosis | url=https://www.medicinenet.com/deep_vein_thrombosis/article.htm}}</ref> This is a risk that is especially present with IV drug use into the groin are and the deep veins in the arm. Signs of deep vein thrombosis include; pain, swelling, redness, or tenderness of the leg or arm around the injection site. IV drug use leads to a higher rate of DVT in younger patients, with most DVT issues occurring in the groin area and the thigh.<ref>{{cite journal | vauthors=((Cornford, C. S.)), ((Mason, J. M.)), ((Inns, F.)) | journal=The British Journal of General Practice | title=Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors | volume=61 | issue=593 | pages=e781–e786 | date= December 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223775/ | issn=0960-1643 | doi=10.3399/bjgp11X613115}}</ref>
*'''Deep Vein Thrombosis (DVT)''' - Deep vein thrombosis is a blood clot occurring in the deep arms of the legs and extremities, especially the legs.<ref>{{Citation | title=Deep Vein Thrombosis (DVT) Symptoms, Treatment, Causes, Diagnosis | url=https://www.medicinenet.com/deep_vein_thrombosis/article.htm}}</ref> This is a risk that is especially present with IV drug use into the groin are and the deep veins in the arm. Signs of deep vein thrombosis include; pain, swelling, redness, or tenderness of the leg or arm around the injection site. IV drug use leads to a higher rate of DVT in younger patients, with most DVT issues occurring in the groin area and the thigh.<ref>{{cite journal | vauthors=((Cornford, C. S.)), ((Mason, J. M.)), ((Inns, F.)) | journal=The British Journal of General Practice | title=Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors | volume=61 | issue=593 | pages=e781–e786 | date= December 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223775/ | issn=0960-1643 | doi=10.3399/bjgp11X613115}}</ref>
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*'''[https://en.wikipedia.org/wiki/Extravasation_(intravenous) Extravasation]''' - Extravasation is the leakage of intravenously (IV) infused, and potentially damaging, medications into the extravascular tissue around the site of infusion. Extravasation of medication during intravenous therapy is an adverse event related to therapy that can potentially cause serious injury and permanent harm, such as tissue necrosis.
*'''[https://en.wikipedia.org/wiki/Extravasation_(intravenous) Extravasation]''' - Extravasation is the leakage of intravenously (IV) infused, and potentially damaging, medications into the extravascular tissue around the site of infusion. Extravasation of medication during intravenous therapy is an adverse event related to therapy that can potentially cause serious injury and permanent harm, such as tissue necrosis.


*'''Injecting into the wrong tissue''' - Some substances need to be injected into certain types of tissue in order to be effective. For example, [[heroin]] is most potent when IV'd and can be extremely harmful when injected into the subcutaneous tissue. [[Ketamine]], however, is typically IM'd. It is vital to ensure that one's needle is correctly inserted into the vein before proceeding with an I.V injection.
*'''Injecting into the wrong tissue''' - Some substances need to be injected into certain types of tissue in order to be effective. For example, [[heroin]] is most potent when IV'd and can be extremely harmful when injected into the subcutaneous tissue. [[Ketamine]], however, is typically IM'd. It is vital to ensure that one's hypodermic needle is correctly inserted into the vein before proceeding with an I.V injection.
 
===Substances that are dangerous to inject===
* '''Substances''': See [[List of psychoactive substances to avoid#Contraindicated substances for injection]]
*'''Increased risk of [[Drug overdose|overdose]]''' - This risk is especially present with [[opiates]] such as [[heroin]]. If one is injecting opiates, it is important to have [[naloxone]] available, if possible, as this can reverse the effects of an opiate [[drug overdose]] if administered quickly.<ref>Overdose Prevention For Injection Drug Users (drugpolicy.org) | http://www.drugpolicy.org/resource/overdose-prevention-injection-drug-users</ref> The risk of fatal overdoses rise sharply after a period of cessation and relapse, largely because of reduced tolerance.<ref>Why Heroin Relapse Often Ends In Death - Lauren F Friedman (Business Insider) | http://www.businessinsider.com.au/philip-seymour-hoffman-overdose-2014-2</ref> To account for this lack of tolerance, it is safer to only dose a small fraction of one's usual [[dosage]] if relapsing after an extended break. It has also been found that the environment one is in can play a role fatal overdosing. In one scientific study, rats were significantly more likely to die after receiving their dose in an environment not associated with the drug in contrast to a familiar environment.<ref>{{cite journal | vauthors=((Siegel, S.)), ((Hinson, R. E.)), ((Krank, M. D.)), ((McCully, J.)) | journal=Science | title=Heroin “Overdose” Death: Contribution of Drug-Associated Environmental Cues | volume=216 | issue=4544 | pages=436–437 | date=23 April 1982 | url=https://www.science.org/doi/10.1126/science.7200260 | issn=0036-8075 | doi=10.1126/science.7200260}}</ref> Other drugs are conditionally intramuscularly self-injected to prevent intravenous complications that can be prevented in a hospital setting. For example, [[ketamine]] taken intravenously quicker than 1.5 minute can cause breathing depression for short time (up to a minute).<ref>Ketamine: Dreams and Realities, p276</ref>
 
====Dosage forms not intended for injection====
See [[List of psychoactive substances to avoid#Dosage forms]]


===Virus survival time outside the body===
===Virus survival time outside the body===
Survival time for dried viruses:
Survival time for dried viruses:
* [[Sharing_injection_materials#Hepatitis_B|hepatitis B]] virus (HBV): 7 days<ref>https://www.cdc.gov/hepatitis/hbv/bfaq.htm</ref>
* [[Sharing_injection_materials#Hepatitis_B|Hepatitis B]] virus (HBV): 7 days<ref>https://www.cdc.gov/hepatitis/hbv/bfaq.htm</ref>
* [[Sharing_injection_materials#Hepatitis_C|hepatitis C]] virus (HCV): <span style="color:red">'''6 weeks'''</span>.<ref name="pmid24273176">{{cite journal |last1=Paintsil |first1=E |last2=Binka |first2=M |last3=Patel |first3=A |last4=Lindenbach |first4=BD |last5=Heimer |first5=R |title=Hepatitis C virus maintains infectivity for weeks after drying on inanimate surfaces at room temperature: implications for risks of transmission. |journal=The Journal of infectious diseases |date=15 April 2014 |volume=209 |issue=8 |pages=1205-11 |doi=10.1093/infdis/jit648 |pmid=24273176 |pmc=3969546}}</ref><!-- Added to: Safer_injection_guide, Sharing_injection_materials -->
* [[Sharing_injection_materials#Hepatitis_C|Hepatitis C]] virus (HCV): <span style="color:red">'''6 weeks'''</span>.<ref name="pmid24273176">{{cite journal |last1=Paintsil |first1=E |last2=Binka |first2=M |last3=Patel |first3=A |last4=Lindenbach |first4=BD |last5=Heimer |first5=R |title=Hepatitis C virus maintains infectivity for weeks after drying on inanimate surfaces at room temperature: implications for risks of transmission. |journal=The Journal of infectious diseases |date=15 April 2014 |volume=209 |issue=8 |pages=1205-11 |doi=10.1093/infdis/jit648 |pmid=24273176 |pmc=3969546}}</ref><!-- Added to: Safer_injection_guide, Sharing_injection_materials -->
* [[Sharing_injection_materials#HIV|HIV]]: 7 days<ref name="pmid24273176" />
* [[Sharing_injection_materials#HIV|HIV]]: 7 days<ref name="pmid24273176" />


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*'''Elastic tourniquets or stockings''' - These can be used to "tie off", or make the veins more visible and accessible, during IV injection. These materials are better for skin than leather belts or other similar objects used to "tie off". Neckties, lubricated condoms, and socks can also be used. One should always use a slip knot when tying off so the tourniquet can be removed quickly if needed. The tourniquet should be removed <b>immediately</b> if there is a loss of sensation in the limbs or the limb discolors or turns blue.
*'''Elastic tourniquets or stockings''' - These can be used to "tie off", or make the veins more visible and accessible, during IV injection. These materials are better for skin than leather belts or other similar objects used to "tie off". Neckties, lubricated condoms, and socks can also be used. One should always use a slip knot when tying off so the tourniquet can be removed quickly if needed. The tourniquet should be removed <b>immediately</b> if there is a loss of sensation in the limbs or the limb discolors or turns blue.


===Single-use spoon===
===Sterile water for injection===
[[File:Sterilewater.jpg|245px|thumb|right|USP sterile water for injection. Also sold as glass or plastic [https://en.wikipedia.org/wiki/Ampoule ampoules] by harm reduction supplies sometimes offered by needle and syringe programmes.]]
 
'''Sterile [https://en.wikipedia.org/wiki/Water_for_injection water for injection]''' (sometimes abbreviated SWFI) is standardized [https://en.wikipedia.org/wiki/Ultrapure_water ultrapure water] used to create solutions that will be administered by injection. Water for injection is generally made by distillation or reverse osmosis.<ref>https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018632s051lbl.pdf</ref><ref name=Gh2004>{{cite book|last1=Ghosh|first1=Tapash K.|last2=Jasti|first2=Bhaskara R.|title=Theory and Practice of Contemporary Pharmaceutics|date=2004|publisher=CRC Press|isbn=9780203644478|page=396|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA396|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170116162803/https://books.google.ca/books?id=whiC7aSFLY8C&pg=PA396|archivedate=2017-01-16}}</ref> Water for injection can also be used for [[Nasal spray guide|nasal sprays]], and eye drops.
 
'''Pharmacopoeia specifications for water for injection'''<br />
{| class="wikitable sortable"
|-
! Properties !! European Pharmacopoeia (Ph.Eur.)<ref>{{cite book|title=European Pharmacopoeia|date=2013|publisher=Council of Europe|location=Strasbourg, France|isbn=978-92-871-7531-1|pages=3555–3558|edition=8|language=English|chapter=Water for injections}}</ref> !! United States Pharmacopeia (USP)<ref>{{cite book|title=United States Pharmacopeia and the National Formulary (USP-NF)|date=October 2014|publisher=U.S. Pharmacopeial Convention|location=Rockville, MD, USA|page=5805|edition=USP38–NF33|chapter=USP Monographs: Water for Injection}}</ref>
|-
| Conductivity || <1.3 μS/cm at 25&nbsp;°C||<1.3 μS/cm at 25&nbsp;°C
|-
| Total organic carbon (TOC) || <0.5&nbsp;mg/L || <0.5&nbsp;mg/L
|-
| Bacteria (guideline) || <10 {{abbr|CFU|colony forming units}}/100 mL || <10 {{abbr|CFU|colony forming units}}/100 mL
|-
| Endotoxin || <0.25 IU/mL || <0.25 EU/mL
|-
| Nitrates || <0.2 ppm || N/A
|-
| Aluminium || <10 ppb || N/A
|}
# If in-line conductivity exceeds values additional testing is required before a conclusion can be made. Refer to the respective pharmacopoeia for details.
# One USP Endotoxin Unit (EU) is equal to one International Unit (IU) of endotoxin
 
====Other water sources====
* Boiled tap water: It is also important to change the water at a regular interval to prevent bacteria growth within the water. Be mindful that using multiple hypodermic needles in the same water supply can easily spread illness and disease. No other liquid substance should be added to the injection, even if it is supposed to increase the solubility of the drug in the water solution. Heat can be used to aid dissolution, but fruit juice or vinegar can lead to infections. Hot tap water should always be avoided because it contains heavy metals.
* [https://en.wikipedia.org/wiki/Eye_drop Eye drops]
** Eye drops '''with medications (e.g. the deliriant tropicamide only used for ocular administration) can be deadly when injected'''.
** Syringe designed saline drops (e.g. Wallace Cameron Ultra Saline Minipod) are distributed in modern needle-exchange programmes as they can be used efficiently either by injection or ophthalmic (if the drug is potent in small doses) route of administer which is compared to intravenous use; by demonstration, the elimination of latanoprost acid from plasma is rapid (half-life 17 minutes) after either ophthalmic or intravenous administration.<ref>{{cite web|url=https://www.drugs.com/mmx/latanoprost.html|title=Latanoprost Drug Information, Professional|publisher=Drugs.com|access-date=18 September 2014}}</ref>
* Distilled water should be avoided in large amounts directly into a vein, as it can cause your blood cells to become hypotonic, possibly leading to death. Distilled water is often sold as battery water, but since it's not designed for medical use, it may lack specifications and may be unsafe to inject.
 
===Sterile single-use spoon===
"Do not put your needle into a common pool with others. This practice may be responsible for the spread of hepatitis C in people who say that they don't share needles."<ref>[Ketamine: Dreams and Realities, p269]</ref>
"Do not put your needle into a common pool with others. This practice may be responsible for the spread of hepatitis C in people who say that they don't share needles."<ref>[Ketamine: Dreams and Realities, p269]</ref>


Typically, a small aluminum single-use spoon specifically designed for the purpose of dissolving and sterilizing the substance for injection.
Typically, a small disposable aluminum single-use spoon, ideally color-coded, specifically designed for the purpose of dissolving and sterilizing the substance for injection.


===Syringe and hypodermic needle===
====Risk of shared, non-sterile reservoirs====
[[File:Rig.png|300px|thumb|right|The full injection set up is shown above. The needle is the part that penetrates the skin, the barrel is the part that contains the drug solution, the plunger is pulled to check if one is in a vein and pushed down upon injection.]]
In situations where people inject drugs, there's a chance of unknowingly sharing equipment like spoons, shot glasses, or even the concave bottom of a soda can.
This can happen for several reasons:
* '''Incomplete sterilization:''' Washing with dish soap doesn't guarantee sterility. Used equipment might be put back for reuse by others, creating a risk of bloodborne disease transmission.
* '''Memory lapses:''' People may forget that the equipment was previously used and unintentionally share it, putting themselves and others at risk.
 
===Sterile syringe and sterile hypodermic needle===
[[File:Rig.png|300px|thumb|right|The full injection set up is shown above. The hypodermic needle is the part that penetrates the skin, the barrel is the part that contains the drug solution, the plunger is pulled to check if one is in a vein and pushed down upon injection.]]


About 0.1 mL of the solution is lost in conventional syringes through the [https://en.wikipedia.org/wiki/Luer_taper Luer taper] tip and the Luer taper adapter of the hypodermic needle. That can be compensated by either adding extra 10% or 5% substance in 1 mL or 2 mL syringes respectively, or by using [https://en.wikipedia.org/wiki/Low_dead_space_syringe low dead space syringes].<!-- Added to: Routes of administration, Safer injection guide -->
About 0.1 mL of the solution is lost in conventional syringes through the [https://en.wikipedia.org/wiki/Luer_taper Luer taper] tip and the Luer taper adapter of the hypodermic needle. That can be compensated by either adding extra 10% or 5% substance in 1 mL or 2 mL syringes respectively, or by using [https://en.wikipedia.org/wiki/Low_dead_space_syringe low dead space syringes].<!-- Added to: Routes of administration, Safer injection guide -->
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Thinner hypodermic needles cause smaller wounds and scars.
Thinner hypodermic needles cause smaller wounds and scars.


====Syringe with intravenous hypodermic needle====
====Sterile syringe with sterile intravenous hypodermic needle====
Used for IV injection. Insulin syringes (with cemented needles) are common, but 1-2 mL syringes with short hypodermic needles (0.5 inch (13 mm), and 14-30 G) are also used (e.g. "tuberculin syringes"), meant to penetrate surface veins.
Used for IV injection. Insulin syringes (with cemented hypodermic needles) are common, but 1-2 mL syringes with short hypodermic needles (0.5 inch (13 mm), and 14-30 G) are also used (e.g. "tuberculin syringes"), meant to penetrate surface veins.


Drug users typically use a 25 g rapid (5-16 seconds) intravenous injection by arm via the median cubital vein to get a [https://en.wikipedia.org/wiki/Rush_(psychology) rush]. However, smaller gauges such as 30 g can be used to prevent a vein collapse for repeated administration. Hypodermic needles smaller than 30 G are normally used for subcutaneous injection, but not for intravenous (coagulated blood immediately after blood response) or intramuscular use (the finest needles are very short).
Drug users typically use a 25 g rapid (5-16 seconds) intravenous injection by arm via the median cubital vein to get a [https://en.wikipedia.org/wiki/Rush_(psychology) rush]. However, smaller gauges such as 30 g can be used to prevent a vein collapse for repeated administration. Hypodermic needles smaller than 30 G are normally used for subcutaneous injection, but not for intravenous (coagulated blood immediately after blood response) or intramuscular use (the finest hypodermic needles are very short).


====Syringe with intramuscular hypodermic needle====
====Sterile syringe with sterile intramuscular hypodermic needle====
[[File:Needle length diagram.png|300px|thumb|left|An IM needle differs from an IV needle in length.]]
[[File:Needle length diagram.png|300px|thumb|left|IM hypodermic needles are longer than IV hypodermic needles.]]


This type of syringe is used for the less common intramuscular (IM) injection. The syringes are typically 1 mL to prevent slow injection, and the hypodermic needles typically has a needle hole size of 22-25G, and are typically 1- to 1.5-inch (25–38 mm, and up to 3 inch (76 mm) for large adults) depending on body weight, which is longer than the traditional insulin needles seen for IV use because it is designed to penetrate deep into the muscular tissue instead of a vein.
This type of syringe is used for the less common intramuscular (IM) injection. The syringes are typically 1 mL to prevent slow injection, and the hypodermic needles typically has a hole size of 22-25G, and are typically 1- to 1.5-inch (25–38 mm, and up to 3 inch (76 mm) for large adults) depending on body weight, which is longer than the traditional insulin needles seen for IV use because it is designed to penetrate deep into the muscular tissue instead of a vein.


"It is common to have muscle pain when injecting larger doses of liquid Ketamine into muscle tissue. The pain can continue for several days if it is not administered properly. The muscle soreness can be somewhat controlled by using a very fine (small gauge) needle and by injecting very slowly. It should take 15-30 or more seconds to inject a dose into a muscle. If you feel it begin to sting, slow down the injection rate."<ref>{{cite web |title=Erowid Ketamine Vault : Dosage |url=http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml#im |website=www.erowid.org}}</ref>
"It is common to have muscle pain when injecting larger doses of liquid Ketamine into muscle tissue. The pain can continue for several days if it is not administered properly. The muscle soreness can be somewhat controlled by using a very fine (small gauge) needle and by injecting very slowly. It should take 15-30 or more seconds to inject a dose into a muscle. If you feel it begin to sting, slow down the injection rate."<ref>{{cite web |title=Erowid Ketamine Vault : Dosage |url=http://www.erowid.org/chemicals/ketamine/ketamine_dose.shtml#im |website=www.erowid.org}}</ref>
===Water for injection===
[[File:Sterilewater.jpg|245px|thumb|right|The USP standards for water for injection includes a "target limit response" of 500 µg of Carbon/L, and 10 [https://en.wikipedia.org/wiki/Colony-forming_unit {{abbr|CFU|colony forming units}}]/100mL.<ref>https://www.usp.org/frequently-asked-questions/water-pharmaceutical-and-analytical-purposes</ref>]]
'''[https://en.wikipedia.org/wiki/Water_for_injection Water for injection]''' is water of extra high quality without significant contamination.
Water for injection is generally made by distillation or reverse osmosis.<ref name=Gh2004>{{cite book|last1=Ghosh|first1=Tapash K.|last2=Jasti|first2=Bhaskara R.|title=Theory and Practice of Contemporary Pharmaceutics|date=2004|publisher=CRC Press|isbn=9780203644478|page=396|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA396|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170116162803/https://books.google.ca/books?id=whiC7aSFLY8C&pg=PA396|archivedate=2017-01-16}}</ref>
Syringe designed saline drops (e.g. Wallace Cameron Ultra Saline Minipod) are distributed in modern needle-exchange programmes as they can be used efficiently either by injection or ophthalmic (if the drug is potent in small doses) route of administer which is compared to intravenous use; by demonstration, the elimination of latanoprost acid from plasma is rapid (half-life 17 minutes) after either ophthalmic or intravenous administration.<ref>{{cite web|url=https://www.drugs.com/mmx/latanoprost.html|title=Latanoprost Drug Information, Professional|publisher=Drugs.com|access-date=18 September 2014}}</ref>
* [https://en.wikipedia.org/wiki/Eye_drop Eye drops] '''with medications can be deadly when injected'''. However, preservative-free eye drops made of [https://en.wikipedia.org/wiki/Saline_(medicine) saline] from sterilized water (as isotonic solution) are sometimes used for injection.
* Distilled water should be avoided in large amounts directly into a vein, as it can cause your blood cells to become hypotonic, possibly leading to death.Water for injection is generally made by [[distillation]] or [[reverse osmosis]].<ref name=Gh2004>{{cite book|last1=Ghosh|first1=Tapash K.|last2=Jasti|first2=Bhaskara R.|title=Theory and Practice of Contemporary Pharmaceutics|date=2004|publisher=CRC Press|isbn=9780203644478|page=396|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA396|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170116162803/https://books.google.ca/books?id=whiC7aSFLY8C&pg=PA396|archivedate=2017-01-16}}</ref>
* Hot tap water should always be avoided because it contains heavy metals.
* Boiled tap water: It is also important to change the water at a regular interval to prevent bacteria growth within the water. Be mindful that using multiple needles in the same water supply can easily spread illness and disease. No other liquid substance should be added to the injection, even if it is supposed to increase the solubility of the drug in the water solution. Heat can be used to aid dissolution, but fruit juice or vinegar can lead to infections.
Water for injection can also be used for [[Nasal spray guide|nasal sprays]], and eye drops.


===Naloxone===
===Naloxone===
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<span style="color:red"><b>It is extremely important to vary the administration sites of injections.</b></span> The overuse of one particular injection site can lead to degradation of the tissue of the site. With IV use, this can lead to collapsed veins.<ref>http://new.sfaf.org/tspsf/speedometer/shooters/vein_care.html</ref> Once a vein has collapsed, it cannot be used again. In regard to IM injection use, there have been animal studies that show there is risk of permanent scarring and damage the peripheral veins and muscle tissue if the site is overused.<ref>{{cite journal | vauthors=((Diness, V.)) | journal=Acta Pharmacologica Et Toxicologica | title=Local tissue damage after intramuscular injections in rabbits and pigs: quantitation by determination of creatine kinase activity at injection sites | volume=56 | issue=5 | pages=410–415 | date= May 1985 | issn=0001-6683 | doi=10.1111/j.1600-0773.1985.tb01311.x}}</ref>
<span style="color:red"><b>It is extremely important to vary the administration sites of injections.</b></span> The overuse of one particular injection site can lead to degradation of the tissue of the site. With IV use, this can lead to collapsed veins.<ref>http://new.sfaf.org/tspsf/speedometer/shooters/vein_care.html</ref> Once a vein has collapsed, it cannot be used again. In regard to IM injection use, there have been animal studies that show there is risk of permanent scarring and damage the peripheral veins and muscle tissue if the site is overused.<ref>{{cite journal | vauthors=((Diness, V.)) | journal=Acta Pharmacologica Et Toxicologica | title=Local tissue damage after intramuscular injections in rabbits and pigs: quantitation by determination of creatine kinase activity at injection sites | volume=56 | issue=5 | pages=410–415 | date= May 1985 | issn=0001-6683 | doi=10.1111/j.1600-0773.1985.tb01311.x}}</ref>


'''It is extremely important to never inject pills''' as they contain pill binders that may congregate and cause blood clots and other serious bodily harm. This risk may be mitigated by the use of micron filters and extraction of the active pill ingredient, but it is not advised to inject pills of any kind. This issue is most often seen with pills that contain [[oxycodone]]. When crushed these pills may look safe to inject, but they may harbor pill binders and other materials that can clog up the veins and cause blockages in the bloodstream, resulting in circulation issues and kidney complications.<ref>{{Citation | title=What Are The Dangers of Snorting or Injecting OxyContin? | url=https://americanaddictioncenters.org/prescription-drugs/smoking-snorting-injecting}} </ref>
====Solution for injection====
 
[[#Sterile water for injection|Sterile water for injection]] (SWFI) should be placed in a [[#Sterile single-use spoon|single-use spoon]] when substances for injection are dissolved, in order to avoid spreading blood-borne diseases.
Avoid heating up solutions of substances with poor water solubility (yohimbine, and caffeine, for example), because they will go back to their solid state once you have injected them into the body. Dilute them with more water and use larger volume syringes if needed.
 
====Water for injection====
Water for injection should be placed in a [[#Single-use spoon|single-use spoon]] when substances for injection are dissolved, in order to avoid spreading blood-borne diseases.


====IV injection====
====IV injection====
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*'''Development of peripheral veins scar tissue''' - One should always inject the substance towards the heart, not away from it. By injecting with the flow of blood you may avoid problems caused by creating scar tissue or clots which occur when injecting against the flow of blood in the veins <ref>{{Citation | vauthors=((Brunsdon, N.)) | year=2018 | title=Better Vein Care Guide | url=https://anypositivechange.org/better-vein-care/}}</ref>. If the substance flows towards against the heart, instead of away from it, it may lead to increased scar tissue and risk of infection.
*'''Development of peripheral veins scar tissue''' - One should always inject the substance towards the heart, not away from it. By injecting with the flow of blood you may avoid problems caused by creating scar tissue or clots which occur when injecting against the flow of blood in the veins <ref>{{Citation | vauthors=((Brunsdon, N.)) | year=2018 | title=Better Vein Care Guide | url=https://anypositivechange.org/better-vein-care/}}</ref>. If the substance flows towards against the heart, instead of away from it, it may lead to increased scar tissue and risk of infection.


====='''Procedure'''=====
=====Procedure=====
{{Safer injection guide-basic procedure}}
{{Safer injection guide-basic procedure}}
#If using the traditional crook of the elbow injection site, one may need to apply pressure above the vein to make the vein stick out more. This is typically achieved through "tying off," which refers to the practice of wrapping a solid band or tourniquet around the upper forearm so that blood constricts and the veins become more visible.
#If using the traditional crook of the elbow injection site, one may need to apply pressure above the vein to make the vein stick out more. This is typically achieved through "tying off," which refers to the practice of wrapping a solid band or tourniquet around the upper forearm so that blood constricts and the veins become more visible.
#Take three deep breaths.
#Take three deep breaths.
#The needle will most likely have a bevel. It is important to angle the beveled edge away from the skin, so the point of the needle penetrates the vein and injects.
#The hypodermic needle will most likely have a bevel. It is important to angle the beveled edge away from the skin, so the point of the needle penetrates the vein and injects.
#[https://en.wikipedia.org/wiki/Venipuncture Venipuncture]: However, for typical injection in the arm, penetrate the skin at a 15 to 35-degree angle and always inject toward the heart. Avoid to push the hypodermic needle deeply into the vein to avoid [https://en.wikipedia.org/wiki/Extravasation_(intravenous) extravasation] which can serious injury and permanent harm, such as tissue necrosis.
#[https://en.wikipedia.org/wiki/Venipuncture Venipuncture]: However, for typical injection in the arm, penetrate the skin at a 15 to 35-degree angle and always inject toward the heart. Avoid to push the hypodermic needle deeply into the vein to avoid [https://en.wikipedia.org/wiki/Extravasation_(intravenous) extravasation] which can serious injury and permanent harm, such as tissue necrosis.
#Once you have penetrated the skin, and it feels that you have punctured the vein with the needle: Pull back on the plunger of the syringe, or hold the syringe vertically, so the blood can flow into it. If there is blood present in the syringe, the needle has hit a vein, and it is good to inject. If there is no blood in the syringe barrel or one feels a suck back, '''the needle is not in a vein; it is in subcutaneous tissue, so do NOT inject! Repeat the former ''venipuncture'' steps until the needle hits a vein.'''
#Once you have penetrated the skin, and it feels that you have punctured the vein with the hypodermic needle: Pull back on the plunger of the syringe, or hold the syringe vertically, so the blood can flow into it. If there is blood present in the syringe, the needle has hit a vein, and it is good to inject. If there is no blood in the syringe barrel or one feels a suck back, '''the needle is not in a vein; it is in subcutaneous tissue, so do NOT inject! Repeat the former ''venipuncture'' steps until the needle hits a vein.'''
#Once the needle is in the vein, push the plunger down ''GRADUALLY'' for at least 30 seconds. It is highly advised not to rush the injection, especially if one is IVing a strong [[opiate]], such as [[heroin]]. However, leaving the needle in the vein for a long time can cause it to be irritated.
#Once the hypodermic needle is in the vein, push the plunger down ''GRADUALLY'' for at least 30 seconds. It is highly advised not to rush the injection, especially if one is IVing a strong [[opiate]], such as [[heroin]]. However, leaving the needle in the vein for a long time can cause it to be irritated.
#Once all the solutions have been injected, slowly remove the needle.
#Once all the solutions have been injected, slowly remove the hypodermic needle.
#Block the bleeding from the vein by gently pushing a piece of toilet paper on it for approximately 20 seconds.
#Block the bleeding from the vein by gently pushing a piece of toilet paper on it for approximately 20 seconds.
#Use a new alcohol swab to clean the injection site. There may be a little blood.
#Use a new alcohol swab to clean the injection site. There may be a little blood.


======'''Foot injection'''======
======Foot injection======
For self-administration it is often easier, especially for people with a high percentage of body fat, to inject a [https://en.wikipedia.org/wiki/Great_saphenous_vein great saphenous vein] in a foot rather than the [https://en.wikipedia.org/wiki/Median_cubital_vein median cubital vein] by arm. Also, wounds in the feet might look less suspicious and are easy to cover with socks. A foot bath will enlarge the veins.
For self-administration it is often easier, especially for people with a high percentage of body fat, to inject a [https://en.wikipedia.org/wiki/Great_saphenous_vein great saphenous vein] in a foot rather than the [https://en.wikipedia.org/wiki/Median_cubital_vein median cubital vein] by arm. Also, wounds in the feet might look less suspicious and are easy to cover with socks. A foot bath will enlarge the veins.


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</center>
</center>


*'''Needle length''' - It is important that one uses a needle that is longer than the IV needle in order to reach the muscle tissue.
*'''Hypodermic needle length''' - It is important that one uses a hypodermic needle that is longer than the IV needle in order to reach the muscle tissue.


{{Safer injection guide-basic procedure}}
{{Safer injection guide-basic procedure}}
#To prepare the needle, hold the syringe with the dominant hand and pull the cover off with the other hand. Place the syringe between the thumb and first finger.
#To prepare the hypodermic needle, hold the syringe with the dominant hand and pull the cover off with the other hand. Place the syringe between the thumb and first finger.
#Hold the skin around where the injection will be administered. With the free hand, gently press on and pull the skin so that it is slightly tight.
#Hold the skin around where the injection will be administered. With the free hand, gently press on and pull the skin so that it is slightly tight.
#Hold the syringe barrel tightly and use the wrist to inject the needle through the skin and into the muscle at a 90-degree angle.
#Hold the syringe barrel tightly and use the wrist to inject the hypodermic needle through the skin and into the muscle at a 90-degree angle.
#Let go of the skin with the other hand. Hold the syringe, so it stays pointed straight in. Pull back on the plunger a little to make sure the needle did not hit a blood vessel. The point of intramuscular injection is to inject within the muscle itself. '''If blood comes back into the syringe barrel, remove the needle immediately and do not inject.''' If possible, dispose of the needle and syringe and get a new one. When giving the second injection, use a different injection site than the first.
#Let go of the skin with the other hand. Hold the syringe, so it stays pointed straight in. Pull back on the plunger a little to make sure the hypodermic needle did not hit a blood vessel. The point of intramuscular injection is to inject within the muscle itself. '''If blood comes back into the syringe barrel, remove the needle immediately and do not inject.''' If possible, dispose of the needle and syringe and get a new one. When giving the second injection, use a different injection site than the first.
#Push down on the plunger to inject the solution. Do not push the plunger down hard and fast; some substance solutions may burn. Injecting at a slower rate reduces the pain.
#Push down on the plunger to inject the solution. Do not push the plunger down hard and fast; some substance solutions may burn. Injecting at a slower rate reduces the pain.
#Once the solution is injected, remove the needle at the same angle as it went in. Re-swab the area of injection with an alcohol swab.
#Once the solution is injected, remove the hypodermic needle at the same angle as it went in. Re-swab the area of injection with an alcohol swab.


====SC injection====
====SC injection====
[[File:SC injection skin pinch.jpg|300px|thumb|left|Hold and pinch the skin to inject into the subcutaneous tissue.]]
[[File:SC injection skin pinch.jpg|300px|thumb|left|Hold and pinch the skin to inject into the subcutaneous tissue.]]
'''<span style="color:red">Warning: This method of injection is uncommon and is not advised. The needle may break off in the skin, hit a nerve, or cause scarring, lumps, and other skin problems. Additionally, the risks of infection are greatly increased when using this method of administration.</span>'''
'''<span style="color:red">Warning: This method of injection is uncommon and is not advised. The hypodermic needle may break off in the skin, hit a nerve, or cause scarring, lumps, and other skin problems. Additionally, the risks of infection are greatly increased when using this method of administration.</span>'''


*'''Needle type''' - An IV or insulin needle length is suitable for this type of injection. Do not use a longer needle length as it can penetrate other types of tissue and cause medical problems.
*'''Hypodermic needle type''' - An IV or insulin hypodermic needle length is suitable for this type of injection. Do not use a longer needle length as it can penetrate other types of tissue and cause medical problems.
*'''Administration sites''' - The areas where SC injections can be administered in are the abdomen, the thigh, the lower back, and the upper arm.<ref>How To Give A Subcutaneous Injection (drugs.com) | https://www.drugs.com/cg/how-to-give-a-subcutaneous-injection.html/</ref> It is important to vary the injection site to avoid infections or injuries. Seek immediate medical care if a rash develops at the injection site or swelling is present after injecting.
*'''Administration sites''' - The areas where SC injections can be administered in are the abdomen, the thigh, the lower back, and the upper arm.<ref>How To Give A Subcutaneous Injection (drugs.com) | https://www.drugs.com/cg/how-to-give-a-subcutaneous-injection.html/</ref> It is important to vary the injection site to avoid infections or injuries. Seek immediate medical care if a rash develops at the injection site or swelling is present after injecting.


{{Safer injection guide-basic procedure}}
{{Safer injection guide-basic procedure}}
#Hold the syringe in the dominant hand and grasp and pinch the skin where one will administer the SC injection.
#Hold the syringe in the dominant hand and grasp and pinch the skin where one will administer the SC injection.
#Inject the needle into the skin and slightly pull the plunger back. No blood should enter the syringe barrel to ensure that you are in subcutaneous tissue.
#Insert the hypodermic needle into the skin and slightly pull the plunger back. No blood should enter the syringe barrel to ensure that you are in subcutaneous tissue.
#Slowly inject the substance into the subcutaneous (skin) tissue.
#Slowly inject the substance into the subcutaneous tissue.
#Remove the needle at the same angle that it entered and re-wipe the injection site with an alcohol wipe.
#Remove the hypodermic needle at the same angle that it entered and re-wipe the injection site with an alcohol wipe.


==Cleaning up after injection==
==Cleaning up after injection==
In order to prevent the spread of blood-borne diseases and bacterial infections, <span style="color:red"><b>clean up and dispose of used needles and syringe barrels properly</b></span>. The needle and barrel of the syringe can hold old blood, that can harbor viruses.
In order to prevent the spread of blood-borne diseases and bacterial infections, <span style="color:red"><b>clean up and dispose of used hypodermic needles and syringe barrels properly</b></span>. The needle and barrel of the syringe can hold old blood, that can harbor viruses.


===Single-use spoons===
===Single-use spoons===
Single-use spoons are made of thin metal sheets, so they are easy to press together to indicate that they have been used.
Single-use spoons are made of thin metal sheets, which make them easy to press together to indicate that they have been used.


===Hypodermic needles===
===Hypodermic needles===
One should always re-cap their '''own''' old needle after injection to ensure that other people are not exposed to the old blood that still resides in the needle. The needle can and will cause accidental skin pricks that transmit disease. '''Do not let others re-cap someone's own used needle!'''
One should always re-cap their '''own''' old hypodermic needle after injection to ensure that other people are not exposed to the old blood that still resides in the needle. The needle can and will cause accidental skin pricks that transmit disease. '''Do not let others re-cap someone's own used needle!'''


After the needle has been re-capped, it should be disposed of properly. Take the used needle and syringe to a medical waste/sharps disposal facility near you. Do not simply leave the needles lying around as this makes them available for re-use by others and is a possible vector for disease. Leaving needles lying around, especially if they are uncapped, also leads to an increased risk of accidental skin pricking which can cause injury, infection, or disease.
After the needle has been re-capped, it should be disposed of properly. Take the used needle and syringe to a medical waste/sharps disposal facility near you. Do not simply leave the needles lying around as this makes them available for re-use by others and is a possible vector for disease. Leaving needles lying around, especially if they are uncapped, also leads to an increased risk of accidental skin pricking which can cause injury, infection, or disease.
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You'll find sharps disposal containers in your local drug store, often offered gratis. They are also offered in needle exchange programs.
You'll find sharps disposal containers in your local drug store, often offered gratis. They are also offered in needle exchange programs.


However, if you don't have access to a sharps disposal container, please collect the syringes and needles in a puncture and leak-resistant plastic container, and leave it to your drug store as soon as possible.  
However, if you don't have access to a sharps disposal container, please collect the syringes and hypodermic needles in a puncture and leak-resistant plastic container, and leave it to your drug store as soon as possible.  


===Biological residues===
===Biological residues===
Don't flush residues from a syringe in a glass of water and leave publicity available, someone might drink from it.
Don't flush residues from the hypodermic needle and syringe in a glass of water and leave publicity available. Blood residues can fool someone to think it's actually squash and drink from it (yes, for real). Also, glass or other containers, contaminated with blood, can cause blood-borne diseases when used by others. It's safer to flush the syringe and needle under an interior water tap in the sink, as long as they don't get in touch with it.


==Aftercare==
==Aftercare==
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Sterilizing capacity of an autoclave:
Sterilizing capacity of an autoclave:
* [[Sharing_injection_materials#Hepatitis_C|Hepatisis C virus]] (HCV): Sterilizing needles using bleach, boiling water or alcohol may not kill HCV.<ref>{{cite journal |last1=Mukherjee |first1=TI |last2=Pillai |first2=V |last3=Ali |first3=SH |last4=Altice |first4=FL |last5=Kamarulzaman |first5=A |last6=Wickersham |first6=JA |doi=10.1016/j.drugpo.2017.05.041 |pmid=28652072 |pmc=5592150}}</ref> So it is not advised to share cooking pans to sterilizing equipment.
* [[Sharing_injection_materials#Hepatitis_C|Hepatisis C virus]] (HCV): Sterilizing hypodermic needles using bleach, boiling water or alcohol may not kill HCV.<ref>{{cite journal |last1=Mukherjee |first1=TI |last2=Pillai |first2=V |last3=Ali |first3=SH |last4=Altice |first4=FL |last5=Kamarulzaman |first5=A |last6=Wickersham |first6=JA |doi=10.1016/j.drugpo.2017.05.041 |pmid=28652072 |pmc=5592150}}</ref> So it is not advised to share cooking pans to sterilizing equipment.


Sterilizing capacity of an autoclave or pressure cooker:
Sterilizing capacity of an autoclave or pressure cooker:
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The injection of illegal drugs may lead to a higher risk of legal consequences. These consequences differ by country, state, and county. One should research the laws in their region before choosing to inject.  
The injection of illegal drugs may lead to a higher risk of legal consequences. These consequences differ by country, state, and county. One should research the laws in their region before choosing to inject.  


*'''Needles and syringes''' - Needles and syringes are illegal to possess without a prescription in some states,<ref>{{Citation | title=Syringe Distribution Laws | url=https://lawatlas.org/datasets/syringe-policies-laws-regulating-non-retail-distribution-of-drug-parapherna}}</ref> and countries.
*'''[https://en.wikipedia.org/wiki/Hypodermic_needle Hypodermic needles] and syringes''' - Hypodermic needles and syringes are illegal to possess without a prescription in some states,<ref>{{Citation | title=Syringe Distribution Laws | url=https://lawatlas.org/datasets/syringe-policies-laws-regulating-non-retail-distribution-of-drug-parapherna}}</ref> and countries.


*'''Overdoses''' - If someone overdoses, the person who stays with them and calls emergency medical services will not be prosecuted. Do not simply leave a person who has overdosed to die out of fear of legal repercussions. The legal repercussions of staying with someone that has experienced [[drug overdose]] and calling emergency medical services vary by location.
*'''Overdoses''' - If someone overdoses, the person who stays with them and calls emergency medical services will not be prosecuted. Do not simply leave a person who has overdosed to die out of fear of legal repercussions. The legal repercussions of staying with someone that has experienced [[drug overdose]] and calling emergency medical services vary by location.
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**'''United States''': At a federal level in the USA, naloxone is a prescription drug. Many states have programs that make naloxone over the counter and available at request at most pharmacies. In the United States, most jurisdictions have programs to deploy naloxone to law enforcement and fire and rescue services. The states that have a [[naloxone]] access laws (in varying degrees) as of January 2016 are: Alabama, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Kentucky, Louisiana, Maryland, Massachusetts, Minnesota, Michigan, Mississippi, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington State, West Virginia, and Wisconsin.<ref>State Naloxone Laws in the USA http://www.drugpolicy.org/sites/default/files/Fact%20Sheet_State%20based%20Overdose%20Prevention%20Legislation%20%28January%202016%29.pdf</ref>
**'''United States''': At a federal level in the USA, naloxone is a prescription drug. Many states have programs that make naloxone over the counter and available at request at most pharmacies. In the United States, most jurisdictions have programs to deploy naloxone to law enforcement and fire and rescue services. The states that have a [[naloxone]] access laws (in varying degrees) as of January 2016 are: Alabama, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Kentucky, Louisiana, Maryland, Massachusetts, Minnesota, Michigan, Mississippi, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington State, West Virginia, and Wisconsin.<ref>State Naloxone Laws in the USA http://www.drugpolicy.org/sites/default/files/Fact%20Sheet_State%20based%20Overdose%20Prevention%20Legislation%20%28January%202016%29.pdf</ref>
**'''United Kingdom''': In the United Kingdom, naloxone is considered a Prescription Only Medicine. It is also given out at drug intervention programs and needle distribution centers, provided one has undertaken a quick 10 minute training protocol.
**'''United Kingdom''': In the United Kingdom, naloxone is considered a Prescription Only Medicine. It is also given out at drug intervention programs and needle distribution centers, provided one has undertaken a quick 10 minute training protocol.
==Substance notes==
===Drugs that are useless to inject===
* [[Lisdexamfetamine dimesylate]] (Vyvanse) -  is formulated with a low potential for abuse as it is a prodrug necessitating conversion to dextroamphetamine in the gastrointestinal tract or liver.
===Drugs that require special consideration to inject===
* Some psychoactive substances such as [[benzodiazepines]] (valium, oxazepam, clonazepam) are water soluble to a small degree (about 3.5ml/mg).


==See also==  
==See also==  
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[[Category:Responsible drug use]]
[[Category:Responsible drug use]]
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