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4-AcO-MET: Difference between revisions

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{{SubstanceBox/4-AcO-MET}}
{{SubstanceBox/4-AcO-MET}}


'''4-Acetoxy-N-ethyl-N-methyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''' and '''Azomet''') is a novel synthetic [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] chemical class that produces [[psilocybin mushroom]]-like [[psychedelic]] effects when [[routes of administration|administered]]. 4-AcO-MET possesses a molecular structure and pharmacological effect profile that resemble that of the [[psilocin]]-like tryptamine [[4-HO-MET]] ('''Metocin''') which it is thought to act as a [[prodrug]] for.  
'''4-Acetoxy-N-methyl-N-ethyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].  


Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is commonly sold as a [[research chemical]] through the use of online vendors. 4-AcO-MET is also occasionally found in pressed pills such as blue diamonds, which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet". This is most likely due to 4-AcO-MET being one of the only few research chemicals that are legal in this country and easily purchasable on research chemical markets.{{citation needed}}
The substance is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a [[research chemical]] online. It is highly advised to use [[harm reduction practices]] if using this substance.


==Chemistry==
==Chemistry==
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==Pharmacology==
==Pharmacology==
{{Further|Serotonergic psychedelic}}
{{Further|Serotonergic psychedelic}}
It has been suggested that the substance is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.{{citation needed}}
4-AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
4-AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.


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==Subjective effects==
==Subjective effects==
{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
*'''[[Effect::Excessive yawning]]''' - This component has been observed to occur on most serotonergic psychedelics, but seems especially liable to occur on 4-substituted tryptamines.
|{{effects/physical|
*'''[[Effect::Sedation]]''' - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation. However, the sedation is often considered to be less strong than that of the related compounds [[psilocin]] and [[4-AcO-DMT]].
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
*'''[[Effect::Sedation]]''' - Regarding its effects on the physical energy levels of the tripper, 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation.
*'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension.
*'''[[Effect::Muscle contractions]]''' - The muscle contractions that can occur by 4-AcO-MET tend to be transient and benign feeling in nature, compared to many other [[tryptamines]], [[phenethylamines]] and [[lysergamides]].
*'''[[Effect::Muscle relaxation]]'''
*'''[[Effect::Excessive yawning]]''' - This effect seems to be uniquely pronounced among psilocin and related tryptamines. It can occur to a lesser degree on [[LSD]] and very rarely on psychedelic [[phenethylamines]] like [[mescaline]]. It typically occurs in conjunction with [[watery eyes]].
*'''[[Effect::Watery eyes]]'''
*'''[[Effect::Olfactory hallucination]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Runny nose]]'''
*'''[[Effect::Increased salivation]]'''
*'''[[Effect::Teeth grinding]]''' - This component is considerably less intense when compared with substances like [[MDMA]] when it occurs.
*'''[[Effect::Nausea]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Pupil dilation]]'''


===Cognitive effects===
}}
{{effects/visual|
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''
 
====Distortions====
*'''[[Effect::Visual drifting|Drifting]]''' ''([[Visual drifting#Melting|melting]], [[Visual drifting#Flowing|flowing]], [[Visual drifting#Breathing|breathing]] and [[Visual drifting#morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, cartooon-like in style, slow and smooth in motion and static in appearance.
*'''[[Effect::After images]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::Environmental patterning]]'''
*'''[[Effect::Scenery slicing]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Tracers]]'''
 
====[[Effect::Geometry]]====
The visual geometry presented by 4-AcO-MET is similar in appearance to that of [[psilocin]], [[4-AcO-DMT]] and [[4-HO-MiPT]] but with stronger "synthetic" digital undertones comparable to [[2C-B]]. 4-AcO-MET can be comprehensively described through its [[Geometry#Variations|variations]] as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "synthetic" and "natural" feel to them which is reminiscent of both [[LSD]] and [[psilocybin]] respectively. Higher dosages are significantly more likely to result in states of [[Effect::8A Geometry|level 8A]] visual geometry over [[8B Geometry|level 8B]].
 
====Hallucinatory states====
4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used [[psychedelic]]s. These effects generally include:
 
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'') - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[Effect::geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
 
}}
 
|{{effects/cognitive|
The cognitive effects of 4-AcO-MET are described by much as somewhat relaxing, yet fast-paced in style with similarities to [[psychedelic]]s such as [[LSD]] or [[2C-B]] which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.
The cognitive effects of 4-AcO-MET are described by much as somewhat relaxing, yet fast-paced in style with similarities to [[psychedelic]]s such as [[LSD]] or [[2C-B]] which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects.


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*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Analysis enhancement]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Delusion]]'''
*'''[[Effect::Subconscious communication]]'''
*'''[[Effect::Autonomous voice communication]]'''
*'''[[Effect::Ego death]]'''
*'''[[Effect::Ego death]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Emotion enhancement]]'''
*'''[[Effect::Perception of interdependent opposites]]'''
*'''[[Effect::Perception of interdependent opposites]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
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*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Brain zaps]]'''


===Visual effects===
}}
It's worth noting that this compound still produces visual effects at lower doses without any accompanying cognitive effects or "head space."
====Enhancements====
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Pattern recognition enhancement]]'''
*'''[[Effect::Visual acuity enhancement]]'''
 
====Distortions====
*'''[[Effect::Visual drifting|Drifting]]''' ''([[Visual drifting#Melting|melting]], [[Visual drifting#Flowing|flowing]], [[Visual drifting#Breathing|breathing]] and [[Visual drifting#morphing|morphing]])'' - In comparison to other psychedelics, this effect can be described as highly detailed, cartooon-like in style, slow and smooth in motion and static in appearance.
*'''[[Effect::After images]]'''
*'''[[Effect::Colour shifting]]'''
*'''[[Effect::External geometry]]'''
*'''[[Effect::Scenery slicing]]'''
*'''[[Effect::Symmetrical texture repetition]]'''
*'''[[Effect::Tracers]]'''


====[[Effect::Geometry]]====
{{effects/auditory|
The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of [[Psilocin]], [[4-AcO-DMT]] and [[4-HO-MiPT]] but with far stronger synthetic digital undertones reminiscent of [[LSD]] or [[2C-B]]. 4-AcO-MET can be comprehensively described through its [[Geometry#Variations|variations]] as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "natural" and "synthetic" feel to them which is reminiscent of both [[LSD]] and [[Psilocybin]]. Higher dosages are significantly more likely to result in states of [[Effect::8A Geometry|level 8A]] visual geometry over [[8B Geometry|level 8B]].
 
====Hallucinatory states====
4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used [[psychedelic]]s. These effects generally include:
 
*'''[[Effect::Transformations]]'''
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their [[Internal_hallucinations#Variations|variations]] as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, [[Effect::geometry]]-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
 
===Auditory effects===
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory enhancement|Enhancements]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
}}
===Experience reports===
===Experience reports===
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
* [https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]
{{#ask: [[Category:4-AcO-MET]][[Category:Experience]]|format=ul|Columns=2}}
Additional experience reports can be found here:
 
*[https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]


==Toxicity and harm potential==
==Toxicity and harm potential==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-AcO-MET is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-MET suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  
The toxicity and long-term health effects of recreational 4-AcO-MET use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-AcO-MET is a [[research chemical]] with very little history of human usage.  
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 
Anecdotal evidence suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.  
 
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
 
===Tolerance and addiction potential===
===Tolerance and addiction potential===
4-AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  
4-AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  


Tolerance to the effects of 4-AcO-MET are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
Tolerance to the effects of 4-AcO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
 
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Psychedelics}}


==Legal issues==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United States''' - 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
 
*'''United Kingdom''' - 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]]<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3</ref>, which is a Class A drug as a result of the tryptamine catch-all clause.<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e</ref>
*'''Germany''': 4-AcO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-AcO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
*'''Switzerland''': 4-AcO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
*'''United States''': 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}


==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
*[[Psilocin]]
*[[Research chemicals]]
*[[Psychedelic]]
*[[Psychedelics]]
*[[Tryptamine]]
*[[Tryptamine]]
*[[4-HO-MET]]
*[[4-HO-MET]]
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==External links==
==External links==
*[http://en.wikipedia.org/wiki/4-Acetoxy-MET 4-AcO-MET (Wikipedia)]
 
*[http://www.bluelight.org/vb/threads/403781-The-Big-amp-Dandy-4-AcO-MET-Thread 4-AcO-MET (Bluelight)]
*[https://en.wikipedia.org/wiki/4-Acetoxy-MET 4-AcO-MET (Wikipedia)]
*[https://www.erowid.org/experiences/subs/exp_4HOMET.shtml 4-AcO-MET experiences (Erowid)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=5532 4-AcO-MET (Isomer Design)]
*[http://drugs.tripsit.me/4-aco-met 4-AcO-MET (TripSit)]
 
===Discussion===
 
*[http://www.bluelight.org/vb/threads/403781-The-Big-amp-Dandy-4-AcO-MET-Thread The Big & Dandy 4-AcO-MET Thread (Bluelight)]


==References==
==References==
<references/>
<references />
 
[[Category:Psychoactive substance]]
[[Category:Psychedelic]]
[[Category:Tryptamine]]
[[Category:Tryptamine]]
[[Category:Psychedelic]]
[[Category:Psychoactive substance]]
[[Category:Research chemical]]
[[Category:Research chemical]]
{{#set:Featured=true
{{#set:Featured=true
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Retrieved from "http://psy.st/wiki/4-AcO-MET"