4-AcO-MET: Difference between revisions

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~~{{references}}~~

'''4-Acetoxy-N-~~ethyl~~-N-~~methyltryptamine~~''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].

'''4-Acetoxy-N-methyl-N-ethyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].

~~4-AcO-MET~~ is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].

The substance is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].

~~4-AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet".{{citation needed}}~~

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a [[research chemical]] online. It is highly advised to use [[harm reduction practices]] if using this substance.

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==Pharmacology==

It ~~is expected~~ that the ~~compound~~ is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.

It has been suggested that the substance is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.{{citation needed}}

4-AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

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4-AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-AcO-MET ~~are~~ built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.

Tolerance to the effects of 4-AcO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.

===Dangerous interactions===

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 {{SummarySheet}}
 {{SubstanceBox/4-AcO-MET}}
-{{references}}
-'''4-Acetoxy-N-ethyl-N-methyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].
+'''4-Acetoxy-N-methyl-N-ethyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].
--AcO-MET is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].
+The substance is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].
--AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet".{{citation needed}}
 Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a [[research chemical]] online. It is highly advised to use [[harm reduction practices]] if using this substance.
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 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
-It is expected that the compound is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.
+It has been suggested that the substance is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.{{citation needed}}
 -AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
@@ Line 118: / Line 115: @@
 -AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
-Tolerance to the effects of 4-AcO-MET are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
+Tolerance to the effects of 4-AcO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
 ===Dangerous interactions===