4-AcO-MET: Difference between revisions

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~~{{references}}~~

'''4-Acetoxy-N-~~ethyl~~-N-~~methyltryptamine~~''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] ~~chemical~~ class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].

'''4-Acetoxy-N-methyl-N-ethyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].

~~4-AcO-MET~~ is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].

The substance is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].

~~4-AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet".{{citation needed}}~~

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a [[research chemical]] online. It is highly advised to use [[harm reduction practices]] if using this substance.

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==Pharmacology==

It has been suggested that the substance is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.{{citation needed}}

4-AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

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{{effects/base

|{{effects/physical|

*'''[[Effect::Sedation]]''' - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation.

*'''[[Effect::Sedation]]''' - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation. However, the sedation is often considered to be less strong than that of the related compounds [[psilocin]] and [[4-AcO-DMT]].

*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

*'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension.

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}}

===Experience reports===

~~There are currently no anecdotal~~ reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:

Anecdotal reports which describe the effects of this compound within our [[experience index]] include:

* [https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]

{{#ask: [[Category:4-AcO-MET]][[Category:Experience]]|format=ul|Columns=2}}

Additional experience reports can be found here:

*[https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]

==Toxicity and harm potential==

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4-AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 4-AcO-MET ~~are~~ built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.

Tolerance to the effects of 4-AcO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.

===Dangerous interactions===

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==Legal status==

*'''Germany:''' 4-AcO-ME is ~~not a~~ controlled ~~substance~~ under the ~~BtMG.~~<ref>https://www.gesetze-im-internet.de/~~btmg_1981~~/~~anlage_i~~.html</ref> ~~It is legal~~, ~~as long as~~ it is not ~~sold for human consumption~~, ~~according to §2 AMG.~~<ref>https://www.gesetze-im-internet.de/~~amg_1976~~/~~__2~~.html</ref>

*'''United Kingdom:''' 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]]~~<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3</ref>~~, which is a Class A drug as a result of the tryptamine catch-all clause.<ref>~~Misuse of~~ Drugs ~~Act 1971 (Legislation.gov.uk)~~ |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I~~#reference~~-~~M_F_c7632653-ddad-4420-f307-e3da1e36d30e~~</ref>

*'''Germany''': 4-AcO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-AcO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>

*'''United States:''' 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

*'''Switzerland''': 4-AcO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''United Kingdom''': 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>

*'''United States''': 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}

==See also==

*[[Responsible use]]

*[[Research chemicals]]

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==External links==

*[https://en.wikipedia.org/wiki/4-Acetoxy-MET 4-AcO-MET (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=5532 4-AcO-MET (Isomer Design)]

===Discussion===

*[http://www.bluelight.org/vb/threads/403781-The-Big-amp-Dandy-4-AcO-MET-Thread The Big & Dandy 4-AcO-MET Thread (Bluelight)]

==References==

[[Category:Psychoactive substance]]

[[Category:Psychedelic]]

[[Category:Tryptamine]]

~~[[Category:Psychedelic]]~~

~~[[Category:Psychoactive substance]]~~

[[Category:Research chemical]]

{{#set:Featured=true

|RN1=CH₃

@@ Line 1: / Line 1: @@
 {{SummarySheet}}
 {{SubstanceBox/4-AcO-MET}}
-{{references}}
-'''4-Acetoxy-N-ethyl-N-methyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] chemical class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].
+'''4-Acetoxy-N-methyl-N-ethyltryptamine''' (also known as '''4-AcO-MET''', '''Metacetin''', and '''Azomet''') is a lesser-known novel [[Psychoactive class::psychedelic]] substance of [[Chemical class::tryptamine]] class. Members of this group produce [[psilocybin mushroom|psilocybin]]-like [[psychedelic]] effects when [[routes of administration|administered]]. It is structurally related to psychedelic tryptamines like [[4-AcO-DMT]], [[4-AcO-DET]], and [[4-AcO-MiPT]].
--AcO-MET is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].
+The substance is closely related in structure to [[4-HO-MET]], for which it is theorized to act as a [[prodrug]].
--AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet".{{citation needed}}
 Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-AcO-MET, and it has little history of human usage. It is sold as a [[research chemical]] online. It is highly advised to use [[harm reduction practices]] if using this substance.
@@ Line 17: / Line 14: @@
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
+It has been suggested that the substance is quickly hydrolyzed into the free phenolic 4-HO-MET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.{{citation needed}}
 -AcO-MET's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.
@@ Line 25: / Line 24: @@
 {{effects/base
 |{{effects/physical|
-*'''[[Effect::Sedation]]''' - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation.
+*'''[[Effect::Sedation]]''' - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation. However, the sedation is often considered to be less strong than that of the related compounds [[psilocin]] and [[4-AcO-DMT]].
 *'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
 *'''[[Effect::Changes in felt bodily form]]''' - This effect is often accompanied by a sense of warmth and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension.
@@ Line 99: / Line 98: @@
 }}
 ===Experience reports===
-There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
+Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
-* [https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]
+{{#ask: [[Category:4-AcO-MET]][[Category:Experience]]|format=ul|Columns=2}}
+Additional experience reports can be found here:
+*[https://erowid.org/experiences/subs/exp_4AcOMET.shtml Erowid Experience Vaults: 4-AcO-MET]
 ==Toxicity and harm potential==
@@ Line 113: / Line 115: @@
 -AcO-MET is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
-Tolerance to the effects of 4-AcO-MET are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
+Tolerance to the effects of 4-AcO-MET is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-AcO-MET presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-AcO-MET all psychedelics will have a reduced effect.
 ===Dangerous interactions===
@@ Line 121: / Line 123: @@
 ==Legal status==
 {{legalStub}}
-*'''Germany:''' 4-AcO-ME is not a controlled substance under the BtMG.<ref>https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html</ref> It is legal, as long as it is not sold for human consumption, according to §2 AMG.<ref>https://www.gesetze-im-internet.de/amg_1976/__2.html</ref>
-*'''United Kingdom:''' 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]]<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3</ref>, which is a Class A drug as a result of the tryptamine catch-all clause.<ref>Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e</ref>
+*'''Germany''': 4-AcO-MET is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|language=de|issn=0341-1095}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 4-AcO-MET are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
-*'''United States:''' 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
+*'''Switzerland''': 4-AcO-MET is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
+*'''United Kingdom''': 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug [[4-HO-MET]], which is a Class A drug as a result of the tryptamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
+*'''United States''': 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of [[psilocin]] (''4-HO-DMT'') which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.{{citation needed}}
 ==See also==
 *[[Responsible use]]
 *[[Research chemicals]]
@@ Line 134: / Line 139: @@
 ==External links==
 *[https://en.wikipedia.org/wiki/4-Acetoxy-MET 4-AcO-MET (Wikipedia)]
 *[https://isomerdesign.com/PiHKAL/explore.php?id=5532 4-AcO-MET (Isomer Design)]
 ===Discussion===
 *[http://www.bluelight.org/vb/threads/403781-The-Big-amp-Dandy-4-AcO-MET-Thread The Big & Dandy 4-AcO-MET Thread (Bluelight)]
 ==References==
 <references />
+[[Category:Psychoactive substance]]
+[[Category:Psychedelic]]
 [[Category:Tryptamine]]
-[[Category:Psychedelic]]
-[[Category:Psychoactive substance]]
 [[Category:Research chemical]]
 {{#set:Featured=true
 |RN1=CH₃