Pregabalin: Difference between revisions

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*'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss.

*'''[[Effect::Tactile enhancement]]''' - Although the user’s body may feel numb, the sense of touch can be heightened at the same time.

*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.

*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.{{citation needed}}

*'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref>{{cite journal | vauthors=((Eipe, N.)), ((Penning, J.)) | journal=Pain Research & Management : The Journal of the Canadian Pain Society | title=Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | volume=16 | issue=5 | pages=353–356 | date= 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/ | issn=1203-6765}}</ref>

*'''[[Effect::Muscle relaxation]]''' - While the muscle relaxation experienced on pregabalin is not as powerful as that of [[diazepam]] or other [[benzodiazepines]], it is still prominent.

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===Seizure Risk===

Pregabalin has been shown to induce and or increase the risk of seizures at recreational dosages.<ref>https://doi.org/10.1101/cshperspect.a022863</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref>There is little evidence showing there is a concern at medical dosages (600mg and under). This risk may be increased when mixed with other drugs that lower seizure threshold. Caution is recommended when using doses higher than 600mg. Reducing various susceptibility factors may also be beneficial in lowering this risk. Susceptibility factors may include things such as low sodium, lack of sleep, and intensive physical activity.

Pregabalin has been shown to induce and or increase the risk of seizures at recreational dosages.<ref>https://doi.org/10.1101/cshperspect.a022863</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref> There is little evidence showing there is a concern at medical dosages (600mg and under). This risk may be increased when mixed with other drugs that lower seizure threshold. Caution is recommended when using doses of higher than 600mg. Reducing various susceptibility factors may also be beneficial in lowering this risk. Susceptibility factors may include things such as low sodium, lack of sleep, and intensive physical activity.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

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*'''Germany:''' Pregabalin is a prescription medicine, according to Anlage 1 AMVV.<ref>{{Citation | title=AMVV - Verordnung über die Verschreibungspflicht von Arzneimitteln | url=https://www.gesetze-im-internet.de/amvv/BJNR363210005.html}}</ref>

*'''Norway:''' Pregabalin is in prescription schedule B alongside most benzodiazepines and painkillers. It was rescheduled to schedule B from the less restrictive schedule C because of reported recreational use, tolerance development and addiction.<ref>https://nhi.no/for-helsepersonell/nytt-om-legemidler/pregabalin-lyrica-flyttes-til-reseptgruppe-b/</ref>

*'''Poland''' Pregabalin is prescription only substance. Possesion is legal but selling without a permit is illegal.

*'''Sweden:''' Pregabalin is a prescription drug. classified as a controlled substance, as a schedule V drug, since 24 july 2018 <ref>https://lakemedelsverket.se/Alla-nyheter/NYHETER---2018/Pregabalin-narkotikaklassas/</ref>

*'''Switzerland:''' Pregabalin is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.{{citation needed}}

*'''Turkey''': Pregabalin is a 'green prescription' only substance<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref> ~~and illegal when sold or possessed without a prescription.~~{{citation needed}}

*'''Turkey''': Pregabalin is a 'green prescription' only substance and illegal when sold or possessed without a prescription.<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref>{{citation needed}}

*'''United Kingdom:''' The Misuse of Drugs Act 1971 makes it illegal to possess the drug without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2018 | url=https://www.legislation.gov.uk/uksi/2018/1356/article/2/made}}</ref>

*'''United States:''' Pregabalin is in Schedule V, indicating "low potential for abuse." For comparison, benzodiazepines are in Schedule IV.<ref>{{Citation | year=2016 | title=Title 21 CFR - PART 1308 - Section 1308.15 Schedule V | url=http://web.archive.org/web/20161017105621/https://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_15.htm}}</ref>

<br />

== Combinations ==

with [[Memantine]] (anecdotal, N=1)<blockquote>Add-on of 20mg to 30mg Memantine per day to 75mg Pregabalin is equivalent to 300mg Pregabalin (I had tolerance of that much at the time. I have chronic anxiety)</blockquote>

==See also==

@@ Line 44: / Line 44: @@
 *'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss.
 *'''[[Effect::Tactile enhancement]]''' - Although the user’s body may feel numb, the sense of touch can be heightened at the same time.
-*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.
+*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.{{citation needed}}
 *'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref>{{cite journal | vauthors=((Eipe, N.)), ((Penning, J.)) | journal=Pain Research & Management : The Journal of the Canadian Pain Society | title=Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | volume=16 | issue=5 | pages=353–356 | date= 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/ | issn=1203-6765}}</ref>
 *'''[[Effect::Muscle relaxation]]''' - While the muscle relaxation experienced on pregabalin is not as powerful as that of [[diazepam]] or other [[benzodiazepines]], it is still prominent.
@@ Line 163: / Line 162: @@
 ===Seizure Risk===
-Pregabalin has been shown to induce and or increase the risk of seizures at recreational dosages.<ref>https://doi.org/10.1101/cshperspect.a022863</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref>There is little evidence showing there is a concern at medical dosages (600mg and under). This risk may be increased when mixed with other drugs that lower seizure threshold. Caution is recommended when using doses higher than 600mg. Reducing various susceptibility factors may also be beneficial in lowering this risk. Susceptibility factors may include things such as low sodium, lack of sleep, and intensive physical activity.
+Pregabalin has been shown to induce and or increase the risk of seizures at recreational dosages.<ref>https://doi.org/10.1101/cshperspect.a022863</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref><ref>https://doi.org/10.1111/j.0013-9580.2004.455003.x</ref> There is little evidence showing there is a concern at medical dosages (600mg and under). This risk may be increased when mixed with other drugs that lower seizure threshold. Caution is recommended when using doses of higher than 600mg. Reducing various susceptibility factors may also be beneficial in lowering this risk. Susceptibility factors may include things such as low sodium, lack of sleep, and intensive physical activity.
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
@@ Line 190: / Line 189: @@
 *'''Germany:''' Pregabalin is a prescription medicine, according to Anlage 1 AMVV.<ref>{{Citation | title=AMVV - Verordnung über die Verschreibungspflicht von Arzneimitteln | url=https://www.gesetze-im-internet.de/amvv/BJNR363210005.html}}</ref>
 *'''Norway:''' Pregabalin is in prescription schedule B alongside most benzodiazepines and painkillers. It was rescheduled to schedule B from the less restrictive schedule C because of reported recreational use, tolerance development and addiction.<ref>https://nhi.no/for-helsepersonell/nytt-om-legemidler/pregabalin-lyrica-flyttes-til-reseptgruppe-b/</ref>
-*'''Poland''' Pregabalin is prescription only substance. Possesion is legal but selling without a permit is illegal.
 *'''Sweden:''' Pregabalin is a prescription drug. classified as a controlled substance, as a schedule V drug, since 24 july 2018 <ref>https://lakemedelsverket.se/Alla-nyheter/NYHETER---2018/Pregabalin-narkotikaklassas/</ref>
 *'''Switzerland:''' Pregabalin is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.{{citation needed}}
-*'''Turkey''': Pregabalin is a 'green prescription' only substance<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref> and illegal when sold or possessed without a prescription.{{citation needed}}
+*'''Turkey''': Pregabalin is a 'green prescription' only substance and illegal when sold or possessed without a prescription.<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref>{{citation needed}}
 *'''United Kingdom:''' The Misuse of Drugs Act 1971 makes it illegal to possess the drug without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2018 | url=https://www.legislation.gov.uk/uksi/2018/1356/article/2/made}}</ref>
 *'''United States:''' Pregabalin is in Schedule V, indicating "low potential for abuse." For comparison, benzodiazepines are in Schedule IV.<ref>{{Citation | year=2016 | title=Title 21 CFR - PART 1308 - Section 1308.15 Schedule V | url=http://web.archive.org/web/20161017105621/https://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_15.htm}}</ref>
+<br />
+== Combinations ==
+with [[Memantine]] (anecdotal, N=1)<blockquote>Add-on of 20mg to 30mg Memantine per day to 75mg Pregabalin is equivalent to 300mg Pregabalin (I had tolerance of that much at the time. I have chronic anxiety)</blockquote>
 ==See also==