Pregabalin: Difference between revisions
>Utaninja m It has been approved in a later part of the wiki with studies that Pregabalin has seizure concerns. This mark is no longer needed. |
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*'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss. | *'''[[Effect::Physical euphoria]]''' - This component, while prominent in the experience, is generally not as strong as the cognitive euphoria that can be induced. The sensation itself can be described as feelings of physical comfort, warmth and bliss. | ||
*'''[[Effect::Tactile enhancement]]''' - Although the user’s body may feel numb, the sense of touch can be heightened at the same time. | *'''[[Effect::Tactile enhancement]]''' - Although the user’s body may feel numb, the sense of touch can be heightened at the same time. | ||
*'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose. | *'''[[Effect::Muscle twitching]]''' - Somewhat paradoxically, since pregabalin is used as an adjunct treatment for epilepsy, pregabalin, especially in higher doses, can produce muscle spasms.{{citation needed}} Anecdotally, seizures have been reported in overdose.{{citation needed}} | ||
*'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref>{{cite journal | vauthors=((Eipe, N.)), ((Penning, J.)) | journal=Pain Research & Management : The Journal of the Canadian Pain Society | title=Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | volume=16 | issue=5 | pages=353–356 | date= 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/ | issn=1203-6765}}</ref> | *'''[[Effect::Respiratory depression]]''' - While pregabalin may cause respiratory depression, this effect is not as strong as those with [[opioids]] and [[benzodiazepines]].<ref>{{cite journal | vauthors=((Eipe, N.)), ((Penning, J.)) | journal=Pain Research & Management : The Journal of the Canadian Pain Society | title=Postoperative respiratory depression associated with pregabalin: A case series and a preoperative decision algorithm | volume=16 | issue=5 | pages=353–356 | date= 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206785/ | issn=1203-6765}}</ref> | ||
*'''[[Effect::Muscle relaxation]]''' - While the muscle relaxation experienced on pregabalin is not as powerful as that of [[diazepam]] or other [[benzodiazepines]], it is still prominent. | *'''[[Effect::Muscle relaxation]]''' - While the muscle relaxation experienced on pregabalin is not as powerful as that of [[diazepam]] or other [[benzodiazepines]], it is still prominent. | ||
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*'''Sweden:''' Pregabalin is a prescription drug. classified as a controlled substance, as a schedule V drug, since 24 july 2018 <ref>https://lakemedelsverket.se/Alla-nyheter/NYHETER---2018/Pregabalin-narkotikaklassas/</ref> | *'''Sweden:''' Pregabalin is a prescription drug. classified as a controlled substance, as a schedule V drug, since 24 july 2018 <ref>https://lakemedelsverket.se/Alla-nyheter/NYHETER---2018/Pregabalin-narkotikaklassas/</ref> | ||
*'''Switzerland:''' Pregabalin is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.{{citation needed}} | *'''Switzerland:''' Pregabalin is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.{{citation needed}} | ||
*'''Turkey''': Pregabalin is a 'green prescription' only substance<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref> | *'''Turkey''': Pregabalin is a 'green prescription' only substance and illegal when sold or possessed without a prescription.<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref>{{citation needed}} | ||
*'''United Kingdom:''' The Misuse of Drugs Act 1971 makes it illegal to possess the drug without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2018 | url=https://www.legislation.gov.uk/uksi/2018/1356/article/2/made}}</ref> | *'''United Kingdom:''' The Misuse of Drugs Act 1971 makes it illegal to possess the drug without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2018 | url=https://www.legislation.gov.uk/uksi/2018/1356/article/2/made}}</ref> | ||
*'''United States:''' Pregabalin is in Schedule V, indicating "low potential for abuse." For comparison, benzodiazepines are in Schedule IV.<ref>{{Citation | year=2016 | title=Title 21 CFR - PART 1308 - Section 1308.15 Schedule V | url=http://web.archive.org/web/20161017105621/https://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_15.htm}}</ref> | *'''United States:''' Pregabalin is in Schedule V, indicating "low potential for abuse." For comparison, benzodiazepines are in Schedule IV.<ref>{{Citation | year=2016 | title=Title 21 CFR - PART 1308 - Section 1308.15 Schedule V | url=http://web.archive.org/web/20161017105621/https://www.deadiversion.usdoj.gov/21cfr/cfr/1308/1308_15.htm}}</ref> | ||
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== Combinations == | |||
with [[Memantine]] (anecdotal, N=1)<blockquote>Add-on of 20mg to 30mg Memantine per day to 75mg Pregabalin is equivalent to 300mg Pregabalin (I had tolerance of that much at the time. I have chronic anxiety)</blockquote> | |||
==See also== | ==See also== |