Tetrahydrocannabiphorol: Difference between revisions

(5 intermediate revisions by 4 users not shown)

Line 1:

~~{{SubstanceBox~~/~~THCP}}~~

'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist ~~and is believed to have~~ psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

==History and culture==

==Pharmacology==

[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]

==Subjective effects==

The subjective effects have not been fully understood.

The subjective effects have not been fully understood, but it is known that THCP boasts a longer alkyl side chain than THC,<ref>[https://floraflex.com/default/blog/post/unraveling-the-differences-between-thcp-and-thc Unraveling the Differences Between THCP and THC], FloraFlex</ref> which might contribute to it's ability to better connect with human cannabinoid receptors [[CB1]] and [[CB2]].<ref>[https://www.caymanchem.com/news/why-does-alkyl-chain-length-matter Why Does Alkyl Chain Length Matter], Cayman Chemicals</ref>

===Experience reports===

Line 25:

Line 26:

* United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.

*United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.

==External links==

*[https://en.wikipedia.org/wiki/Tetrahydrocannabiphorol Tetrahydrocannabiphorol (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=4614 Tetrahydrocannabiphorol (Isomer Design)]

==References==

@@ Line 1: / Line 1: @@
 {{SummarySheet}}
-{{SubstanceBox/THCP}}
+<br />
 {{stub}}
-'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist and is believed to have psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
+'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ<sup>9</sup>-tetrahydrocannabinol: Δ<sup>9</sup>-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
 ==History and culture==
 ==Pharmacology==
+[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]
 ==Subjective effects==
-The subjective effects have not been fully understood.
+The subjective effects have not been fully understood, but it is known that THCP boasts a longer alkyl side chain than THC,<ref>[https://floraflex.com/default/blog/post/unraveling-the-differences-between-thcp-and-thc Unraveling the Differences Between THCP and THC], FloraFlex</ref> which might contribute to it's ability to better connect with human cannabinoid receptors [[CB1]] and [[CB2]].<ref>[https://www.caymanchem.com/news/why-does-alkyl-chain-length-matter Why Does Alkyl Chain Length Matter], Cayman Chemicals</ref>
 ===Experience reports===
@@ Line 25: / Line 26: @@
 {{legalStub}}
-* United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.
+*United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.
 ==External links==
 *[https://en.wikipedia.org/wiki/Tetrahydrocannabiphorol Tetrahydrocannabiphorol (Wikipedia)]
+*[https://isomerdesign.com/PiHKAL/explore.php?id=4614 Tetrahydrocannabiphorol (Isomer Design)]
 ==References==