Tetrahydrocannabiphorol: Difference between revisions

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[[Tetrahydrocannabiphorol]] (THCP) is a potent ~~cannabinoid~~ that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist ~~and is believed to have~~ psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.

==History and culture==

==Pharmacology==

[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]

==Subjective effects==

The subjective effects have not been fully understood, but it is known that THCP boasts a longer alkyl side chain than THC,<ref>[https://floraflex.com/default/blog/post/unraveling-the-differences-between-thcp-and-thc Unraveling the Differences Between THCP and THC], FloraFlex</ref> which might contribute to it's ability to better connect with human cannabinoid receptors [[CB1]] and [[CB2]].<ref>[https://www.caymanchem.com/news/why-does-alkyl-chain-length-matter Why Does Alkyl Chain Length Matter], Cayman Chemicals</ref>

===Experience reports===

There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].

==Toxicity and harm potential==

===Tolerance and addiction potential===

===Dangerous interactions===

==Legal status==

*United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.

==External links==

*[https://en.wikipedia.org/wiki/Tetrahydrocannabiphorol Tetrahydrocannabiphorol (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=4614 Tetrahydrocannabiphorol (Isomer Design)]

==References==

[[Category:Cannabis (genus)| ]]

[[Category:Entheogen]]

[[Category:Depressant]]

[[Category:Stimulant]]

[[Category:Cannabinoid]]

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-[[Tetrahydrocannabiphorol]] (THCP) is a potent cannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist and is believed to have psychoactive effects. Initial studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
+{{SummarySheet}}
+<br />
+{{stub}}
+'''Tetrahydrocannabiphorol''' ('''THCP''') is a potent phytocannabinoid that is structurally similar to delta-9-THC, the main psychoactive compound in cannabis. Like THC, THCP is a CB1 and CB2 receptor agonist with psychoactive effects. Initial in-vitro binding assay studies suggest that THCP may be up to 30 times more potent than delta-9-THC,<ref name="Citti et al 2019">{{cite journal | vauthors = Citti C, Linciano P, Russo F, Luongo L, Iannotta M, Maione S, Laganà A, Capriotti AL, Forni F, Vandelli MA, Gigli G, Cannazza G | title = A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ<sup>9</sup>-tetrahydrocannabinol: Δ<sup>9</sup>-Tetrahydrocannabiphorol | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 20335 | date = December 2019 | pmid = 31889124 | pmc = 6937300 | doi = 10.1038/s41598-019-56785-1 | bibcode = 2019NatSR...920335C }}</ref><ref>https://www.livescience.com/new-potent-cannabinoid.html</ref> potentially leading to more pronounced psychoactive effects. However, the full extent of THCP's psychoactivity and how it compares to THC is still being researched.
+==History and culture==
+==Pharmacology==
+[[File:Tetrahydrocannabiphorol_Ki.png|thumbnail|250px|right|Binding affinities of THCP for CB1 and CB2 receptors, with D8/D9 THC comparisons.<ref name="Citti et al 2019"></ref>]]
+==Subjective effects==
+The subjective effects have not been fully understood, but it is known that THCP boasts a longer alkyl side chain than THC,<ref>[https://floraflex.com/default/blog/post/unraveling-the-differences-between-thcp-and-thc Unraveling the Differences Between THCP and THC], FloraFlex</ref> which might contribute to it's ability to better connect with human cannabinoid receptors [[CB1]] and [[CB2]].<ref>[https://www.caymanchem.com/news/why-does-alkyl-chain-length-matter Why Does Alkyl Chain Length Matter], Cayman Chemicals</ref>
+===Experience reports===
+There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]].
+==Toxicity and harm potential==
+===Tolerance and addiction potential===
+===Dangerous interactions===
+==Legal status==
+{{legalStub}}
+*United States: THCP is not currently classified under any drug schedule in the United States, but it is federally legal.
+==External links==
+*[https://en.wikipedia.org/wiki/Tetrahydrocannabiphorol Tetrahydrocannabiphorol (Wikipedia)]
+*[https://isomerdesign.com/PiHKAL/explore.php?id=4614 Tetrahydrocannabiphorol (Isomer Design)]
+==References==
+{{reflist|2}}
+[[Category:Cannabis (genus)| ]]
+[[Category:Entheogen]]
+[[Category:Depressant]]
+[[Category:Stimulant]]
+[[Category:Cannabinoid]]
+{{#set:Featured=true}}