Talk:Atomoxetine: Difference between revisions

== Atomoxetine is a medication used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). It is a selective norepinephrine reuptake inhibitor, working by increasing norepinephrine levels in the brain, specifically targeting the prefrontal cortex, aiding in improving attention, impulse control, and reducing hyperactivity. Unlike some medications for ADHD, such as Methylphenidate and Lisdexamfetamine, Atomoxetine is not a stimulant, making it a preferred option for patients who do not respond well to stimulants or have concerns about their use, such as dependency and abuse. Atomoxetine is a long-acting treatment option, meaning that a single daily dose can provide benefits throughout the day, eliminating the need for multiple doses. This notion was further strengthened by data showing that atomoxetine may be preferred in the treatment of addictions because it does not increase dopamine concentrations in striatum and nucleus accumbens, suggesting a low abuse potential. ==

=== It is usually administered in the form of extended-release capsules, allowing for a single daily dose. The most common side effects include headache, nausea, drowsiness, dizziness, and trouble sleeping. It may take a few weeks for the benefits of atomoxetine to be fully realized, and it is important to follow medical guidance for dose adjustments and monitoring. ===

=== Although it is generally well tolerated, atomoxetine may increase the risk of suicidal thoughts or behaviors in some individuals, especially at the beginning of treatment. Therefore, it is essential to closely monitor patients, especially children and adolescents, during the use of this medication. ===

*In Australia, Canada, Italy, Portugal, Romania, Spain, Switzerland and the US, atomoxetine is sold under the brand name Strattera. In Brazil is sold under the name Atentah. In the Czech Republic it is sold under brand names including Mylan. In Poland, it is sold under the brand name Auroxetyn.

*Studies suggest that atomoxetine's action as an antidepressant also provides some effectiveness in relation to depressive and anxious symptoms, as well as in reducing the craving for cannabis and nicotine.

= Drug Interations =

*Marijuana and CBD oil: The interaction between atomoxetine and marijuana (even if it's just CBD oil) can lead to an increase in atomoxetine levels in the body, enhancing side effects and intensifying the risks of suicidal thoughts, mood swings, nausea, abdominal discomfort, as well as paranoia and anxiety, especially in predisposed individuals. Additionally, both can cause cardiovascular changes and hypertension in susceptible individuals.

*Selective serotonin reuptake inhibitors (SSRIs): The combination of selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) can result in Serotonin Syndrome, characterized by severe symptoms such as confusion, agitation, and increased heart rate due to excess serotonin in the brain. Additionally, there is an increased risk of side effects such as nausea, insomnia, and dizziness, as well as cardiovascular complications, including cardiac arrhythmias and hypertension. Although less common, the combination can lead to serious adverse reactions such as hypertensive crises or acute cardiovascular events.

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*Amphetamines: The combination can  increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting).