Tizanidine: Difference between revisions

(3 intermediate revisions by 2 users not shown)

Line 3:

'''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a [[depressant]] substance of the ~~imidazoline~~ class closely related to [[clonidine]]. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of [[baclofen]] or [[diazepam]] <ref> Wagstaff AJ, Bryson HM. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. PMID: 9074844. </ref>.

'''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a [[depressant]] substance of the [[chemical class::arylaminoimidazoline]] class closely related to [[clonidine]]. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of [[baclofen]] or [[diazepam]] <ref> Wagstaff AJ, Bryson HM. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. PMID: 9074844. </ref>.

Tizanidine is a central α<sub>2</sub> adrenergic agonist. The relationship between the α<sub>2</sub> receptor agonism and the spasmolytic function of tizanidine is not fully understood <ref> Katzung, Bertram G. (30 November 2017). Basic & clinical pharmacology. Katzung, Bertram G. (Fourteenth ed.). New York. p. 487. ISBN 9781259641152. OCLC 1015240036 </ref> .

Line 141:

==Legal status==

* '''Austria:''' Tizanidine is available by prescription only.

* '''Turkey:''' Tizanidine is available in pharmacies without prescription.

* '''United States:''' Tizanidine is available by prescription only.

Line 156:

Line 157:

*[https://isomerdesign.com/pihkal/explore/15021 Tizanidine (IsomerDesign)]

*[https://erowid.org/experiences/subs/exp_Tizanidine.shtml Tizanidine (Erowid Vault)]

*[https://go.drugbank.com/drugs/DB00697 Tizanidine (DrugBank)]

==References==

[[Category:Psychoactive substance]][[Category:~~Proofread~~]][[Category:~~Approval~~]]

[[Category:Psychoactive substance]]

[[Category:Arylaminoimidazoline]]

[[Category:Depressant]]

@@ Line 3: / Line 3: @@
 {{SubstanceBox/Tizanidine}}
-'''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a [[depressant]] substance of the imidazoline class closely related to [[clonidine]]. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of [[baclofen]] or [[diazepam]] <ref> Wagstaff AJ, Bryson HM. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. PMID: 9074844. </ref>.
+'''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a [[depressant]] substance of the [[chemical class::arylaminoimidazoline]] class closely related to [[clonidine]]. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of [[baclofen]] or [[diazepam]] <ref> Wagstaff AJ, Bryson HM. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. PMID: 9074844. </ref>.
 Tizanidine is a central α<sub>2</sub> adrenergic agonist. The relationship between the α<sub>2</sub> receptor agonism and the spasmolytic function of tizanidine is not fully understood <ref> Katzung, Bertram G. (30 November 2017). Basic & clinical pharmacology. Katzung, Bertram G. (Fourteenth ed.). New York. p. 487. ISBN 9781259641152. OCLC 1015240036 </ref> .
@@ Line 141: / Line 141: @@
 ==Legal status==
 {{LegalStub}}
+* '''Austria:''' Tizanidine is available by prescription only.
 * '''Turkey:''' Tizanidine is available in pharmacies without prescription.
 * '''United States:''' Tizanidine is available by prescription only.
@@ Line 156: / Line 157: @@
 *[https://isomerdesign.com/pihkal/explore/15021 Tizanidine (IsomerDesign)]
 *[https://erowid.org/experiences/subs/exp_Tizanidine.shtml Tizanidine (Erowid Vault)]
+*[https://go.drugbank.com/drugs/DB00697 Tizanidine (DrugBank)]
 ==References==
 <references />
-[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]
+[[Category:Psychoactive substance]]
+[[Category:Arylaminoimidazoline]]
+[[Category:Depressant]]