F-Phenibut: Difference between revisions

'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''', '''Baflofen''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.

 

As with [[phenibut]], F-Phenibut is a derivative of [[GABA]], except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers.<ref>{{cite journal | vauthors=((Dambrova, M.)), ((Zvejniece, L.)), ((Liepinsh, E.)), ((Cirule, H.)), ((Zharkova, O.)), ((Veinberg, G.)), ((Kalvinsh, I.)) | journal=European Journal of Pharmacology | title=Comparative pharmacological activity of optical isomers of phenibut | volume=583 | issue=1 | pages=128–134 | date=31 March 2008 | issn=0014-2999 | doi=10.1016/j.ejphar.2008.01.015}}</ref> It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group).<ref>{{cite journal | vauthors=((Shulgina, G. I.)) | journal=The Pavlovian Journal of Biological Science | title=On neurotransmitter mechanisms of reinforcement and internal inhibition | volume=21 | issue=4 | pages=129–140 | date= December 1986 | issn=0093-2213 | doi=10.1007/BF02734511}}</ref> Additionally, the widely prescribed gabapentinoid [[pregabalin]] also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group in the S configuration. F-Phenibut is water soluble.

[[F-Phenibut/Summary|F-phenibut]] acts as a potent agonist of the GABA-B receptor and in this regard is more similar to [[baclofen]] than [[phenibut]].<ref>{{cite journal | vauthors=((Irie, T.)), ((Yamazaki, D.)), ((Kikura-Hanajiri, R.)) | journal=European Journal of Pharmacology | title=F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells | volume=884 | pages=173437 | date=5 October 2020 | url=https://www.sciencedirect.com/science/article/pii/S001429992030529X | issn=0014-2999 | doi=10.1016/j.ejphar.2020.173437}}</ref>

It is also possible that F-Phenibut binds to the α2δ-1 site of voltage-gated calcium channels in a manner similar to that of other [[gabapentinoids]]. By binding to this site, F-Phenibut may reduce the release of several excitatory [[neurotransmitter]]s, including [[glutamate]], [[substance P]], [[acetylcholine]], and [[norepinephrine]]. This, in turn, increases [[GABA]]ergic activity.{{citation needed}} As the GABA system is the most prevalent inhibitory receptor set within the brain{{citation needed}}, its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.

*'''[[Effect::Headaches]]''' - Moderate to high doses have been reported to induce a mild to strong headache, typically many hours after dosing or during the comedown period.

*'''[[Effect::Compulsive redosing]]''' - This component is highly pronounced in comparison to [[phenibut]].

*'''[[Effect::Analysis suppression]]''' - High doses will usually induce a state of mild stupor and confusion.

 

*[https://erowid.org/experiences/subs/exp_Smarts_Fluorophenibut.shtml Erowid Experience Vaults: Fluorophenibut]

[[Withdrawal effects|Withdrawal symptoms]] likely include severe [[anxiety]], nervousness, hallucinations, tremors, agitation, [[dizziness]], tension, irritation, [[increased heart rate|rapid heartbeat]], [[physical fatigue|fatigue]], loss of appetite, [[nausea]], vomiting, [[psychosis]], and [[insomnia]] in a similar manner to phenibut.<ref name="three">{{cite book | vauthors=((Group, D. W.)) | date=25 February 2015 | title=Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances, 2d ed. | publisher=McFarland | isbn=9780786441426}}</ref>

 

*'''United Kingdom:''' It may be illegal to produce, supply, or import this substance under the Psychoactive Substance Act 2016, which blanketly applies the aforementioned restrictions on all "psychoactive substances" with exemptions for alcohol, nicotine and "medicinal products."<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref>

<references />

 

[[Category:Gamma-Amino acid]]

[[Category:Phenethylamine]]