Lysergamides: Difference between revisions

{{stub}}[[File:Lysergamide1.png|thumb|right|250px|Substitutive structure of a ''lysergamide'']]

'''Lysergamides''' are amides of lysergic acid.

Ergoline refers to a class of compounds derived from alkaloids of a group of fungi known as ''ergot'' in the ''claviceps'' genus. These compounds typically have have strong [[psychedelic]] effects.

Lysergamides are polycyclic amides which have both [[phenethylamine]] and [[tryptamine]] groups embedded within their structure and a carboxamide group attached to carbon number eight. Varying the substituent attached to the nitrogen atoms has produced a variety of drugs with [[psychedelic]] effects as well as prescription drugs for treating headaches and inducing labor. Hydroxylation of the aromatic ring is one method of metabolizing lysergamides in humans and produces compounds with greater affinity to dopamine receptors.

{{Main|Serotonergic psychedelic}}

! scope="col" | '''Compound'''

! scope="col" style="width: 50px;" | '''R_N1'''

! scope="col" style="width: 50px;" | '''R_N2'''

! scope="col" style="width: 50px;" | '''R₁'''

! scope="col" style="width: 50px;" | '''R₆'''

! scope="col" | '''Structure'''

| [[1P-ETH-LAD]] || CH₂CH₃ || CH₂CH₃ || C=OCH₂CH₃ || CH₂CH₃ || [[File:1P-ETH-LAD.png|170px]]

| [[1P-LSD]] || CH₂CH₃ || CH₂CH₃ || C=OCH₂CH₃ || CH₃ ||[[File:1P-LSD.png|171px]]

| [[ALD-52]] || CH₂CH₃ || CH₂CH₃ || C=OCH₃ || CH₃ || [[File:ALD-52.png|170px]]

| [[AL-LAD]] || CH₂CH₃ || CH₂CH₃ || H || CH₂CH=CH₂ || [[File:AL-LAD.png|170px]]

| [[Ergotamine]] || * || H || H || CH₃ || [[File:Ergotamine2.png|170px]]

| [[ETH-LAD]] || CH₂CH₃ || CH₂CH₃ || H || CH₂CH₃ || [[File:ETH-LAD.png|170px]]

| [[LSA]] || H || H || H || CH₃ || [[File:LSA.png|170px]]

| [[LSD]] || CH₂CH₃ || CH₂CH₃ || H || CH₃ || [[File:LSD.png|170px]]

| LSH || CH(OH)CH₃ || H || H || CH₃ || [[File:LSH.png|170px]]

| LSM-775 || CH₂CH₂O- || CH₂CH₂- || H || CH₃ || [[File:LSM-775.png|170px]]

| [[LSZ]] || CH(CH₃)CH₂- || CH(CH₃)CH₂- || H || CH₃ || [[File:LSZ.png|170px]]

| PARGY-LAD || CH₂CH₃ || CH₂CH₃ || H || CH₂C≡CH || [[File:PARGY-LAD.png|170px]]

| [[PRO-LAD]] || CH₂CH₃ || CH₂CH₃ || H || CH₂CH₂CH₃ || [[File:PRO-LAD.png|170px]]

*[[Wikipedia:Lysergamide|Lysergamide (Wikipedia)]]

*[[Phenethylamine]]

*[[Tryptamine]]