5-MeO-MiPT: Difference between revisions

5-MeO-MiPT's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT_2A receptor]] as a [[Agonist#Agonists|partial agonist]]<ref name="pmid17223101">{{cite journal|title=The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain|pmid=17223101|volume=559|issue=2–3|year=2007|pages=132-137|first1=F.|last1=Nagai|first2=R.|last2=Nonaka|first3=K.|last3=Satoh|first4=H.|last4=Kamimura|journal=European Journal of Pharmacology|issn=0014-2999|eissn=1879-0712|oclc=01568459|doi=10.1016/j.ejphar.2006.11.075}}</ref><ref name="Repke1985" /> and additional mechanisms of action such as the inhibition of [[MAOI|MAO]] (i.e. digestive enzymes in the stomach) have also been speculated upon, though this has yet to be demonstrated scientifically. While 5-MeO-MiPT binds most strongly to 5-HT1A receptors, it also shows fairly strong binding affinity to the SERT and NET, thereby acting as a moderately potent serotonin-norepinephrine reuptake inhibitor.<ref>{{cite journal | vauthors=((Ray, T. S.)) | journal=PLoS ONE | title=Correction: Psychedelics and the Human Receptorome | volume=5 | issue=3 | date=4 March 2010 | url=https://dx.plos.org/10.1371/annotation/e580a864-cf13-40c2-9bd9-b9687a6f0fe4 | issn=1932-6203 | doi=10.1371/annotation/e580a864-cf13-40c2-9bd9-b9687a6f0fe4}}</ref> These mechanisms may help explain why there are many anecdotal reports of anti-depressant and anxiolytic effects from modest doses of this compound. For example, SNRIs such as venlafaxine are commonly prescribed to treat depression, and the 5-HT1A agonist buspirone is prescribed primarily for treatment of anxiety.

*'''[[Effect::Increased libido]]'''