Lorazepam: Difference between revisions

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==Subjective effects==

{{effects/base

|{{effects/physical|

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}}

|{{effects/cognitive|

The cognitive effects of lorazepam can be broken down into several components which progressively intensify proportional to dosage. The general head space of lorazepam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical [[depressant]]s cognitive effects.

The cognitive effects of lorazepam can be broken down into several components which progressively intensify proportional to dosage. The general head space of lorazepam is described by many as one of intense sedation and decreased inhibition. In recreational doses it can be very discombobulating. It contains a large number of typical [[depressant]]s cognitive effects. Often compared to [[alprazolam]], lorazepam is noted for having a more sedation and sleepiness but less [[Anxiety reduction|anxiolytic]] effects.

The most prominent of these cognitive effects generally include:

*'''[[Effect::Analysis suppression]]'''

*'''[[Effect::Anxiety suppression]]'''

*'''[[Effect::Anxiety suppression]]''' - Not as prominent as with alprazolam, [[clonazepam]] or [[diazepam]].

*'''[[Effect::Appetite enhancement]]'''

*'''[[Effect::Compulsive redosing]]'''

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*'''[[Effect::Disinhibition]]'''

*'''[[Effect::Dream potentiation]]'''

*'''[[Effect::Emotionality suppression|Emotion suppression]]''' - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of [[antipsychotic]]s.

*'''[[Effect::Emotionality suppression|Emotion suppression]]''' - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of [[antipsychotic]]s. This particular component may even be more prominent on lorazepam than other common benzodiazepines.

*'''[[Effect::Memory suppression]]'''

**'''[[Effect::Amnesia]]'''

*'''[[Effect::Thought deceleration]]'''

*'''[[Effect::Thought deceleration]]''' - This can often be visibly clear to onlookers just during verbal exchanges even on light-medium doses without [[Drug tolerance|tolerance]].

*'''[[Effect::Black out]]'''

}}

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*'''Austria''': Lorazepam is legal for medical use under the AMG (Arzneimittelgesetz Österreich) and illegal when sold or possessed without a prescription under the SMG (Suchtmittelgesetz Österreich).{{citation needed}}

*'''Canada''': Lorazepam is listed in Schedule IV of the Controlled Drugs and Substances Act in Canada.{{citation needed}}

*'''China:''' Lorazepam is a controlled Class II psychotropic substances.<ref>《麻醉药品和精神药品品种目录（2023版）》-国有资产管理处 (tjnu.edu.cn)</ref> Prescriptions for psychotropic substances in Class II are generally limited to a 7-day supply.<ref>卫生部关于印发《麻醉药品、精神药品处方管理规定》的通知　　麻醉药品、精神药品处方管理规定__2006年第28号国务院公报_中国政府网 (www.gov.cn)</ref>

*'''Germany''': Lorazepam is controlled under Anlage III BtMG (''Narcotics Act, Schedule III'')<ref name="BtMG_AnlageIII">{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_iii.html|title=Anlage III BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 26, 2019|language=de}}</ref> as of August 1, 1986.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl186s1099.pdf|title=Zweite Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 1986 Teil I Nr. 36|publication-date=July 29, 1986|access-date=December 26, 2019|language=de}}</ref> It can only be prescribed on a narcotic prescription form, except preparations which contain up to 2.5 mg lorazepam in each dosage form.<ref name="BtMG_AnlageIII"></ref>

*'''New Zealand''': Lorazepam is a Class C Controlled drug under the Misuse of Drugs Act 1975.<ref>http://legislation.govt.nz/act/public/1975/0116/91.0/DLM436723.html</ref>

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*'''Turkey''': Lorazepam is a 'green prescription' only substance<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref> and illegal when sold or possessed without a prescription.{{citation needed}}

*'''United Kingdom''': Lorazepam is classified as a controlled substance and is listed under Schedule IV, Part I (CD Benz POM) of the Misuse of Drugs Regulations 2001, allowing possession with a valid prescription. The Misuse of Drugs Act 1971 makes it illegal to possess it without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=Drugs licensing | url=https://www.gov.uk/government/collections/drugs-licensing}}</ref>

*'''United States''': Lorazepam is a Schedule IV drug under the Controlled Substances Act.~~{{citation needed}}~~

*'''United States''': Lorazepam is a Schedule IV drug under the Controlled Substances Act.<ref>Drug Scheduling, DEA | https://www.dea.gov/drug-information/drug-scheduling</ref>

*'''Poland''': Lorazepam is controlled under act of psychotropic substances list IV-P Group of "''low potential for abuse''" (with other benzodiazepines in this group). It's legal for medical, scientific and manufacturing purposes. <ref>[https://pl.wikipedia.org/wiki/Wykaz_środków_odurzających_i_substancji_psychotropowych ''Polish wiki about controlled substances (no english translation)'']</ref>

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*[http://www.erowid.org/pharms/lorazepam Lorazepam (Erowid Vault)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=3020 Lorazepam (Isomer Design)]

*[https://go.drugbank.com/drugs/DB00186 Lorazepam (DrugBank)]

*[https://www.drugs.com/lorazepam.html Lorazepam (Drugs.com)]

*[https://drugs-forum.com/wiki/Lorazepam Lorazepam (Drugs-Forum)]

==References==

@@ Line 21: / Line 21: @@
 ==Subjective effects==
 {{Preamble/SubjectiveEffects}}
 {{effects/base
 |{{effects/physical|
@@ Line 40: / Line 41: @@
 }}
 |{{effects/cognitive|
-The cognitive effects of lorazepam can be broken down into several components which progressively intensify proportional to dosage. The general head space of lorazepam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical [[depressant]]s cognitive effects.
+The cognitive effects of lorazepam can be broken down into several components which progressively intensify proportional to dosage. The general head space of lorazepam is described by many as one of intense sedation and decreased inhibition. In recreational doses it can be very discombobulating. It contains a large number of typical [[depressant]]s cognitive effects. Often compared to [[alprazolam]], lorazepam is noted for having a more sedation and sleepiness but less [[Anxiety reduction|anxiolytic]] effects.
 The most prominent of these cognitive effects generally include:
 *'''[[Effect::Analysis suppression]]'''
-*'''[[Effect::Anxiety suppression]]'''
+*'''[[Effect::Anxiety suppression]]''' - Not as prominent as with alprazolam, [[clonazepam]] or [[diazepam]].
 *'''[[Effect::Appetite enhancement]]'''
 *'''[[Effect::Compulsive redosing]]'''
@@ Line 50: / Line 51: @@
 *'''[[Effect::Disinhibition]]'''
 *'''[[Effect::Dream potentiation]]'''
-*'''[[Effect::Emotionality suppression|Emotion suppression]]''' - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of [[antipsychotic]]s.
+*'''[[Effect::Emotionality suppression|Emotion suppression]]''' - Although this compound primarily suppresses anxiety, it also dulls other emotions in a manner which is distinct but less intensive than that of [[antipsychotic]]s. This particular component may even be more prominent on lorazepam than other common benzodiazepines.
 *'''[[Effect::Memory suppression]]'''
 **'''[[Effect::Amnesia]]'''
-*'''[[Effect::Thought deceleration]]'''
+*'''[[Effect::Thought deceleration]]''' - This can often be visibly clear to onlookers just during verbal exchanges even on light-medium doses without [[Drug tolerance|tolerance]].
+*'''[[Effect::Black out]]'''
 }}
@@ Line 96: / Line 98: @@
 *'''Austria''': Lorazepam is legal for medical use under the AMG (Arzneimittelgesetz Österreich) and illegal when sold or possessed without a prescription under the SMG (Suchtmittelgesetz Österreich).{{citation needed}}
 *'''Canada''': Lorazepam is listed in Schedule IV of the Controlled Drugs and Substances Act in Canada.{{citation needed}}
+*'''China:''' Lorazepam is a controlled Class II psychotropic substances.<ref>《麻醉药品和精神药品品种目录（2023版）》-国有资产管理处 (tjnu.edu.cn)</ref> Prescriptions for psychotropic substances in Class II are generally limited to a 7-day supply.<ref>卫生部关于印发《麻醉药品、精神药品处方管理规定》的通知　　麻醉药品、精神药品处方管理规定__2006年第28号国务院公报_中国政府网 (www.gov.cn)</ref>
 *'''Germany''': Lorazepam is controlled under Anlage III BtMG (''Narcotics Act, Schedule III'')<ref name="BtMG_AnlageIII">{{cite web|url=https://www.gesetze-im-internet.de/btmg_1981/anlage_iii.html|title=Anlage III BtMG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 26, 2019|language=de}}</ref> as of August 1, 1986.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl186s1099.pdf|title=Zweite Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 1986 Teil I Nr. 36|publication-date=July 29, 1986|access-date=December 26, 2019|language=de}}</ref> It can only be prescribed on a narcotic prescription form, except preparations which contain up to 2.5&nbsp;mg lorazepam in each dosage form.<ref name="BtMG_AnlageIII"></ref>
 *'''New Zealand''': Lorazepam is a Class C Controlled drug under the Misuse of Drugs Act 1975.<ref>http://legislation.govt.nz/act/public/1975/0116/91.0/DLM436723.html</ref>
@@ Line 102: / Line 105: @@
 *'''Turkey''': Lorazepam is a 'green prescription' only substance<ref>YEŞİL REÇETEYE TABİ İLAÇLAR | https://www.titck.gov.tr/storage/Archive/2019/contentFile/01.04.2019%20SKRS%20Ye%C5%9Fil%20Re%C3%A7eteli%20%C4%B0la%C3%A7lar%20Aktif%20SON%20-%20G%C3%9CNCEL_58b1ff4a-2e1c-4867-bad7-eec855d6162a.pdf</ref> and illegal when sold or possessed without a prescription.{{citation needed}}
 *'''United Kingdom''': Lorazepam is classified as a controlled substance and is listed under Schedule IV, Part I (CD Benz POM) of the Misuse of Drugs Regulations 2001, allowing possession with a valid prescription. The Misuse of Drugs Act 1971 makes it illegal to possess it without a prescription and, for such purposes, it is classified as a Class C drug.<ref>{{Citation | title=Drugs licensing | url=https://www.gov.uk/government/collections/drugs-licensing}}</ref>
-*'''United States''': Lorazepam is a Schedule IV drug under the Controlled Substances Act.{{citation needed}}
+*'''United States''': Lorazepam is a Schedule IV drug under the Controlled Substances Act.<ref>Drug Scheduling, DEA | https://www.dea.gov/drug-information/drug-scheduling</ref>
 *'''Poland''': Lorazepam is controlled under act of psychotropic substances list IV-P Group of "''low potential for abuse''" (with other benzodiazepines in this group). It's legal for medical, scientific and manufacturing purposes. <ref>[https://pl.wikipedia.org/wiki/Wykaz_środków_odurzających_i_substancji_psychotropowych ''Polish wiki about controlled substances (no english translation)'']</ref>
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 *[http://www.erowid.org/pharms/lorazepam Lorazepam (Erowid Vault)]
 *[https://isomerdesign.com/PiHKAL/explore.php?id=3020 Lorazepam (Isomer Design)]
+*[https://go.drugbank.com/drugs/DB00186 Lorazepam (DrugBank)]
+*[https://www.drugs.com/lorazepam.html Lorazepam (Drugs.com)]
+*[https://drugs-forum.com/wiki/Lorazepam Lorazepam (Drugs-Forum)]
 ==References==