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Talk:Tilidine: Difference between revisions

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m 0xea moved page Tilidin to Tilidine: corrected name
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{{decree|type=notice|message=Trying to fix current Tilidine article not showing. This version is by far not Ideal}}
{{headerpanel|{{Approval}}}}
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{{headerpanel|{{DepressantOD|opiates}}}}
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{{SubstanceBox/Tilidine}}
{{SummarySheet}}
{{SummarySheet}}
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    <!-- Nomenclature -->
    |NameCommon=[[common name::Tilidine]], [[common name::Tilidin]], [[common name::Darby]], [[common name::Valoron]], [[common name::Generika]]
    |NameSubstitution=Tilidin
    |NameSystematic=(E)-2-(Dimethylamino)- 1-phenyl-cyclohex-3-en- 1-carbonsäureethylester


    <!-- Class Membership -->
'''Tilidine''' (known under brand names including '''Valoron''', '''Valtran''', '''Tilicomp''') is a synthetic [[opioid]] analgesic. Tilidine is mainly used in some European countries such as Germany, Belgium, Luxembourg, Switzerland and also South Africa. As is the case with other opioids, it is also commonly used as a recreational drug.{{citation needed}}
    |EffectClass=[[Opioid]]
    |ChemicalClass=[[Opioid]]


    <!-- Dosage/Duration -->
==Pharmacology==
    |OralROA=true
Tilidine itself is only a weak µ-opioid agonist. Its pharmacological activity when administered is mediated by its active major metabolite nortilidine, which is further metabolised to the also active bisnortilidine. Tilidine is therefore a prodrug. The demethylation of tilidine to nortilidine and bisnortilidine occures in the liver and is catalysed  by the Cytochrome P450 family of enzymes, mainly by CYP3A4 CYP2D6 and CYP2C19. <ref>J. Weiss, E. Sawa, K.-D. Riedel, W. E. Haefeli, G. Mikus: In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6. In: Naunyn-Schmiedeberg’s Arch. Pharmacol. 378, 2008, S. 275–282, doi:10.1007/s00210-008-0294-7.</ref>
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    |OralROA_Light=[[Oral min light dose::25]] - [[Oral max light dose::50]] mg
    |OralROA_Common=[[Oral min common dose::50]] - [[Oral max common dose::100]] mg
    |OralROA_Strong=[[Oral min strong dose::100]] - [[Oral max strong dose::150]] mg
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    |OralROA_Aftereffects=[[Oral min afterglow time::1]] - [[Oral max afterglow time::12]] [[Oral afterglow time units::hours]]
}}


==Subjective effects==
==Subjective effects==
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|{{effects/physical|
|{{effects/physical|
[[Subjective effect index#Physical effects|here]].
*'''[[Effect::Sedation]]'''  
*'''[[Effect::Sedation]]'''  
*'''[[Effect::Physical euphoria]]'''
*'''[[Pain relief]]'''
*'''[[Itchiness]]'''
*'''[[Constipation]]'''
*'''[[Cough suppression]]'''
*'''[[Decreased libido]]'''
*'''[[Difficulty urinating]]'''
*'''[[Nausea]]'''
*'''[[Stomach cramps]]'''
*'''[[Pupil constriction]]'''
*'''[[Orgasm suppression]]'''
}}
}}


|{{effects/cognitive|
|{{effects/cognitive|
[[Subjective effect index#Cognitive effects|here]].
*'''[[Cognitive euphoria]]'''
*'''[[Effect::Euphoria]]'''  
*'''[[Anxiety suppression]]'''
*'''[[Effect::Emotional numbing]]'''
*'''[[Compulsive redosing]]'''
*'''[[Dream potentiation]]'''
*'''[[Increased music appreciation]]'''
}}
}}
}}
{{effects/auditory|
[[Subjective effect index#Auditory effects|here]].
*'''[[Effect::less intense audio stimulation]]'''
}}}}


==Toxicity and harm potential==
==Toxicity and harm potential==
{{toxicity}}
{{toxicity}}
Death may occur
 
===Lethal dosage===
===Lethal dosage===
Depends on the Individual
Death with as little as 750 mg has been reported, in combination with barbiturates.
===Tolerance and addiction potential===
 
Strong Physical and Psychological addiction potential
===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions}}
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==External links==
==External links==
(List along order below)
*[https://en.wikipedia.org/wiki/Tilidine Tilidine (Wikipedia)]
* [https://en.wikipedia.org/wiki/Tilidine (Wikipedia)]
*[https://isomerdesign.com/pihkal/explore/10836 Tilidine (Isomer Design)]
*[https://go.drugbank.com/drugs/DB13787 Tilidine (DrugBank)]
*[https://www.apotheken-umschau.de/medikamente/beipackzettel/tilidin-comp-stada-50-mg4-mg-retardtabletten-2003310.html Tilidin (Offical German pharmacy Journal)]


==References==
==References==
<references />
<references />


[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]]
[[Category:Psychoactive substance]]
[[Category:Proofread]]
[[Category:Approval]]
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