25x-NBOMe: Difference between revisions

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{{Warning/25x-NBOMe}}
{{headerpanel|{{Warning/25x-NBOMe}}}}
[[File:25x-NBOMe.png|301px|thumbnail|The general structure for a 25x-NBOMe compound]]
[[File:25x-NBOMe.svg|301px|thumbnail|The general structure for a 25x-NBOMe compound]]
'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.  
'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.  


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! scope="col" | '''Structure'''
! scope="col" | '''Structure'''
|-
|-
| [[25B-NBOMe]] || Br || [[File:25b-NBOMe.png|200px]]
| [[25B-NBOMe]] || Br || [[File:25B-NBOMe.svg|200px]]
|-
|-
| [[25C-NBOMe]] || Cl || [[File:25c-NBOMe.png|200px]]
| [[25C-NBOMe]] || Cl || [[File:25C-NBOMe.svg|200px]]
|-
|-
| [[25D-NBOMe]] || CH<sub>3</sub> || [[File:25D-NBOMe.png|200px]]
| [[25D-NBOMe]] || CH<sub>3</sub> || [[File:25D-NBOMe.svg|200px]]
|-
|-
| [[25I-NBOMe]] || I || [[File:25i-NBOMe.png|200px]]
| [[25I-NBOMe]] || I || [[File:25I-NBOMe.svg|200px]]
|-
|-
| [[25N-NBOMe]] || NO<sub>2</sub> || [[File:25n-NBOMe.png|200px]]
| [[25N-NBOMe]] || NO<sub>2</sub> || [[File:25N-NBOMe.svg|200px]]
|-
| 25iP-NBOMe || CH(CH<sub>3</sub>)<sub>2</sub> || [[File:25iP-NBOMe.svg|200px]]
|-
|-
|}
|}


==Toxicity and harm potential==
==Toxicity and harm potential==
The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]]. This helps to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal.
{{toxicity}}
===Tolerance and addiction potential===
Members of the 25x-NBOMe series are [[Addiction potential::not habit-forming]] and the desire to use them can actually decrease with use. They are thought to be most often self-regulating.  


==Legality==
Tolerance to the effects of any member of the 25x-NBOMe series is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back to baseline (in the absence of further consumption). Members of the 25x-NBOMe series present cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of any member of the 25x-NBOMe series all psychedelics will have a reduced effect.
 
===Overdose===
{{NBOMeOD}}
 
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/NBOMe}}
 
====[[Serotonin syndrome]] risk====
{{DangerousInteractions/SerotoninSyndrome}}
 
==Legal status==
{{legalStub}}
*'''Austria:''' The 25x-NBOMe family is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).{{citation needed}}
*'''Poland:''' The 25x-NBOMe family is controlled by Group I-P in "Act of 29 July 2005 on preventing drug addictions" (Ustawa z dnia 29 lipca 2005 o przeciwdziałaniu narkomanii).{{citation needed}}
*'''United States:''' In the US, some of the 25x-NBOMe chemicals are listed as Schedule I substances and others may be considered analogues under the Federal Analogue Act.{{citation needed}}
*'''United States:''' In the US, some of the 25x-NBOMe chemicals are listed as Schedule I substances and others may be considered analogues under the Federal Analogue Act.{{citation needed}}
*'''United Kingdom:''' The majority of synthesised 25x-NBOMe substances are Class A drugs in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.<ref>United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made</ref> Any compounds not covered by the clause are illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>


==See also==
==See also==
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*[[2C-x]]
*[[2C-x]]
*[[DOx]]
*[[DOx]]
==External links==
*[https://en.wikipedia.org/wiki/25-NB 25-NB (Wikipedia)]
*[https://erowid.org/chemicals/nbome/nbome.shtml NBOMe Series (Erowid Vault)]
==Literature==
==Literature==
*Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H., & Kristensen, J. L. (2014). Synthesis and structure–activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chemical Neuroscience, 5(3), 243-249. https://doi.org/10.1021/cn400216u
*Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H., & Kristensen, J. L. (2014). Synthesis and structure–activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chemical Neuroscience, 5(3), 243-249. https://doi.org/10.1021/cn400216u
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==References==
==References==
<references />
<references />
[[Category:Chemical class]]
[[Category:25x-NBOMe|*]]