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| ''[[3-MeO-PCE/Summary|Summary sheet: 3-MeO-PCE]]''
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'''3-Methoxyeticyclidine''' (abbreviated '''3-MeO-PCE'''; also known as '''Methoxieticyclidine''') is a synthetic [[hallucinogenic]] [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class.


Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]]/[[PCE]], [[MXE]] and [[O-PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative substances | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]. Because of this, it is highly recommended to use [[responsible substance use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.
'''3-Methoxyeticyclidine''' (also known as '''Methoxieticyclidine''' and '''3-MeO-PCE''') is a novel [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class that produces [[dissociative]] and [[hallucinogenic]] effects when [[Routes of administration|administered]]. It is a structural analog of [[PCE]].  


3-MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. | https://www.ncbi.nlm.nih.gov/pubmed/26360516</ref><ref>From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices
3-MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>{{cite journal | vauthors=((Wallach, J.)), ((Colestock, T.)), ((Cicali, B.)), ((Elliott, S. P.)), ((Kavanagh, P. V.)), ((Adejare, A.)), ((Dempster, N. M.)), ((Brandt, S. D.)) | journal=Drug Testing and Analysis | title=Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines | volume=8 | issue=8 | pages=801–815 | date= August 2016 | issn=1942-7611 | doi=10.1002/dta.1861}}</ref><ref>{{cite journal | vauthors=((De Paoli, G.)), ((Brandt, S. D.)), ((Wallach, J.)), ((Archer, R. P.)), ((Pounder, D. J.)) | journal=Journal of Analytical Toxicology | title=From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices | volume=37 | issue=5 | pages=277–283 | date=1 June 2013 | url=https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkt023 | issn=0146-4760 | doi=10.1093/jat/bkt023}}</ref><ref>{{Citation | title=nsddb.eu | url=http://nsddb.eu/substance/296/}}</ref>  
| http://jat.oxfordjournals.org/content/37/5/277.full</ref><ref>http://nsddb.eu/substance/296/</ref>  
 
Very little data exists about the pharmacological properties, metabolism, and toxicity of 3-MeO-PCE, and it has a very brief history of human usage. It is strongly recommended that one use harm reduction practices if using this substance.


==Chemistry==
==Chemistry==
3-MeO-PCE, or N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an [[arylcyclohexylamine]] drug. Ayrlcyclohexylamine substances are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-MeO-PCE contains a phenyl ring with a methoxy (CH<sub>3</sub>-O-) substituent at R<sub>3</sub> bonded to a cyclohexane ring. Bound to the same carbon (R<sub>1</sub>) of the cyclohexanone ring is an amino ethyl chain -NCH<sub>2</sub>CH<sub>3</sub>. 3-MeO-PCE, like [[MXE]], contains an amino ethyl chain rather than the amino methyl chain found in [[DCK]] and [[ketamine]]. 3-MeO-PCE is analogous to [[MXE]], but lacks an R<sub>2</sub> substituted ketone. It is also homologous to [[3-MeO-PCP]] but lacks the additional carbons to complete a piperidine ring.
3-MeO-PCE, or N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an [[arylcyclohexylamine]] drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-MeO-PCE contains a phenyl ring with a methoxy (CH<sub>3</sub>-O-) substituent at R<sub>3</sub> bonded to a cyclohexane ring. Bound to the same carbon (R<sub>1</sub>) of the cyclohexanone ring is an amino ethyl chain -NCH<sub>2</sub>CH<sub>3</sub>. 3-MeO-PCE, like [[MXE]], contains an amino ethyl chain rather than the amino methyl chain found in [[DCK]] and [[ketamine]]. 3-MeO-PCE is analogous to [[MXE]], but lacks an R<sub>2</sub> substituted ketone. It is also homologous to [[3-MeO-PCP]] but lacks the additional carbons to complete a piperidine ring.


==Pharmacology==
==Pharmacology==
{{Main|NMDA receptor antagonist}}
{{Further|NMDA receptor antagonist}}
3-MeO-PCE acts principally as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”
3-MeO-PCE acts principally as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”


3-MeO-PCE has Ki values of 61 nM for the NMDA receptor, 115 nM for the [[serotonin]] transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor.<ref>https://www.ncbi.nlm.nih.gov/pubmed/23527166 | https://www.ncbi.nlm.nih.gov/pubmed/23527166</ref>
3-MeO-PCE has Ki values of 61 nM for the NMDA receptor, 743 nM for the dopamine transporter, 2097 nM for the histamine H2 receptor, 964 nM for the Alpha-2A adrenergic receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor and 525 nM for the σ2 receptor. <ref>{{cite journal | vauthors=((Roth, B. L.)), ((Gibbons, S.)), ((Arunotayanun, W.)), ((Huang, X.-P.)), ((Setola, V.)), ((Treble, R.)), ((Iversen, L.)) | journal=PLOS ONE | title=Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor | volume=13 | issue=3 | pages=e0194984 | date=22 March 2018 | url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194984 | issn=1932-6203 | doi=10.1371/journal.pone.0194984}}</ref>


==Subjective effects==
==Subjective effects==
3-MeO-PCE can be said to share extremely similar properties to that of [[3-MeO-PCP]] but with a considerably higher risk of inducing serious [[psychosis]], [[delusions]], and [[mania]] which may make it dangerous to use regardless of the setting.
3-MeO-PCE can be said to share extremely similar properties to that of [[3-MeO-PCP]] but with a potentially higher risk of inducing states of [[mania]], [[delusions]] and potential [[psychosis]] due to the greater degree of euphoric [[stimulation]] and the [[compulsive redosing]] it can lead to. However, the effects are reported to largely converge with those of [[3-MeO-PCP]] after a certain dose-point, when the [[dissociative|dissociating]] effects come to dominate.


It is significantly more stimulating and less sedating than other [[dissociative]]s such as [[ketamine]] or [[MXE]]. It's far more comfortable than [[O-PCE]], [[MXP]], [[diphenidine]] and other [[noradrenaline]] [[reuptake-inhibit]]ing dissociative compounds which suggests that it may have a higher affinity for [[dopamine]] or [[serotonin]].
It is also often reported to be significantly more stimulating and less sedating than other [[dissociatives]] such as [[ketamine]] or [[MXE]] while more comfortable than [[O-PCE]], [[MXP]], [[diphenidine]] and other [[noradrenaline]] [[reuptake inhibitor|reuptake inhibiting]] dissociative compounds which suggests that it may have a higher affinity for [[dopamine]] or [[serotonin]].{{citation needed}}


{{Preamble/SubjectiveEffects}}
{{Preamble/SubjectiveEffects}}
===Physical effects===
{{effects/base
====Enhancements====
 
*'''[[Effect::Bodily control enhancement]]''' and '''[[Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control
|{{effects/physical|
*'''[[Effect::Stimulation]]''' - This substance is extremely stimulating in comparison to other dissociatives such as [[ketamine]], [[MXE]], or [[DCK]]. The stimulation it presents is clean and comfortable in a manner which is far closer to that of [[3-MeO-PCP]] than that of [[O-PCE]].


====Suppressions====
*'''[[Effect::Stimulation]]''' - This drug is extremely stimulating in comparison to other dissociatives such as [[ketamine]], [[MXE]], or [[DCK]]. The stimulation it presents is clean and comfortable in a manner which is far closer to that of [[3-MeO-PCP]] than that of [[O-PCE]].
*'''[[Effect::Perception of bodily lightness]]'''
*'''[[Effect::Restless legs]]'''
*'''[[Effect::Spontaneous physical sensations]]''' - The  body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, euphoric general activation of nerve endings across the body. This feels halfway between the same sensations induced by [[3-MeO-PCP]] and [[O-PCE]] and disappears at higher doses due to the disconnecting and anesthetic effects it produces.
*'''[[Effect::Physical euphoria]]''' - At lower to moderate dosages, the sensation itself can be described as feelings of physical comfort, warmth and euphoria which spreads throughout the body. However, at heavier dosages, this sensation becomes neutral or potentially uncomfortable in terms of its enjoyability.
*'''[[Effect::Bodily control enhancement]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards losses in gross and fine motor control.
*'''[[Effect::Tactile enhancement]]''' & '''[[Effect::Tactile suppression]]''' - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and [[pain relief|anesthesia]].
*'''[[Effect::Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards losses in gross and fine motor control.
*'''[[Effect::Changes in felt gravity]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Appetite suppression]]'''
*'''[[Effect::Nausea suppression]]'''
*'''[[Effect::Nausea suppression]]'''
*'''[[Effect::Bodily control enhancement]]''' and '''[[Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control
*'''[[Effect::Perception of decreased weight]]'''
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Pain relief]]'''
*'''[[Effect::Respiratory depression]]''' - This effect can be present at heavier dosage levels.{{citation needed}}
*'''[[Effect::Increased blood pressure]]''' - This effect is typically present at the higher doses.{{citation needed}}
 
*'''[[Effect::Increased heart rate]]''' - An uncomfortably increased heart rate may become present at heavier dosages but is not noticeable at low to moderate dosages. It tends to become more prominent towards the [[offset]] of the trip. This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[ketamine]].
====Novel effects====
*'''[[Effect::Respiratory depression]]''' - This effect has been reported to be present at heavier dosage levels.{{citation needed}}
*'''[[Effect::Physical autonomy]]'''
*'''[[Effect::Physical autonomy]]'''
*'''[[Effect::Physical euphoria]]''' - At lower to moderate dosages, the sensation itself can be described as feelings of physical comfort, warmth and euphoria which spreads throughout the body. However, at heavier dosages, this sensation becomes neutral or potentially uncomfortable in terms of its enjoyability.
*'''[[Effect::Changes in gravity]]'''
*'''[[Effect::Olfactory hallucinations]]
*'''[[Effect::Olfactory hallucinations]]
*'''[[Effect::Optical sliding]]'''
*'''[[Effect::Optical sliding]]'''
*'''[[Effect::Spatial disorientation]]'''
*'''[[Effect::Spatial disorientation]]'''
 
*'''[[Effect::Dizziness]]'''
===Uncomfortable physical side effects===
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Abnormal heartbeat]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dehydration]]'''
*'''[[Effect::Dizziness]]'''
*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Difficulty urinating]]'''
*'''[[Effect::Increased blood pressure]]''' - This effect is typically present at the higher doses.{{citation needed}}
*'''[[Effect::Increased heart rate]]''' - An uncomfortably increased heart rate may become present at heavier dosages but is not noticeable at low to moderate dosages. It tends to become more prominent towards the [[offset]] of the trip. This effect has been reported as being more pronounced than other dissociatives, such as [[DCK]] or [[ketamine]].
*'''[[Effect::Increased perspiration]]'''
*'''[[Effect::Nausea]]'''
*'''[[Effect::Restless leg syndrome]]'''
*'''[[Effect::Seizure]]'''
*'''[[Effect::Seizure]]'''
*'''[[Effect::Temperature regulation suppression]]'''


===Tactile effects===
}}
*'''[[Effect::Spontaneous tactile sensations]]''' - The  body high of this compound can be described in terms of its style variations as a motionless, constant, sharp, all-encompassing, euphoric general activation of nerve endings across the body. This feels halfway between the same sensations induced by [[3-MeO-PCP]] and [[O-PCE]].
{{effects/disconnective|
*'''[[Effect::Tactile enhancement]]''' and '''[[Effect::Tactile suppression]]''' - At lower dosages, this compound tends to induce tactile enhancements. At higher dosages, this enhancement shifts towards tactile suppressions and [[pain relief|anesthesia]].
*'''[[Effect::Tactile disconnection]]'''
*'''[[Effect::Tactile disconnection]]'''
*'''[[Effect::Visual disconnection]]''' - This eventually results in 3-MeO-PCE's equivalent of the notorious "[https://en.wikipedia.org/wiki/K-hole k-hole]" or, more specifically, ''[[Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Visual disconnection#Structures|structures]]''.
*'''[[Effect::Consciousness disconnection]]'''
}}
{{effects/auditory|
*'''[[Effect::Auditory suppression|Suppression]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
}}
{{effects/multisensory|
*'''[[Effect::Synaesthesia]]'''
}}
{{effects/transpersonal|
*'''[[Effect::Unity and interconnectedness]]'''
}}
|{{effects/cognitive|


===Cognitive effects===
*'''[[Effect::Amnesia]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Anxiety suppression]]'''
*'''[[Effect::Consciousness disconnection]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Compulsive redosing]]''' - This effect is more prominent based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance entering and leaving the bloodstream.
*'''[[Effect::Mania]]''' - This effect is reportedly more common on 3-MeO-PCE than most other dissociatives. It typically occurs during the offset of the trip, but can also occur during the onset and come up as well.
*'''[[Effect::Cognitive euphoria]]'''
*'''[[Effect::Depersonalization]]'''
*'''[[Effect::Derealization]]'''
*'''[[Effect::Delusion]]''' - Like psychosis, this effect is reportedly more common on 3-MeO-PCE than most other dissociatives.
**'''[[Effect::Delusions#Delusions of sobriety|Delusions of sobriety]]'''
**'''[[Effect::Compulsive redosing]]''' - This effect is more prominent based on the route of administration used. For example, it is especially present when smoked or vaporized, due to the relative abruptness of the substance entering and leaving the bloodstream.
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Creativity enhancement]]'''
*'''[[Effect::Déjà vu]]'''
*'''[[Effect::Déjà vu]]'''
*'''[[Effect::Mania]]''' - This effect is reportedly more common on 3-MeO-PCE than most other dissociatives. It typically occurs during the offset of the trip, but can also occur during the onset and come up as well.
*'''[[Effect::Depersonalization]]'''
*'''[[Effect::Derealization]]'''
*'''[[Effect::Disinhibition]]'''
*'''[[Effect::Psychosis]]''' - This effect has been reported to be more common on 3-MeO-PCE than most other dissociatives, such as [[MXE]] or [[Ketamine]]. It typically occurs during the [[offset]] of the trip, but can also occur during the [[onset]] and [[comeup]] as well.
*'''[[Effect::Delusions]]''' - Like psychosis, this effect is reportedly more common on 3-MeO-PCE than most other dissociatives.
*'''[[Effect::Dream potentiation]]'''
*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Cognitive euphoria|Euphoria]]'''
*'''[[Effect::Memory suppression]]'''  
*'''[[Effect::Memory suppression]]'''  
**'''[[Effect::Ego death]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Amnesia]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Information processing suppression]]'''
*'''[[Effect::Analysis suppression]]'''
*'''[[Effect::Introspection]]'''
*'''[[Effect::Introspection]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Thought deceleration]]'''
*'''[[Effect::Psychosis]]''' - This effect has been reported to be more common on 3-MeO-PCE than most other dissociatives, such as [[MXE]] or [[Ketamine]]. It typically occurs during the [[offset]] of the trip, but can also occur during the [[onset]] and [[come up]] as well.
}}
{{effects/visual|


===Visual effects===
====Enhancements====
====Enhancements====
*'''[[Effect::Acuity enhancement]]''' - This effect has been reported as being especially present at low dosages.
*'''[[Effect::Acuity enhancement]]''' - This effect has been reported as being especially present at low dosages.
*'''[[Effect::Colour enhancement]]'''
*'''[[Effect::Colour enhancement]]'''
====Suppressions====
====Suppressions====
*'''[[Effect::Visual disconnection]]''' - This eventually results in 3-MeO-PCE's equivalent of the famous "[https://en.wikipedia.org/wiki/K-hole k-hole]" or more specifically, ''[[Effect::Visual disconnection#Holes, spaces and voids|holes, spaces and voids]]'' alongside of ''[[Effect::Visual disconnection#Structures|structures]]''. However although it is possible to achieve, this may be significantly more dangerous than other dissociatives due to the accompanying psychosis.
*'''[[Effect::Double vision]]'''
*'''[[Effect::Double vision]]'''
*'''[[Effect::Frame rate suppression]]'''
*'''[[Effect::Frame rate suppression]]'''
Line 112: Line 123:


====Hallucinatory states====
====Hallucinatory states====
*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
*'''[[Effect::Internal hallucination]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::perspective hallucinations]]'' and ''[[effect::scenarios and plots]]'')


===Auditory effects===
}}
*'''[[Effect::Auditory suppression|Suppression]]''' and '''[[Effect::Auditory enhancement|enhancement]]'''
}}
*'''[[Effect::Auditory distortion|Distortions]]'''
===Experience reports===
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
Anecdotal reports which describe the effects of this compound within our [[experience index]] include:
{{#ask: [[Category:3-MeO-PCE]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:


===Experience reports===
*[https://erowid.org/experiences/subs/exp_3MEOPCE_.shtml Erowid Experience Vaults: 3-MeO-PCE]
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
* [https://erowid.org/experiences/subs/exp_3MEOPCE_.shtml Erowid Experience Vaults: 3-MeO-PCE]


==Toxicity and harm potential==
==Toxicity and harm potential==
{{Main|Research chemicals#Toxicity and harm potential}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 3-MeO-PCE use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because 3-MeO-PCE has very little history of human usage.  
The toxicity and long-term health effects of recreational 3-MeO-PCE use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dosage is unknown]]. This is because 3-MeO-PCE has very little history of human usage.  
===Psychosis===
===Psychosis===
3-MeO-PCE has been reported to cause [[psychosis]], [[delusions]], and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug.
3-MeO-PCE has been reported to cause [[psychosis]], [[delusions]], and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the substance.
 
It is strongly recommended that one use extreme caution and [[responsible drug use|harm reduction]] practices when using this substance.


It is strongly recommended that one use extreme caution and [[responsible substance use|harm reduction]] practices when using this substance.
*Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
*Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.  
*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.  
*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the substance's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCE (TripSit) | https://wiki.tripsit.me/wiki/3-MeO-PCE</ref>
*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-MeO-PCE (TripSit) | https://wiki.tripsit.me/wiki/3-MeO-PCE</ref>  
*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.  


Due to the risk of psychosis, it is not recommended to combine this substance with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulants]], [[psychedelics]], or other [[dissociatives]] like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.


It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this substance.
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the accurate administration of the intended dose.


===Tolerance and addiction potential===
===Tolerance and addiction potential===
The chronic use of 3-MeO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociative]]s, 3-MeO-PCE has been reported to be more habit-forming than [[MXE]], [[diphenidine]], [[ephenidine]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
The chronic use of 3-MeO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociatives]], 3-MeO-PCE has been reported to be more habit-forming than [[MXE]], [[diphenidine]], [[ephenidine]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.


Tolerance to many of the effects of 3-MeO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-MeO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the use of 3-MeO-PCE, all [[dissociative]]s will have a reduced effect.
Tolerance to many of the effects of 3-MeO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-MeO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociatives]]]], meaning that after the use of 3-MeO-PCE, all [[dissociatives]] will have a reduced effect.


===Urinary tract effects===
===Urinary tract effects===
Regarding its long-term health effects when used repeatedly and over excessive periods, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine, so significantly less of substance needs to be consumed. Symptoms of ketamine-induced cystitis can become severe and can be described as:
Regarding its long-term health effects when used repeatedly and over excessive periods, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine, so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become severe and can be described as:


*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.  
*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.
*'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
*'''Urinary urgency''' - This can be described as a sudden, compelling need to urinate.
*'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
*'''Urinary pressure''' - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
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===Dangerous interactions===
===Dangerous interactions===
{{DangerousInteractions/Intro}}
{{DangerousInteractions/Intro}}
*'''[[Psychedelics]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.
 
*'''[[Stimulants]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociative]]s.
*'''[[Psychedelics]]''' - This combination is not advised because 3-MeO-PCE has been reported to cause extreme psychological disturbances such as [[psychosis]] and mania at a significantly higher rate than other [[dissociatives]].
{{DangerousInteractions/Dissos}}
{{DangerousInteractions/Dissos}}


==Legal issues==
==Legal status==
{{legalStub}}
{{legalStub}}
*'''United Kingdom''' - It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
 
*'''Czech Republic:'''  6-APB is a Schedule I (List 4) substance. It may be used for research and restricted therapeutic purposes. (§ 1, d), 1. of Nařízení vlády č. 463/2013 Sb.) <ref> https://www.zakonyprolidi.cz/cs/2013-463?text=o+seznamech+n%C3%A1vykov%C3%BDch </ref>
*'''Germany:''' 3-MeO-PCE is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref> as of July 18, 2019.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl119s1083.pdf|title=Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes|publisher=Bundesanzeiger Verlag|work=Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27|pages=1083-1094|publication-date=July 17, 2019|access-date=January 1, 2020|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]|access-date=December 10, 2019|language=de}}</ref>
*'''Switzerland:''' 3-MeO-PCE is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''Turkey:''' 3-MeO-PCE is a classed as drug and is illegal to possess, produce, supply, or import.<ref name="Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742">{{Citation | title=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü | url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm}}</ref> <ref name="List of illegal substances for law"> https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf</ref>
*'''United Kingdom''' - 3-MeO-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. As an N-alkyl derivative of 1-phenylcyclohexylamine substituted in the phenyl ring with an alkoxy substituent, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2013 | url=https://www.legislation.gov.uk/uksi/2013/239/introduction/made}}</ref>
 
==See also==
==See also==
*[[Responsible use]]
*[[Responsible use]]
**[[Volumetric dosing]]
*[[Research chemical]]
*[[Research chemical]]
*[[Dissociatives]]
*[[Dissociatives]]
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==External links==
==External links==
*[https://en.wikipedia.org/wiki/3-MeO-PCE 3-MeO-PCE (Wikipedia)]
*[https://en.wikipedia.org/wiki/3-MeO-PCE 3-MeO-PCE (Wikipedia)]
*[https://isomerdesign.com/PiHKAL/explore.php?id=966 3-MeO-PCE (Isomer Design)]
*[http://www.bluelight.org/vb/threads/532702-The-Big-amp-Dandy-3-MeO-PCE-Thread 3-MeO-PCE (Bluelight)]
*[http://www.bluelight.org/vb/threads/532702-The-Big-amp-Dandy-3-MeO-PCE-Thread 3-MeO-PCE (Bluelight)]
*[http://drugs.tripsit.me/3-meo-pcp 3-MeO-PCE (Tripsit)]
*[https://web.archive.org/web/20170111011440*/https://www.vice.com/en_us/article/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist (VICE)]
*[https://web.archive.org/web/20170111011440*/https://www.vice.com/en_us/article/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist (VICE)]


==Literature==
==Literature==
* Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620
 
*Morris, H., & Wallach, J. (2014). From PCP to MXE: A comprehensive review of the non-medical use of dissociative drugs. Drug Testing and Analysis, 6(7–8), 614–632. https://doi.org/10.1002/dta.1620


==References==
==References==
<references/>
<references />
[[Category:Psychoactive substance]]
 
[[Category:Research chemical]]
[[Category:Psychoactive substance]]a
[[Category:Arylcyclohexylamine]]
[[Category:Arylcyclohexylamine]]
[[Category:Piperidine]]
[[Category:Dissociative]]
[[Category:Dissociative]]
[[Category:Research chemical]]


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