2C-H: Difference between revisions

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~~| ''[[2C-H/Summary|Summary sheet: 2C-H]]''~~

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'''2C-H''' ('''2,5-Dimethoxyphenethylamine''') is a lesser-known [[substituted phenethylamine]] that is the traditional precursor to [[2C-B]], [[2C-C]] and [[2C-I]]. It was first synthesized in 1932 by Johannes S. Buck and was later studied in the 1970s by [[Alexander Shulgin]], who published his findings in his book [[PiHKAL]].

Shulgin lists both the dosage and duration as unknown, as 2C-H is likely easily broken down by ~~the~~ MAO ~~enzyme~~ in the liver and is thus ~~considered~~ probably inactive. However, there ~~are~~ some anecdotal reports ~~online suggesting~~ that it may be active when [[~~sublingual~~]]ly.<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> ~~When combined~~ with an [[MAOI]], it ~~may be~~ [[~~oral~~]]~~ly active~~.

'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class. 2C-H belongs to the [[2C-x]] family of substituted phenethylamines. However, it does not have any significant psychedelic properties and is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.

2C-H was first synthesized in 1932 by Johannes S. Buck.<ref>{{cite journal|last1=Buck|first1=J. S.|year=1932|title=Hydroxy- And Dihydroxyphenylethylmethylamines And Their Ethers|journal=Journal of the American Chemical Society|volume=54|issue=9|pages=3661-3665|doi=10.1021/ja01348a024|issn=0002-7863|eissn=1520-5126|oclc=01226990}}</ref> Its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].

In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>{{cite web|title=So Happy, Very Happy 2C-H|author="PandaDoom"|publisher=Erowid|url=https://erowid.org/experiences/exp.php?ID=80334|date=August 3, 2009|id=exp80334|work=Experience Vaults}}</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. It is highly advised to use [[harm reduction practices]] when using this substance.

==Chemistry==

2C-H or 2,5-dimethoxyphenethylamine is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-H contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a hydrogen atom attached to carbon R4 of the phenyl ring. 2C-H belongs to the [[2C-x|2C]] ~~family~~ of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the ~~[[2C-x|~~2C family]], including [[2C-B]], [[2C-C]], [[2C-I]], and [[2C-N]].

2C-H, or 2,5-dimethoxyphenethylamine, is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-H contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a hydrogen atom attached to carbon R4 of the phenyl ring. 2C-H belongs to the [[2C-x|2C family]] of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the 2C family, including [[2C-B]], [[2C-C]], [[2C-I]], and [[2C-N]].

==Pharmacology==

There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects.<ref> [[Alexander ~~Shlulgin~~|Shulgin~~, Alexander]]; [[~~Ann Shulgin~~]] (September~~ 1991~~). [~~https://~~www.~~erowid.org/library/books_online/pihkal/~~pihkal023~~.shtml ~~PiHKAL: A Chemical Love Story~~.~~] Berkeley, California: Transform Press. ISBN 0~~-~~9630096-0-5. OCLC 25627628.~~</ref> Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards [[Serotonin#The_5-HT_system|5-HT2C]] and [[Serotonin#The_5-HT_system|5-HT2A]] [[receptor]]s in rats.<ref>2C-~~H BioAssay~~ Results (PubChem) | https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=~~BioAssay~~-Results</ref>

There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal032.shtml|chapter=#32. 2C-H}}</ref> Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards [[Serotonin#The_5-HT_system|5-HT2C]] and [[Serotonin#The_5-HT_system|5-HT2A]] [[receptor]]s in rats.<ref>{{cite web|title=2,5-Dimethoxyphenethylamine (compound): Biological Test Results|publisher=PubChem|url=https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=Biological-Test-Results|access-date=October 11, 2020}}</ref> 2C-H has been shown to inhibit MAO-B activity by over 50% in experiments.<ref name="WagmannBrandt2019">{{cite journal|last1=Wagmann|first1=Lea|last2=Brandt|first2=Simon D.|last3=Stratford|first3=Alexander|last4=Maurer|first4=Hans H.|last5=Meyer|first5=Markus R.|title=Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases|pmid=30188017|journal=Drug Testing and Analysis|volume=11|issue=2|year=2019|pages=318–324|issn=1942-7603|doi=10.1002/dta.2494|eissn=1942-7611|oclc=231680670}}</ref>

==Subjective effects==

The effects of 2C-H are reportedly inactive. Taking higher dosages could produce primarily stimulating in addition to empathogenic or hallucinogenic effects, in a fashion similar to those of its predecessor substance, [[phenethylamine]].

{{effects/base

|{{effects/physical|

*'''[[Effect::Stimulation]]'''

*'''[[Effect::Spontaneous physical sensations]]'''

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Temperature regulation suppression]]'''

*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Increased perspiration]]'''

}}

{{effects/visual|

*'''[[Effect::Color enhancement]]''' - This effect is debated.

}}

|{{effects/cognitive|

*'''[[Effect::Cognitive euphoria]]'''

*'''[[Effect::Increased sense of humor]]'''

*'''[[Effect::Paranoia]]'''

*'''[[Effect::Increased music appreciation]]'''

}}

===Experience reports===

There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:

* [https://erowid.org/experiences/~~exp~~.~~php?ID=80334~~ Erowid Experience Vaults: 2C-H]

*[https://www.erowid.org/experiences/subs/exp_2CH.shtml Erowid Experience Vaults: 2C-H]

==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-H is a [[research chemical]] with very little history of human usage. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-H is a [[research chemical]] with very little history of human usage.

Anecdotal reports from those who have tried 2C-H suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.duckduckgo.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this ~~drug~~.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance so as to ensure the accurate administration of the intended dose.

===Tolerance and addiction potential===

Although no formal studies have been conducted, it is not unreasonable to assume that as is the case with psychedelics in general, 2C-H is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use. However, it's stimulating properties do provide a possible risk of addiction which would be associated with other [[stimulants]].

==Legal ~~issues~~==

Tolerance to the effects of 2C-H is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3-5 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7-10 days]] to be back at baseline (in the absence of further consumption). 2C-H may present cross-tolerance, although unlikely, with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-H all psychedelics will have a reduced effect. It may also produce tolerance to stimulants as well.

*'''Canada:''' As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.<ref>http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php</ref>

*'''United States:''' As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.<ref>https://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0104.htm</ref>

===Dangerous interactions===

*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>~~Psychoactive Substances Act 2016 (Legislation.gov.uk)~~ | http://www.~~legislation~~.~~gov.uk~~/~~ukpga~~/~~2016~~/2/~~contents~~/~~enacted~~</ref>

==Legal status==

*'''Austria''': 2C-H is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). In its Schedule II, the further specifying NPSV (Neue-Psychoaktive-Substanzen-Verordnung Österreich) explicitly bans all substituted phenetylamines.<ref>{{cite web|url=https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007642|title=Bundesrecht konsolidiert: Gesamte Rechtsvorschrift für Neue-Psychoaktive-Substanzen-Verordnung|date=June 26, 2019|language=de|access-date=January 10, 2021}}</ref>

*'''Canada''': As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.<ref>{{cite journal|url=http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php|title=Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)|id=SOR/2016-72|issn=0045-4206|work=Canada Gazette Part II|volume=150|issue=9|publication-date=May 4, 2016|date=April 15, 2016|}}</ref>

*'''Germany''': 2C-H is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of November 26, 2016.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|pages=2615-2622|issn=0341-1095|oclc=1004462279|publisher=Bundesanzeiger Verlag|date=November 21, 2016|publication-date=November 25, 2016|language=de|work=Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>

*'''Sweden''': 2C-H is classified as a hazardous substance.

*'''Switzerland''': 2C-H can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''Turkey:''' 2C-H is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr}}</ref><ref>{{cite web|title=Kararnamenin Eki: Liste|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr|id=2013/5742|work=Resmî Gazete, Sayı: 28893}}</ref>

*'''United Kingdom''': 2C-H is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>

*'''United States''': As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.<ref>{{cite magazine|url=https://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0104.htm|title=Establishment of Drug Codes for 26 Substances|work=Federal Register|volume=78|issue=3|publisher=Diversion Control Devision|pages=664-666|id=FR Doc No: 2012-31698|publication-date=January 4, 2013}}</ref><ref>{{cite web|url=http://www.govtrack.us/congress/bills/112/s3187/text|title=S. 3187 (112th): Food and Drug Administration Safety and Innovation Act|date=June 27, 2012|access-date=October 10, 2020|publisher=GovTrack}}</ref>

==See also==

*[[Responsible use]]

*[[Substituted phenethylamine]]

*[[~~Stimulant~~]]

*[[2C-x]]

*[[2C-B]]

*[[2,5-DMA]]

==External links==

*[https://en.wikipedia.org/wiki/2C-H 2C-H (Wikipedia)]

*[https://~~erowid~~.~~org~~/~~library~~/~~books_online/pihkal/pihkal032~~.~~shtml~~ 2C-H (PiHKAL/~~Erowid~~)]

*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=32 2C-H (PiHKAL / Isomer Design)]

*[http://www.bluelight.org/vb/threads/446462-The-Main-2C-H-Thread 2C-H (Bluelight)]

===Discussion===

*[http://www.bluelight.org/vb/threads/446462-The-Main-2C-H-Thread The Main 2C-H Thread (Bluelight)]

==References==

[[Category:~~Phenethylamine~~]]

[[Category:Psychoactive substance]]

[[Category:Psychedelic]]

[[Category:Stimulant]]

[[Category:2C-x]]

[[Category:Research chemical]]

@@ Line 1: / Line 1: @@
-{{proofread}}
+{{SummarySheet}}
 {{SubstanceBox/2C-H}}
-{|
-|-
-|-
-| ''[[2C-H/Summary|Summary sheet: 2C-H]]''
-|}
-'''2C-H''' ('''2,5-Dimethoxyphenethylamine''') is a lesser-known [[substituted phenethylamine]] that is the traditional precursor to [[2C-B]], [[2C-C]] and [[2C-I]]. It was first synthesized in 1932 by Johannes S. Buck and was later studied in the 1970s by [[Alexander Shulgin]], who published his findings in his book [[PiHKAL]].
-Shulgin lists both the dosage and duration as unknown, as 2C-H is likely easily broken down by the MAO enzyme in the liver and is thus considered probably inactive. However, there are some anecdotal reports online suggesting that it may be active when [[sublingual]]ly.<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> When combined with an [[MAOI]], it may be [[oral]]ly active.
+'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class. 2C-H belongs to the [[2C-x]] family of substituted phenethylamines. However, it does not have any significant psychedelic properties and is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.
+C-H was first synthesized in 1932 by Johannes S. Buck.<ref>{{cite journal|last1=Buck|first1=J. S.|year=1932|title=Hydroxy- And Dihydroxyphenylethylmethylamines And Their Ethers|journal=Journal of the American Chemical Society|volume=54|issue=9|pages=3661-3665|doi=10.1021/ja01348a024|issn=0002-7863|eissn=1520-5126|oclc=01226990}}</ref> Its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].
+In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>{{cite web|title=So Happy, Very Happy 2C-H|author="PandaDoom"|publisher=Erowid|url=https://erowid.org/experiences/exp.php?ID=80334|date=August 3, 2009|id=exp80334|work=Experience Vaults}}</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. It is highly advised to use [[harm reduction practices]] when using this substance.
 ==Chemistry==
-C-H or 2,5-dimethoxyphenethylamine is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. 2C-H contains methoxy functional groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> as well as a hydrogen atom attached to carbon R<sub>4</sub> of the phenyl ring. 2C-H belongs to the [[2C-x|2C]] family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the [[2C-x|2C family]], including [[2C-B]], [[2C-C]], [[2C-I]], and [[2C-N]].
+C-H, or 2,5-dimethoxyphenethylamine, is a substituted [[phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. 2C-H contains methoxy functional groups CH<sub>3</sub>O- attached to carbons R<sub>2</sub> and R<sub>5</sub> as well as a hydrogen atom attached to carbon R<sub>4</sub> of the phenyl ring. 2C-H belongs to the [[2C-x|2C family]] of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring, and is also their simplest member. It is commonly used as a precursor to other compounds of the 2C family, including [[2C-B]], [[2C-C]], [[2C-I]], and [[2C-N]].
 ==Pharmacology==
-There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects.<ref> [[Alexander Shlulgin|Shulgin, Alexander]]; [[Ann Shulgin]] (September 1991). [https://www.erowid.org/library/books_online/pihkal/pihkal023.shtml PiHKAL: A Chemical Love Story.] Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.</ref> Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards [[Serotonin#The_5-HT_system|5-HT2C]] and [[Serotonin#The_5-HT_system|5-HT2A]] [[receptor]]s in rats.<ref>2C-H BioAssay Results (PubChem) | https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=BioAssay-Results</ref>
+There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal032.shtml|chapter=#32. 2C-H}}</ref>  Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards [[Serotonin#The_5-HT_system|5-HT2C]] and [[Serotonin#The_5-HT_system|5-HT2A]] [[receptor]]s in rats.<ref>{{cite web|title=2,5-Dimethoxyphenethylamine (compound): Biological Test Results|publisher=PubChem|url=https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=Biological-Test-Results|access-date=October 11, 2020}}</ref> 2C-H has been shown to inhibit MAO-B activity by over 50% in experiments.<ref name="WagmannBrandt2019">{{cite journal|last1=Wagmann|first1=Lea|last2=Brandt|first2=Simon D.|last3=Stratford|first3=Alexander|last4=Maurer|first4=Hans H.|last5=Meyer|first5=Markus R.|title=Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases|pmid=30188017|journal=Drug Testing and Analysis|volume=11|issue=2|year=2019|pages=318–324|issn=1942-7603|doi=10.1002/dta.2494|eissn=1942-7611|oclc=231680670}}</ref>
 ==Subjective effects==
 {{effectStub}}
+The effects of 2C-H are reportedly inactive. Taking higher dosages could produce primarily stimulating in addition to empathogenic or hallucinogenic effects, in a fashion similar to those of its predecessor substance, [[phenethylamine]].
+{{effects/base
+|{{effects/physical|
+*'''[[Effect::Stimulation]]'''
+*'''[[Effect::Spontaneous physical sensations]]'''
+*'''[[Effect::Increased heart rate]]'''
+*'''[[Effect::Temperature regulation suppression]]'''
+*'''[[Effect::Pupil dilation]]'''
+*'''[[Effect::Increased perspiration]]'''
+}}
+{{effects/visual|
+*'''[[Effect::Color enhancement]]''' - This effect is debated.
+}}
+|{{effects/cognitive|
+*'''[[Effect::Cognitive euphoria]]'''
+*'''[[Effect::Increased sense of humor]]'''
+*'''[[Effect::Paranoia]]'''
+*'''[[Effect::Increased music appreciation]]'''
+}}
+}}
 ===Experience reports===
 There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here:
-* [https://erowid.org/experiences/exp.php?ID=80334 Erowid Experience Vaults: 2C-H]
+*[https://www.erowid.org/experiences/subs/exp_2CH.shtml Erowid Experience Vaults: 2C-H]
 ==Toxicity and harm potential==
-{{toxicity}}
+{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-H is a [[research chemical]] with very little history of human usage. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
+The toxicity and long-term health effects of recreational 2C-H use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-H is a [[research chemical]] with very little history of human usage.
+Anecdotal reports from those who have tried 2C-H suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.duckduckgo.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance so as to ensure the accurate administration of the intended dose.
+===Tolerance and addiction potential===
+Although no formal studies have been conducted, it is not unreasonable to assume that as is the case with psychedelics in general, 2C-H is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use. However, it's stimulating properties do provide a possible risk of addiction which would be associated with other [[stimulants]].
-==Legal issues==
+Tolerance to the effects of 2C-H is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3-5 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7-10 days]] to be back at baseline (in the absence of further consumption). 2C-H may present cross-tolerance, although unlikely, with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-H all psychedelics will have a reduced effect. It may also produce tolerance to stimulants as well.
-*'''Canada:''' As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.<ref>http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php</ref>
-*'''United States:''' As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.<ref>https://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0104.htm</ref>
+===Dangerous interactions===
-*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
+{{DangerousInteractions/Intro}}
+{{DangerousInteractions/Psychedelics}}
+==Legal status==
+*'''Austria''': 2C-H is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich). In its Schedule II, the further specifying NPSV (Neue-Psychoaktive-Substanzen-Verordnung Österreich) explicitly bans all substituted phenetylamines.<ref>{{cite web|url=https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007642|title=Bundesrecht konsolidiert: Gesamte Rechtsvorschrift für Neue-Psychoaktive-Substanzen-Verordnung|date=June 26, 2019|language=de|access-date=January 10, 2021}}</ref>
+*'''Canada''': As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.<ref>{{cite journal|url=http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php|title=Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)|id=SOR/2016-72|issn=0045-4206|work=Canada Gazette Part II|volume=150|issue=9|publication-date=May 4, 2016|date=April 15, 2016|}}</ref>
+*'''Germany''': 2C-H is controlled under the NpSG<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> (''New Psychoactive Substances Act'') as of November 26, 2016.<ref>{{cite web|url=http://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|pages=2615-2622|issn=0341-1095|oclc=1004462279|publisher=Bundesanzeiger Verlag|date=November 21, 2016|publication-date=November 25, 2016|language=de|work=Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55}}</ref> Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref><ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__3.html|title=§ 3 NpSG|publisher=Bundesamt für Justiz [Federal Office of Justice]|access-date=December 10, 2019|language=de}}</ref> The legislator considers it possible that orders of 2C-H are punishable as an incitement to place it on the market.<ref>{{cite web|url=http://dip21.bundestag.de/dip21/btd/18/085/1808579.pdf|title=Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|page=20|date=May 30, 2016|id=Drucksache 18/8579|publisher=Deutscher Bundestag|language=de}}</ref>
+*'''Sweden''': 2C-H is classified as a hazardous substance.
+*'''Switzerland''': 2C-H can be considered a controlled substance as a defined derivative of Phenethylamine under Verzeichnis E point 130. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
+*'''Turkey:''' 2C-H is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2013/5742|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr}}</ref><ref>{{cite web|title=Kararnamenin Eki: Liste|url=https://resmigazete.gov.tr/eskiler/2014/01/20140125-3-1.pdf|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=January 25, 2014|date=December 16, 2013|language=tr|id=2013/5742|work=Resmî Gazete, Sayı: 28893}}</ref>
+*'''United Kingdom''': 2C-H is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
+*'''United States''': As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.<ref>{{cite magazine|url=https://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0104.htm|title=Establishment of Drug Codes for 26 Substances|work=Federal Register|volume=78|issue=3|publisher=Diversion Control Devision|pages=664-666|id=FR Doc No: 2012-31698|publication-date=January 4, 2013}}</ref><ref>{{cite web|url=http://www.govtrack.us/congress/bills/112/s3187/text|title=S. 3187 (112<sup>th</sup>): Food and Drug Administration Safety and Innovation Act|date=June 27, 2012|access-date=October 10, 2020|publisher=GovTrack}}</ref>
 ==See also==
 *[[Responsible use]]
 *[[Substituted phenethylamine]]
-*[[Stimulant]]
+*[[2C-x]]
-*[[2C-B]]
+*[[2,5-DMA]]
 ==External links==
 *[https://en.wikipedia.org/wiki/2C-H 2C-H (Wikipedia)]
-*[https://erowid.org/library/books_online/pihkal/pihkal032.shtml 2C-H (PiHKAL/Erowid)]
+*[https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=32 2C-H (PiHKAL / Isomer Design)]
-*[http://www.bluelight.org/vb/threads/446462-The-Main-2C-H-Thread 2C-H (Bluelight)]
+===Discussion===
+*[http://www.bluelight.org/vb/threads/446462-The-Main-2C-H-Thread The Main 2C-H Thread (Bluelight)]
 ==References==
-<references/>
+<references />
-[[Category:Phenethylamine]]
+[[Category:Psychoactive substance]]
+[[Category:Psychedelic]]
+[[Category:Stimulant]]
+[[Category:2C-x]]
+[[Category:Research chemical]]