2C-H: Difference between revisions

'''2,5-Dimethoxyphenethylamine''' (also known as '''2C-H''' and '''DMPEA''') is a lesser-known psychoactive substance of the [[chemical class::phenethylamine]] class. 2C-H belongs to the [[2C-x]] family of substituted phenethylamines. However, it does not have psychedelic properties and is primarily used as a precursor in the synthesis of other phenethylamines such as 2C-B, 2C-I, and 2C-N.

2C-H was first synthesized in 1932 by Johannes S. Buck.<ref>Buck, J. S. (1932). HYDROXY-AND DIHYDROXYPHENYLETHYLMETHYLAMINES AND THEIR ETHERS. Journal of the American Chemical Society, 54(9), 3661-3665. https://doi.org/10.1021/ja01348a024.</ref> Its effects in humans were explored in the 1970s by [[Alexander Shulgin]], who published his findings in the book [[PiHKAL|PiHKAL (Phenethylamines I Have Known and Loved)]].  

In PiHKAL, Shulgin lists both the dosage and duration as unknown, commenting that 2C-H is likely easily broken down by MAO enzymes in the liver and is thus probably inactive. However, there have since been some anecdotal reports that suggest it may be active when taken [[sublingually]].<ref>So Happy, Very Happy 2C-H by PandaDoom (Erowid) | https://erowid.org/experiences/exp.php?ID=80334</ref> It is theorized to be [[orally]] active if taken in combination with a [[MAOI]]. However, it is unknown whether this would result in typical 2C-x psychedelic effects.

There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects.<ref>[[Alexander Shlulgin|Shulgin, Alexander]]; [[Ann Shulgin]] (September 1991). [https://www.erowid.org/library/books_online/pihkal/pihkal023.shtml PiHKAL: A Chemical Love Story.] Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.</ref> Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H. However, it has been shown to have binding affinity towards [[Serotonin#The_5-HT_system|5-HT2C]] and [[Serotonin#The_5-HT_system|5-HT2A]] [[receptor]]s in rats.<ref>2C-H BioAssay Results (PubChem) | https://pubchem.ncbi.nlm.nih.gov/compound/76632#section=BioAssay-Results</ref> 2C-H has been shown to inhibit MAO-B activity by over 50% in experiments.<ref name="WagmannBrandt2019">{{cite journal|last1=Wagmann|first1=Lea|last2=Brandt|first2=Simon D.|last3=Stratford|first3=Alexander|last4=Maurer|first4=Hans H.|last5=Meyer|first5=Markus R.|title=Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases|journal=Drug Testing and Analysis|volume=11|issue=2|year=2019|pages=318–324|issn=19427603|doi=10.1002/dta.2494}}</ref>

*'''[[Effect::Color enhancement]]'''

* [https://erowid.org/experiences/exp.php?ID=80334 Erowid Experience Vaults: 2C-H]

Anecdotal reports from those who have tried 2C-H suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Although no formal studies have been conducted, it is not unreasonable to assume that as is the case with psychedelics in general, 2C-H is [[Addiction potential::not habit-forming]] and that the desire to use it can actually decrease with use.  

Tolerance to the effects of 2C-H are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3-5 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7-10 days]] to be back at baseline (in the absence of further consumption). 2C-H presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-H all psychedelics will have a reduced effect.

*'''Austria:''' 2C-H is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).{{citation needed}}

*'''Canada:''' As of October 31st, 2016, 2C-H is a controlled substance (Schedule III) in Canada, and is thus illegal to possess, produce and sell.<ref>http://gazette.gc.ca/rp-pr/p2/2016/2016-05-04/html/sor-dors72-eng.php</ref>

*'''Germany:''' 2C-H is controlled by the NpSG, as it is a derivative of 2-Phenethylamine. Production and sale is illegal. Possession and import, although illegal, is not penalized if intended for self-consumption.<ref>https://www.gesetze-im-internet.de/npsg/anlage.html</ref>

*'''United States:''' As of July 9, 2012, 2C-H is a Schedule I controlled substance in the United States, under the Synthetic Drug Abuse Prevention Act of 2012.<ref>https://www.deadiversion.usdoj.gov/fed_regs/rules/2013/fr0104.htm</ref>

*'''United Kingdom''' - 2C-H is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made</ref>