2C-E: Difference between revisions

2C-E was first synthesized and tested for human activity by [[Alexander Shulgin]] in 1977,<ref name="Shulgin1980"/> who documented his findings in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL"/> It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important [[phenethylamines|phenethylamine]]-derived compounds, all of which except [[mescaline]] he developed and synthesized himself. They are found within the first book of [[PiHKAL]], and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], 2C-E, [[2C-T-2]] and [[2C-T-7]].

2C-E or 2,5-dimethoxy-4-ethylphenethylamine is a [[substituted phenethylamines|phenethylamine]] featuring a phenyl ring bound to an amino (NH₂) group through an ethyl chain. 2C-E contains methoxy functional groups CH₃O- attached to carbons R₂ and R₅ and an ethyl chain bound to carbon R₄ of the phenyl ring. 2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.<ref name="PiHKAL"/>

*'''[[Effect::Stimulation]]''' - 2C-E is usually considered to be very energetic and stimulating in a fashion that is comparable to that of [[MDMA]], although it is 'encouraged' instead of 'forced'.

*'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.

*'''[[Effect::Synaesthesia]]''' - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states. However, many reports indicate that this substance is relatively reliable at inducing synaesthetic states in those who are predisposed to them.{{citation needed}}

Tolerance to the effects of 2C-E are built almost immediately after ingestion. After that, it takes about 1-2 days for the tolerance to be reduced to half and 2-4 days to be back at baseline (in the absence of further consumption). 2C-E presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]] but not evenly, meaning that after the consumption of 2C-E, some psychedelics will have significant reduced effects while some others will only be slighly affected.

*'''Sweden''': 2C-E is a Schedule I drug.{{citation needed}}