Talk:25H-NBOMe: Difference between revisions
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{{SubstanceBox/25H-NBOMe}} | {{SubstanceBox/25H-NBOMe}} | ||
'''25H-NBOMe''' (also known as '''2C-H-NBOMe''', '''NBOMe-2C-H''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces an array of | '''25H-NBOMe''' (also known as '''2C-H-NBOMe''', '''NBOMe-2C-H''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces an array of stimulating and possibly [[psychedelic]] effects when [[Routes of administration|administered]]. | ||
It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. | It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. | ||
Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25H-NBOMe in humans. It had no history of human use before being sold online as a [[designer drug]].{{citation needed}}. It has not officially been associated with fatalities | Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25H-NBOMe in humans. It had no history of human use before being sold online as a [[designer drug]].{{citation needed}}. It has not officially been associated with fatalities like more common members of the [[25x-NBOMe]] family, possibly because it has never have been distributed a lot. Anecdotal reports suggest that this substance may still be difficult to use safely due to its highly sensitive dose-response and unpredictable effects. | ||
It should be worth mentioning, that 25H-NBOMe, according to it's pharmacology on one side, might possess stronger pharmacological effects than other 25x-NBOMe compounds, while on the contrary, the little amount of anecdotal experience reports only describe suble or even just negligible stimulating effects, which might be explained when comparing it to related substances like [[2C-H]] and [[2,5-DMA]].{{citation needed}} | |||
==Chemistry== | ==Chemistry== | ||
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*'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness. | *'''[[Effect::Perception of bodily lightness]]''' - In terms of the body’s perceived weight, this substance consistently leaves people feeling extremely light, often to the point of total weightlessness. | ||
*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed. | *'''[[Effect::Spontaneous physical sensations]]''' - The "body high" itself can be described as a mild, all-encompassing, soft but euphoric tingling sensation. This tingling sensation is also accompanied by spontaneous rushes of [[Physical euphoria|euphoria]] that become longer and more drawn out proportional to the dosage consumed. | ||
*'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual]]ly, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up | *'''[[Effect::Mouth numbing]]''' - Assuming the substance has been taken [[sublingual]]ly, the very first physical effect which a person will notice immediately after sublingual absorption is a strong, unpleasant metallic chemical taste. This is accompanied by a very distinct feeling of general numbness of the tongue and mouth which can stay for up ten hours after the blotter paper has been consumed. | ||
*'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity. | *'''[[Effect::Nausea]]''' - As the user begins to come up, nausea is not uncommon and can sometimes result in initial vomiting, although nausea usually disappears when the user has vomited or the trip fully set in. In comparison to other psychedelics such as [[psilocin]], [[2C-E]] and [[2C-I]], this could actually be considered very mild in its intensity. | ||
*'''[[Effect::Temperature regulation suppression]]''' | *'''[[Effect::Temperature regulation suppression]]''' | ||
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The visual geometry produced by this substance is similar to [[LSD]] and can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colorful in scheme, glossy in color, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within [[2C-I]] and most of the [[2C-x]] family in general as well as completely on par with [[LSD]], [[Psilocin]] and [[DMT]] at appropriately high dosages. | The visual geometry produced by this substance is similar to [[LSD]] and can be comprehensively described as algorithmic in geometric style, intricate in complexity, fine and zoomed out in detail, fast and smooth in motion, structured in shape, colorful in scheme, glossy in color, sharp around the edges and equally angular as well as rounded across their corners. In comparison to other more commonly used psychedelics they can be described as significantly more intricate than the visual geometry found within [[2C-I]] and most of the [[2C-x]] family in general as well as completely on par with [[LSD]], [[Psilocin]] and [[DMT]] at appropriately high dosages. | ||
25H-NBOMe’s geometry leads reliably leads to [[Effect::8A Geometry|Level 8A]] visual geometry with [[Level 8B]] remaining so far unconfirmed. It seems to consistently be able to build up in visual intensity when the user stares at a central point. This eventually envelops the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of immersive physical size attributed to it. | |||
====Hallucinatory states==== | ====Hallucinatory states==== | ||
25H-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently. However, level 4 hallucinatory breakthroughs are reported but very different and inconsistent in comparison to other more commonly used psychedelics such as [[psilocin]], [[2C-E]] and [[DMT]]. | |||
These effects include: | These effects include: | ||
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|{{effects/cognitive| | |{{effects/cognitive| | ||
The cognitive effects of | The cognitive effects of 25H-NBOMe are described by many as notably light in comparison to the classical [[psychedelics]]. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout low to moderate dosages. At high dosages, however, strong to overwhelming cognitive alterations become present, which can lead to states of [[confusion]], [[amnesia]], and general sensory overload. | ||
The most prominent of these cognitive effects generally include: | The most prominent of these cognitive effects generally include: | ||
*'''[[Effect::Analysis enhancement]]''' - This effect is generally only present at low doses. | *'''[[Effect::Analysis enhancement]]''' - This effect is generally only present at low doses. | ||
*'''[[Effect::Thought acceleration]]''' and '''[[Effect::Thought deceleration]]''' - Although one of | *'''[[Effect::Thought acceleration]]''' and '''[[Effect::Thought deceleration]]''' - Although one of 25H-NBOME's effects is thought acceleration, the opposite may occur at higher doses. | ||
*'''[[Effect::Conceptual thinking]]''' - This effect is considered to be very mild compared to traditional psychedlics. | *'''[[Effect::Conceptual thinking]]''' - This effect is considered to be very mild compared to traditional psychedlics. | ||
*'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]''' - This effect seems to occur more readily than other psychedelics, perhaps due to its very prominent stimulating properties | *'''[[Effect::Anxiety]]''' & '''[[Effect::Paranoia]]''' - This effect seems to occur more readily than other psychedelics, perhaps due to its very prominent stimulating properties | ||
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===Experience reports=== | ===Experience reports=== | ||
Anecdotal reports which describe the effects of this compound within our [[experience index]] include: | Anecdotal reports which describe the effects of this compound within our [[experience index]] include: | ||
{{#ask: [[Category: | {{#ask: [[Category:25H-NBOMe]][[Category:Experience]]|format=ul|Columns=1}} | ||
Additional experience reports can be found here: | Additional experience reports can be found here: | ||
*[https://www.erowid.org/experiences/subs/exp_25INBOMe.shtml Erowid Experience Vaults: | <!-- *[https://www.erowid.org/experiences/subs/exp_25INBOMe.shtml Erowid Experience Vaults: 25H-NBOMe] --> | ||
*[https://erowid.org/experiences/exp.php?ID=102545 Erowid Experience: 25H-NBOMe] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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'''Short-term as well as long-term damage of NBOMes have been occasionally tied to serious physical and mental problems on seemingly random people, including memory and speech difficulties, heart problems, HPPD and in some cases Anxiety and PTSD, from particularly difficult experiences.''' | '''Short-term as well as long-term damage of NBOMes have been occasionally tied to serious physical and mental problems on seemingly random people, including memory and speech difficulties, heart problems, HPPD and in some cases Anxiety and PTSD, from particularly difficult experiences.''' | ||
25H-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The [[LD50|LD<sub>50</sub>]] has not yet been determined although it is [[Toxicity::potentially fatal at heavy or very heavy dosages]].<ref>"Fatalities / Deaths". Erowid. April 26, 2013. Retrieved 7 May 2013. | http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome_death.shtml</ref><ref>https://erowid.org/chemicals/nbome/nbome_death.shtml</ref> [[PsychonautWiki]] advises that due to 25H-NBOMe's extreme potency it should not be insufflated as this method of administration appears to have led to several related deaths in the past year.<ref>http://www.erowid.org/chemicals/2ci_nbome/2ci_nbome.shtml/</ref> | |||
The addition of 5-HTP can greatly increase the effects of 25H-NBOME and should be avoided.{{citation needed}} | |||
The addition of 5-HTP can greatly increase the effects of | |||
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance. | It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
25H-NBOMe is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating. | |||
Tolerance to the effects of | Tolerance to the effects of 25H-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25H-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25H-NBOMe all psychedelics will have a reduced effect. | ||
===Overdose=== | ===Overdose=== | ||
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==Legal status== | ==Legal status== | ||
*'''Canada''': 25H-NBOMe would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.<ref>Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28</ref> | |||
*'''Switzerland''': 25H-NBOMe is a controlled substance defined as a derivative of N-benzylphenethylamine under Verzeichnis E point 130 and 131.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref> | |||
*'''United Kingdom''': 25H-NBOMe is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.<ref>United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made</ref> | |||
*'''Canada''': | *'''United States''': 25H-NBOMe can be controlled under the Federal Analog act. | ||
*''' | |||
*'''United Kingdom''': | |||
*'''United States''': | |||
==See also== | ==See also== | ||
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*[[Phenethylamines]] | *[[Phenethylamines]] | ||
*[[25x-NBOMe]] | *[[25x-NBOMe]] | ||
*[[ | *[[25I-NBOMe]] | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/ | *[https://en.wikipedia.org/wiki/25H-NBOMe 25H-NBOMe (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/search.php?domain=pk&id=5386 25H-NBOMe (Isomer Design)] | |||
*[https://isomerdesign.com/PiHKAL/ | |||
==References== | ==References== | ||
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|R2= | |R2= | ||
|R3=OCH₃ | |R3=OCH₃ | ||
|R4= | |R4= | ||
|R5= | |R5= | ||
|R6=OCH₃ | |R6=OCH₃ | ||
}} | }} |