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Promethazine: Difference between revisions
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{{headerpanel|{{Approval}}{{PromethazineOD}}}} | {{headerpanel|{{Approval}}{{PromethazineOD}}}} | ||
{{SummarySheet}} | {{SummarySheet}} | ||
{{ | {{SubstanceBox/Promethazine}} | ||
'''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::phenothiazine]] class. Alongside codeine, it is popularly known as one of the active two ingredients in "lean". It acts as an [[antihistamine]]. | '''Promethazine''' (commonly sold as '''Phenergan''' or '''Lergigan''') is a [[psychoactive class::depressant]] substance of the [[chemical class::phenothiazine]] class. Alongside codeine, it is popularly known as one of the active two ingredients in "lean". It acts as an [[antihistamine]]. | ||
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*'''[[Effect::Muscle relaxation]]''' | *'''[[Effect::Muscle relaxation]]''' | ||
**'''[[Effect::Physical | **'''[[Effect::Physical euphoria]]''' - This can lead to a very pleasant feeling of the entire body relaxing, feeling like warm gel. It is similar to but distinct from an [[opioid]]'s physical euphoria. {{citation needed}} | ||
*'''[[Effect::Increased heart rate]]''' and '''[[Effect::increased blood pressure]]'''<ref name="Tsay2015">{{cite journal | vauthors=((Tsay, M. E.)), ((Procopio, G.)), ((Anderson, B. D.)), ((Klein-Schwartz, W.)) | journal=Journal of Addiction Medicine | title=Abuse and Intentional Misuse of Promethazine Reported to US Poison Centers: 2002 to 2012 | volume=9 | issue=3 | pages=233–237 | date= June 2015 | issn=1935-3227 | doi=10.1097/ADM.0000000000000124}}</ref> - Anticholinergic activity at muscarinic acetylcholine receptors causes these effects. | *'''[[Effect::Increased heart rate]]''' and '''[[Effect::increased blood pressure]]'''<ref name="Tsay2015">{{cite journal | vauthors=((Tsay, M. E.)), ((Procopio, G.)), ((Anderson, B. D.)), ((Klein-Schwartz, W.)) | journal=Journal of Addiction Medicine | title=Abuse and Intentional Misuse of Promethazine Reported to US Poison Centers: 2002 to 2012 | volume=9 | issue=3 | pages=233–237 | date= June 2015 | issn=1935-3227 | doi=10.1097/ADM.0000000000000124}}</ref> - Anticholinergic activity at muscarinic acetylcholine receptors causes these effects. | ||
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==Legal status== | ==Legal status== | ||
*'''Germany''': Promethazine is available through a prescription.{{citation needed}} | |||
*'''Germany''': Promethazine is available through a prescription. | |||
*'''Russia''': Promethazine is available through a prescription.{{citation needed}} | *'''Russia''': Promethazine is available through a prescription.{{citation needed}} | ||
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*'''United States''': Promethazine is available through a prescription.<ref>FDA. Promethazine Monograph. https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/07935s030lbl.pdf</ref> | *'''United States''': Promethazine is available through a prescription.<ref>FDA. Promethazine Monograph. https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/07935s030lbl.pdf</ref> | ||
*'''Canada''': Promethazine is available over the counter. | *'''Canada''': Promethazine is available over the counter.{{citation needed}} | ||
*'''Japan''': Promethazine is available through a prescription. | *'''Japan''': Promethazine is available through a prescription.{{citation needed}} | ||
*'''Australia''': Promethazine is available over the counter.{{citation needed}} | |||
*'''United Kingdom''': Promethazine is available over the counter.{{citation needed}} | |||
==See also== | ==See also== | ||
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*[https://www.erowid.org/pharms/promethazine/ Promethazine (Erowid Vault)] | *[https://www.erowid.org/pharms/promethazine/ Promethazine (Erowid Vault)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=9438 Promethazine (TiHKAL / Isomer Design)] | *[https://isomerdesign.com/PiHKAL/explore.php?id=9438 Promethazine (TiHKAL / Isomer Design)] | ||
*[https://go.drugbank.com/drugs/DB01069 Promethazine (DrugBank)] | |||
==Literature== | ==Literature== | ||
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[[Category:Proofread]] | [[Category:Proofread]] | ||
[[Category:Approval]] | [[Category:Approval]] | ||
[[Category:Deliriant]] | |||