NM-2-AI: Difference between revisions

{{SubstanceBox/NM-2-AI}}

 

'''NM-2-AI''' ('''N-methyl-2-aminoindane''') is a lesser-known novel [[psychoactive class::stimulant]] substance of the [[Chemical class::aminoindane]] class. It is structurally related to [[2-AI]] and [[MDAI]].  

 

In comparison to [[2-AI]], this compound has a lower potency, a longer duration and very similar effects. It has recently become easily accessible  through online [[research chemical]] vendors where it is sold as a [[designer drug]].

 

 

NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of [[2-Aminoindane]] and is analogous to [[amphetamine]]. It features the R₃ terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane, a bicycle containing a benzene ring fused to a pentane ring. The amino group 2-AI shares with amphetamine is bound to R₂ of the indane group. N-methyl-2-AI contains a methyl group bound to the amino group R_N (for which it is named).

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is speculation purely based upon its structure and subjective effect similarities to other [[stimulant]]s such as [[amphetamine]], [[methamphetamine]] and [[2-FMA]]. It is speculated that NM-2-AI most likely acts as both a [[dopamine]] and [[norepinephrine]] [[releasing agent]]. This means it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects.

{{effects/base

|{{effects/physical|

*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, NM-2-AI is usually considered to be energetic and stimulating in a fashion that is similar to that of [[amphetamine]] but stronger than that of [[modafinil]] or [[caffeine]]. It is similar yet distinct from the stimulation experienced on [[MDMA]], encouraging physical activities such as dancing, socializing, running, or cleaning. The particular style of stimulation which NM-2-AI presents can be described as forced. This means that at higher doses, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control.  

*'''[[Effect::Cognitive fatigue]]'''

|{{effects/cognitive|

The cognitive effects of NM-2-AI can be broken down into several components which progressively intensify proportional to dosage. The general head space of NM-2-AI is described by many as one of mental stimulation, increased focus, and euphoria. It contains a large number of typical [[stimulant]] cognitive effects. Although negative side effects are usually mild at low to moderate doses, they become increasingly likely to manifest themselves with higher amounts or extended usage. This particularly holds true during the [[offset]] of the experience.  

*'''[[Effect::Increased music appreciation]]'''

 

 

 

Anecdotal reports which describe the effects of this compound within our [[experience index]] include:

{{#ask: [[Category:NM-2-AI]][[Category:Experience]]|format=ul|Columns=1}}

{{Further|Research chemicals#Toxicity and harm potential}}

The toxicity and long-term health effects of recreational NM-2-AI use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because NM-2-AI has very little history of human usage. Anecdotal evidence from people who have tried NM-2-AI within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).  

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

As with other [[stimulant]]s, the chronic use of NM-2-AI can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

 

Tolerance to many of the effects of NM-2-AI [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). NM-2-AI presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulant]]s]], meaning that after the consumption of NM-2-AI all [[stimulant]]s will have a reduced effect.

Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., [[Paranoia|paranoia]], [[External hallucinations|hallucinations]], or [[Delusions|delusions]]).<ref name="Shoptaw2009">{{cite journal | vauthors=((Shoptaw, S. J.)), ((Kao, U.)), ((Ling, W.)) | veditors=((Cochrane Drugs and Alcohol Group)) | journal=Cochrane Database of Systematic Reviews | title=Treatment for amphetamine psychosis | date=21 January 2009 | url=https://doi.wiley.com/10.1002/14651858.CD003026.pub3 | issn=14651858 | doi=10.1002/14651858.CD003026.pub3}}</ref> A review on treatment for amphetamine, [[dextroamphetamine]], and [[methamphetamine]] abuse-induced psychosis states that about 5–15% of users fail to recover completely.<ref name="Shoptaw2009"></ref><ref>{{cite book | vauthors=((Hofmann, F. G.)) | date= 1983 | title=A handbook on drug and alcohol abuse: the biomedical aspects | publisher=Oxford University Press | edition=2nd ed | isbn=9780195030563}}</ref> The same review asserts that, based upon at least one trial, [[antipsychotic]] medications effectively resolve the symptoms of acute amphetamine psychosis.<ref name="Shoptaw2009"></ref>

 

*'''[[Stimulants]]''' - NM-2-AI can be potentially dangerous in combination with other [[stimulant]]s as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels.

*'''[[Cocaine]]''' - This combination may increase strain on the heart.

==Legal status==

NM-2-AI is currently believed to be a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.

 

[[Category:Substance]]

[[Category:Stimulant]]

[[Category:Psychoactive substance]]

[[Category:Aminoindane]]