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NM-2-AI: Difference between revisions
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'''NM-2-AI''' ('''N-methyl-2-aminoindane''') is a [[psychoactive | '''NM-2-AI''' ('''N-methyl-2-aminoindane''') is a lesser-known novel [[psychoactive class::stimulant]] substance of the [[Chemical class::aminoindane]] class. It is structurally related to [[2-AI]] and [[MDAI]]. | ||
In comparison to [[2-AI]], this compound has a lower potency, a longer duration and very similar effects. It has recently become easily accessible through online [[research chemical]] vendors where it is sold as a [[designer drug]]. | |||
Very little data exists for the effects, pharmacology, and toxicity of NM-2-AI. It is highly advised to use [[harm reduction practices]] if using this substance. | |||
==Chemistry== | ==Chemistry== | ||
NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of [[2-Aminoindane]] and is analogous to [[amphetamine]]. It features the R<sub>3</sub> terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane, a bicycle containing a benzene ring fused to a pentane ring. The amino group 2-AI shares with amphetamine is bound to R<sub>2</sub> of the indane group. N-methyl-2-AI contains a methyl group bound to the amino group R<sub>N</sub> (for which it is named). | NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of [[2-Aminoindane]] and is analogous to [[amphetamine]]. It features the R<sub>3</sub> terminal carbon of the propane chain of amphetamine bound to the benzene ring. This creates an indane, a bicycle containing a benzene ring fused to a pentane ring. The amino group 2-AI shares with amphetamine is bound to R<sub>2</sub> of the indane group. N-methyl-2-AI contains a methyl group bound to the amino group R<sub>N</sub> (for which it is named). | ||
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===Experience reports=== | |||
}} | Anecdotal reports which describe the effects of this compound within our [[experience index]] include: | ||
{{#ask: [[Category:NM-2-AI]][[Category:Experience]]|format=ul|Columns=1}} | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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===Psychosis=== | ===Psychosis=== | ||
{{Main|Stimulant psychosis}} | {{Main|Stimulant psychosis}} | ||
Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., [[Paranoia|paranoia]], [[External hallucinations|hallucinations]], or [[Delusions|delusions]]).<ref>Treatment for amphetamine psychosis | | Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms (e.g., [[Paranoia|paranoia]], [[External hallucinations|hallucinations]], or [[Delusions|delusions]]).<ref name="Shoptaw2009">{{cite journal | vauthors=((Shoptaw, S. J.)), ((Kao, U.)), ((Ling, W.)) | veditors=((Cochrane Drugs and Alcohol Group)) | journal=Cochrane Database of Systematic Reviews | title=Treatment for amphetamine psychosis | date=21 January 2009 | url=https://doi.wiley.com/10.1002/14651858.CD003026.pub3 | issn=14651858 | doi=10.1002/14651858.CD003026.pub3}}</ref> A review on treatment for amphetamine, [[dextroamphetamine]], and [[methamphetamine]] abuse-induced psychosis states that about 5–15% of users fail to recover completely.<ref name="Shoptaw2009"></ref><ref>{{cite book | vauthors=((Hofmann, F. G.)) | date= 1983 | title=A handbook on drug and alcohol abuse: the biomedical aspects | publisher=Oxford University Press | edition=2nd ed | isbn=9780195030563}}</ref> The same review asserts that, based upon at least one trial, [[antipsychotic]] medications effectively resolve the symptoms of acute amphetamine psychosis.<ref name="Shoptaw2009"></ref> | ||
===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
*'''[[Stimulants]]''' - NM-2-AI can be potentially dangerous in combination with other [[stimulant]]s as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | *'''[[Stimulants]]''' - NM-2-AI can be potentially dangerous in combination with other [[stimulant]]s as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | ||
{{DangerousInteractions/Stimulants}} | {{DangerousInteractions/Stimulants}} | ||
*'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | *'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | ||
{{DangerousInteractions/MAOI|nt=dopamine}} | {{DangerousInteractions/MAOI|nt=dopamine}} | ||
*'''[[Cocaine]]''' - This combination may increase strain on the heart. | *'''[[Cocaine]]''' - This combination may increase strain on the heart. | ||
==Legal | ==Legal status== | ||
{{legalStub}} | {{legalStub}} | ||
NM-2-AI is currently believed to be a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume. | NM-2-AI is currently believed to be a grey area compound within most parts of the world. This means that it is not known to be specifically illegal within any country but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume. | ||
*'''United Kingdom''' | |||
*'''Germany''': NM-2-AI is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 23, 2019|language=de}}</ref> as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 23, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 23, 2019|language=de}}</ref> | |||
*'''Switzerland''': NM-2-AI is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref> | |||
*'''United Kingdom''': It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>{{Citation | title=Psychoactive Substances Act 2016 | url=https://www.legislation.gov.uk/ukpga/2016/2/contents/enacted}}</ref> | |||
==See also== | ==See also== | ||
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*[[Amphetamine]] | *[[Amphetamine]] | ||
*[[Methamphetamine]] | *[[Methamphetamine]] | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/NM-2-AI NM-2-AI (Wikipedia)] | *[https://en.wikipedia.org/wiki/NM-2-AI NM-2-AI (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=1327 NM-2-AI (Isomer Design)] | *[https://isomerdesign.com/PiHKAL/explore.php?id=1327 NM-2-AI (Isomer Design)] | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Substance]][[Category:Stimulant]][[Category:Psychoactive substance]][[Category:Aminoindane]][[Category:Research chemical]] | [[Category:Substance]] | ||
[[Category:Stimulant]] | |||
[[Category:Psychoactive substance]] | |||
[[Category:Aminoindane]] | |||
[[Category:Research chemical]] | |||
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