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Methylnaphthidate: Difference between revisions
>David Hedlund *[https://isomerdesign.com/PiHKAL/explore.php?id=10861 HDMP-28 (Isomer Design)] |
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{{SummarySheet}} | {{SummarySheet}} | ||
{{SubstanceBox/Methylnaphthidate}} | {{SubstanceBox/Methylnaphthidate}} | ||
'''Methylnaphthidate''' (also known as '''HDMP-28''') is a novel synthetic [[psychoactive class::stimulant]] substance of the substituted [[chemical class:: | '''Methylnaphthidate''' (also known as '''HDMP-28''') is a novel synthetic [[psychoactive class::stimulant]] substance of the substituted [[chemical class::phenidate]] chemical class. It is a structural analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Concerta'') that produces moderately [[stimulating]] effects when [[Routes of administration|administered]]. | ||
Like members of the [[phenidate]] class, methylnaphthidate is believed to act as a [[monoamine]] [[reuptake inhibitor]].{{citation needed}} However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional [[dopaminergic]] [[stimulant]]. This has been speculated to owe itself to its appreciable effects on [[serotonin]] reuptake inhibition that is not observed in typical methylphenidate analogs.{{citation needed}} | Like members of the [[phenidate]] class, methylnaphthidate is believed to act as a [[monoamine]] [[reuptake inhibitor]].{{citation needed}} However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional [[dopaminergic]] [[stimulant]]. This has been speculated to owe itself to its appreciable effects on [[serotonin]] reuptake inhibition that is not observed in typical methylphenidate analogs.{{citation needed}} | ||
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==Chemistry== | ==Chemistry== | ||
{{chemistry}} | {{chemistry}} | ||
The main structural differences between methylnaphthidate and methylphenidate in chemical substance is the replacement of the core phenyl ring with with a napthalene group. | The main structural differences between methylnaphthidate and [[methylphenidate]] in chemical substance is the replacement of the core phenyl ring with with a napthalene group. | ||
==Pharmacology== | ==Pharmacology== | ||
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}} | }} | ||
{{effects/aftereffects| | |||
{{effects/cognitive| | The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include: | ||
*'''[[Effect::Anxiety]]''' | |||
*'''[[Effect::Cognitive fatigue]]''' | |||
*'''[[Effect::Depression]]''' | |||
*'''[[Effect::Irritability]]''' | |||
*'''[[Effect::Motivation suppression]]''' | |||
*'''[[Effect::Thought deceleration]]''' | |||
*'''[[Effect::Wakefulness]]''' | |||
}} | |||
|{{effects/cognitive| | |||
*'''[[Effect::Thought acceleration]]''' | *'''[[Effect::Thought acceleration]]''' | ||
*'''[[Effect::Analysis enhancement]]''' | *'''[[Effect::Analysis enhancement]]''' | ||
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}} | }} | ||
}} | }} | ||
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{{DangerousInteractions/Stimulants|self=Methylnaphthidate}} | {{DangerousInteractions/Stimulants|self=Methylnaphthidate}} | ||
{{DangerousInteractions/MAOI|nt=serotonin}} | {{DangerousInteractions/MAOI|nt=serotonin}} | ||
*'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with other stimulants. | *'''[[DangerousInteraction::MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with other stimulants. | ||
*'''[[Cocaine]]''' - This combination may synergistically increase strain on the heart to dangerous degrees. | *'''[[DangerousInteraction::Cocaine]]''' - This combination may synergistically increase strain on the heart to dangerous degrees. | ||
==Legal | ==Legal status== | ||
*'''United Kingdom''' | *'''Germany''': HDMP-28 is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 24, 2019|language=de}}</ref> as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 24, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 24, 2019|language=de}}</ref> | ||
*'''United States | *'''Switzerland''': HDMP-28 is a controlled substance specifically named under Verzeichnis E. It was added to the list of controlled substances in December 2015.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref> | ||
*'''Turkey''': HDMP-28 is illegal in Turkey as of February 2016.<ref>{{cite web|url=https://www.resmigazete.gov.tr/eskiler/2016/03/20160308-4.pdf|publisher=Resmi Gazete |access-date=January 15, 2020|language=tr|title=Karar Sayısı : 2016/8548}}</ref> | |||
*'''United Kingdom''': HDMP-28 is a class B drug in the UK as of 31st May 2017 and is illegal to possess, produce or supply. <ref>The Misuse of Drugs Act 1971 (Amendment) Order 2017 (Legislation.gov.uk) | http://www.legislation.gov.uk/uksi/2017/634/made</ref> | |||
*'''United States''': HDMP-28 is not explicitly controlled in the US, but it could possibly be considered an analog of a Schedule II substance (methylphenidate) under the Federal Analog Act. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
<references/> | <references /> | ||
[[Category:Psychoactive substance]] | [[Category:Psychoactive substance]] | ||
[[Category: | [[Category:Phenidate]] | ||
[[Category:Stimulant]] | [[Category:Stimulant]] | ||
[[Category:Research chemical]] | |||
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