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Hexedrone: Difference between revisions

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{{SummarySheet}}
{{SummarySheet}}
{{SubstanceBox/Hexedrone}}
{{SubstanceBox/Hexedrone}}
'''Hexedrone''' is a novel synthetic [[psychoactive class::stimulant]] of the [[chemical class::cathinone]] class. It has been speculated to act as a [[norepinephrine]]-[[dopamine]]-[[reuptake inhibitor|reuptake-inhibitor]] (NDRI).


'''Hexedrone''' is a novel synthetic [[psychoactive class::stimulant]] of the [[chemical category::cathinone]] chemical class that produces [[stimulation]], [[disinhibition]], [[thought acceleration]] and [[euphoria]] when [[Routes of administration|administered]]. Considering the close structurally similarities it share with [[pentedrone]], it has been speculated to act as a [[norepinephrine]]-[[dopamine]]-[[reuptake inhibitor|reuptake-inhibitor]] (NDRI). However, this has yet to be scientifically validated.
[[Subjective effects]] include [[stimulation]], [[disinhibition]], [[thought acceleration]] and [[euphoria]].


Little research exists about both hexedrone, particularly with regards to its toxicity, addiction, and abuse potential. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution.
Little is known about toxicity, addiction, and abuse potential of hexedrone. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with caution.


==Chemistry==
==Chemistry==
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Tolerance to many of the effects of hexedrone [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Hexedrone presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulant]]s]], meaning that after the consumption of Hexedrone all [[stimulant]]s will have a reduced effect.
Tolerance to many of the effects of hexedrone [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). Hexedrone presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic [[stimulant]]s]], meaning that after the consumption of Hexedrone all [[stimulant]]s will have a reduced effect.


==Legal issues==
==Legal status==
{{LegalStub}}
{{LegalStub}}
*'''Brazil:''' On September 7, 2018, all Cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.<ref>New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil</ref>
 
*'''Germany:''' Hexedrone is controlled under the NpSG, as it is a derivative of 2-Phenethylamine. Production and sale is illegal. Possession and import, although illegal, is not penalized if intended for self-consumption.<ref>https://www.gesetze-im-internet.de/npsg/anlage.html</ref>
*'''Brazil''': On September 7, 2018, all Cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.<ref>New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil</ref>
*'''United Kingdom:''' Hexedrone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.<ref>United Kingdom. (2010). Misuse of Drugs Act 1971 (S.I. 2010/1207). London: The Stationery Office Limited. Retrieved February 9, 2018, from https://www.legislation.gov.uk/uksi/2010/1207/made</ref>
*'''Germany''': Hexedrone is controlled under the NpSG (''New Psychoactive Substances Act'')<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/anlage.html|title=Anlage NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 23, 2019|language=de}}</ref> as of November 26, 2016.<ref>{{cite web|url=https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl116s2615.pdf%27%5D__1576017393518|title=Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe|publisher=Bundesanzeiger Verlag|access-date=December 23, 2019|language=de}}</ref> Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.<ref>{{cite web|url=https://www.gesetze-im-internet.de/npsg/__4.html|title=§ 4 NpSG|publisher=Bundesministerium der Justiz und für Verbraucherschutz|access-date=December 23, 2019|language=de}}</ref>
*'''Switzerland''': Hexedrone can be considered a controlled substance as a defined derivative of Cathinone under Verzeichnis E point 1. It is legal when used for scientific or industrial use.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
*'''United Kingdom''': Hexedrone is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.<ref>{{Citation | title=The Misuse of Drugs Act 1971 (Amendment) Order 2010 | url=https://www.legislation.gov.uk/uksi/2010/1207/made}}</ref>


==See also==
==See also==
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==References==
==References==
[[Category:Substance]]
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[[Category:Psychoactive substance]]
[[Category:Psychoactive substance]]
[[Category:Stimulant]]
[[Category:Cathinone]]
[[Category:Cathinone]]
[[Category:Stimulant]]
[[Category:Research chemical]]
[[Category:Proofread]]
[[Category:Proofread]]
<references />
 
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