RIMA: Difference between revisions

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==Interactions==

{{~~mbox|type=notice|text=This section will never be complete since too many psychoactive substances interact with~~ RIMAs~~. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.~~ }}

{{For|psychoactive MAO-A substance interactions (but not food interactions)|MAOI#Interactions}}

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* Naturally occurring sources

===Naturally occurring sources===

** [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]]: [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref> ~~''Peganum harmala'' also contains a [[MAOI]]s.~~

* [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]] (note that it also contains a [[MAOI|MAO-A and MAO-B]] inhibitors)

** Turmeric (''Curcuma longa''): Curcumin<ref>{{cite journal |last1=Kulkarni |first1=SK |last2=Bhutani |first2=AK |last3=Bishnoi |first3=M. |title=Antidepressant activity of curcumin: involvement of serotonin and dopamine system. |journal=Psychopharmacology |date=3 September 2008 |volume=201 |issue=3 |pages=435–442 |doi=10.1007/s00213-008-1300-y |pmid=18766332 }}</ref><ref>{{cite journal |last1=Kulkarni |first1=S. K. |last2=Dhir |first2=A. |title=An Overview of Curcumin in Neurological Disorders |journal=Indian Journal of Pharmaceutical Sciences |date=March 2010 |volume=72 |issue=2 |pages=149–154 |pmc=2929771 |doi=10.4103/0250-474X.65012 |pmid=20838516}}</ref> (selectivity for MAO-A is disputed<ref>{{cite web |title=Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension |url=https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |website=EmediaHealth |date=17 January 2012 |accessdate=28 March 2017 |deadurl=no |archiveurl=https://web.archive.org/web/20170330014040/https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |archivedate=30 March 2017 |df=dmy-all }}</ref>). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition.

** [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref>

* Psychoactive substances

** Harmine

** [[5-IT]]<ref>{{cite journal |url=http://onlinelibrary.wiley.com/doi/10.1002/dta.1530/abstract |title=5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO) |author =Tomás Herraiz |author2 =Simon D. Brandt |journal=Drug Testing and Analysis |date=July–August 2014 |volume=6 |issue=7–8 |pages=607–613 |doi=10.1002/dta.1530 |pmid=24115740}}</ref>

* Turmeric (''Curcuma longa''): Curcumin<ref>{{cite journal |last1=Kulkarni |first1=SK |last2=Bhutani |first2=AK |last3=Bishnoi |first3=M. |title=Antidepressant activity of curcumin: involvement of serotonin and dopamine system. |journal=Psychopharmacology |date=3 September 2008 |volume=201 |issue=3 |pages=435–442 |doi=10.1007/s00213-008-1300-y |pmid=18766332 }}</ref><ref>{{cite journal |last1=Kulkarni |first1=S. K. |last2=Dhir |first2=A. |title=An Overview of Curcumin in Neurological Disorders |journal=Indian Journal of Pharmaceutical Sciences |date=March 2010 |volume=72 |issue=2 |pages=149–154 |pmc=2929771 |doi=10.4103/0250-474X.65012 |pmid=20838516}}</ref> (selectivity for MAO-A is disputed<ref>{{cite web |title=Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension |url=https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |website=EmediaHealth |date=17 January 2012 |accessdate=28 March 2017 |deadurl=no |archiveurl=https://web.archive.org/web/20170330014040/https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |archivedate=30 March 2017 |df=dmy-all }}</ref>). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition.

** [[AMT]]<ref>{{cite journal | vauthors=((Arai, Y.)), ((Toyoshima, Y.)), ((Kinemuchi, H.)) | journal=The Japanese Journal of Pharmacology | title=Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine | volume=41 | issue=2 | pages=191–197 | date= 1986 | doi=10.1254/jjp.41.191}}</ref>

===Pharmaceuticals===

===Psychoactive substances===

* Moclobemide ~~(trade~~ names: Apo-Moclob, Apo-Moclobemide, Auromid, Aurorix, Bei Su, Biorix, Depnil, Eutac, Hai Bei Lin, Langtian, Manerix, Mobemid, Moclamine, Moclo A, Moclobemid - 1 A Pharma, Moclobemid AL, Moclobemid HEXAL, Moclobemid ratiopharm, Moclobemida, Moclobemida Genedec, Moclobemida Teva, Moclobemide Actavis, Moclobemide Aurobindo, Moclobemide CF, Moclobemide Mylan, Moclobemide Sandoz, Moclobemide Sopharma, Moclobemide Teva, Moclobemid-neuraxpharm, Moclobemid-ratiopharm, Moclobeta, Moclod, moclodura, Moclostad, Mocrim, Modafinil Arrow, Moklar, Teva-Moclobemide, Tian Tai, Ya Zheng, and Zorix<ref name=drugs.comINTMoclobemide>{{cite web|title=Moclobemide International Brands|url=https://www.drugs.com/international/Moclobemide.html|publisher=Drugs.com|accessdate=3 June 2017}}</ref>)

* [[5-IT]]<ref>{{cite journal |url=http://onlinelibrary.wiley.com/doi/10.1002/dta.1530/abstract |title=5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO) |author =Tomás Herraiz |author2 =Simon D. Brandt |journal=Drug Testing and Analysis |date=July–August 2014 |volume=6 |issue=7–8 |pages=607–613 |doi=10.1002/dta.1530 |pmid=24115740}}</ref>

* Toloxatone (Humoryl) (available in France)

* [[AMT]]<ref>{{cite journal | vauthors=((Arai, Y.)), ((Toyoshima, Y.)), ((Kinemuchi, H.)) | journal=The Japanese Journal of Pharmacology | title=Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine | volume=41 | issue=2 | pages=191–197 | date= 1986 | doi=10.1254/jjp.41.191}}</ref>

====Pharmaceuticals====

For an updated list of RIMAs, see: [https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#List_of_RIMAs List of RIMAs (Wikipedia)]

=====Moclobemide=====

Trade names: Apo-Moclob, Apo-Moclobemide, Auromid, Aurorix, Bei Su, Biorix, Depnil, Eutac, Hai Bei Lin, Langtian, Manerix, Mobemid, Moclamine, Moclo A, Moclobemid - 1 A Pharma, Moclobemid AL, Moclobemid HEXAL, Moclobemid ratiopharm, Moclobemida, Moclobemida Genedec, Moclobemida Teva, Moclobemide Actavis, Moclobemide Aurobindo, Moclobemide CF, Moclobemide Mylan, Moclobemide Sandoz, Moclobemide Sopharma, Moclobemide Teva, Moclobemid-neuraxpharm, Moclobemid-ratiopharm, Moclobeta, Moclod, moclodura, Moclostad, Mocrim, Modafinil Arrow, Moklar, Teva-Moclobemide, Tian Tai, Ya Zheng, and Zorix)<ref name=drugs.comINTMoclobemide>{{cite web|title=Moclobemide International Brands|url=https://www.drugs.com/international/Moclobemide.html|publisher=Drugs.com|accessdate=3 June 2017}}</ref>

======Tyramine interaction======

With moclobemide doses above 900 mg/d the risk of interaction with ingested tyramine might become clinically relevant.<ref>https://pubmed.ncbi.nlm.nih.gov/12595913/</ref>

==References==

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[[Category:Antidepressant]]

[[Category:Pharmacology]]

@@ Line 4: / Line 4: @@
 ==Interactions==
-{{mbox|type=notice|text=This section will never be complete since too many psychoactive substances interact with RIMAs. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. }}
+{{Information/MAOIs and RIMAs}}
 {{For|psychoactive MAO-A substance interactions (but not food interactions)|MAOI#Interactions}}
@@ Line 17: / Line 17: @@
 {{see also|MAOI#List of MAOIs}}
-* Naturally occurring sources
+===Naturally occurring sources===
-** [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]]: [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref> ''Peganum harmala'' also contains a [[MAOI]]s.
+* [[Peganum harmala (botany)|Syrian rue (''Peganum harmala'')]] (note that it also contains a [[MAOI|MAO-A and MAO-B]] inhibitors)
-** Turmeric (''Curcuma longa''): Curcumin<ref>{{cite journal |last1=Kulkarni |first1=SK |last2=Bhutani |first2=AK |last3=Bishnoi |first3=M. |title=Antidepressant activity of curcumin: involvement of serotonin and dopamine system. |journal=Psychopharmacology |date=3 September 2008 |volume=201 |issue=3 |pages=435–442 |doi=10.1007/s00213-008-1300-y |pmid=18766332 }}</ref><ref>{{cite journal |last1=Kulkarni |first1=S. K. |last2=Dhir |first2=A. |title=An Overview of Curcumin in Neurological Disorders |journal=Indian Journal of Pharmaceutical Sciences |date=March 2010 |volume=72 |issue=2 |pages=149–154 |pmc=2929771 |doi=10.4103/0250-474X.65012 |pmid=20838516}}</ref> (selectivity for MAO-A is disputed<ref>{{cite web |title=Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension |url=https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |website=EmediaHealth |date=17 January 2012 |accessdate=28 March 2017 |deadurl=no |archiveurl=https://web.archive.org/web/20170330014040/https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |archivedate=30 March 2017 |df=dmy-all }}</ref>). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition.
+** [[Harmaline]]<ref>{{ cite book | author = Massaro, E. J. | title = Handbook of Neurotoxicology | publisher = Humana Press | location = Totowa, NJ | year = 2002 | isbn = 0-89603-796-7 | url = https://books.google.com/books?id=2c2K-epbCDQC&pg=PA237&lpg=PA237&dq=harmaline+antidepressant | page = 237 }}</ref>
-* Psychoactive substances
+** Harmine
-** [[5-IT]]<ref>{{cite journal |url=http://onlinelibrary.wiley.com/doi/10.1002/dta.1530/abstract |title=5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO) |author =Tomás Herraiz |author2 =Simon D. Brandt |journal=Drug Testing and Analysis |date=July–August 2014 |volume=6 |issue=7–8 |pages=607–613 |doi=10.1002/dta.1530 |pmid=24115740}}</ref>
+* Turmeric (''Curcuma longa''): Curcumin<ref>{{cite journal |last1=Kulkarni |first1=SK |last2=Bhutani |first2=AK |last3=Bishnoi |first3=M. |title=Antidepressant activity of curcumin: involvement of serotonin and dopamine system. |journal=Psychopharmacology |date=3 September 2008 |volume=201 |issue=3 |pages=435–442 |doi=10.1007/s00213-008-1300-y |pmid=18766332 }}</ref><ref>{{cite journal |last1=Kulkarni |first1=S. K. |last2=Dhir |first2=A. |title=An Overview of Curcumin in Neurological Disorders |journal=Indian Journal of Pharmaceutical Sciences |date=March 2010 |volume=72 |issue=2 |pages=149–154 |pmc=2929771 |doi=10.4103/0250-474X.65012 |pmid=20838516}}</ref> (selectivity for MAO-A is disputed<ref>{{cite web |title=Curcumin and the MAO Inhibitor "Cheese Effect" from Tyramine Triggered Hypertension |url=https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |website=EmediaHealth |date=17 January 2012 |accessdate=28 March 2017 |deadurl=no |archiveurl=https://web.archive.org/web/20170330014040/https://emediahealth.com/2012/01/17/curcumin-and-the-mao-inhibitor-cheese-effect-from-tyramine-triggered-hypertension/ |archivedate=30 March 2017 |df=dmy-all }}</ref>). Curcumin is commonly sold with piperine that enhances the effect of MAO inhibition.
-** [[AMT]]<ref>{{cite journal | vauthors=((Arai, Y.)), ((Toyoshima, Y.)), ((Kinemuchi, H.)) | journal=The Japanese Journal of Pharmacology | title=Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine | volume=41 | issue=2 | pages=191–197 | date= 1986 | doi=10.1254/jjp.41.191}}</ref>
-===Pharmaceuticals===
+===Psychoactive substances===
-* Moclobemide (trade names: Apo-Moclob, Apo-Moclobemide, Auromid, Aurorix, Bei Su, Biorix, Depnil, Eutac, Hai Bei Lin, Langtian, Manerix, Mobemid, Moclamine, Moclo A, Moclobemid - 1 A Pharma, Moclobemid AL, Moclobemid HEXAL, Moclobemid ratiopharm, Moclobemida, Moclobemida Genedec, Moclobemida Teva, Moclobemide Actavis, Moclobemide Aurobindo, Moclobemide CF, Moclobemide Mylan, Moclobemide Sandoz, Moclobemide Sopharma, Moclobemide Teva, Moclobemid-neuraxpharm, Moclobemid-ratiopharm, Moclobeta, Moclod, moclodura, Moclostad, Mocrim, Modafinil Arrow, Moklar, Teva-Moclobemide, Tian Tai, Ya Zheng, and Zorix<ref name=drugs.comINTMoclobemide>{{cite web|title=Moclobemide International Brands|url=https://www.drugs.com/international/Moclobemide.html|publisher=Drugs.com|accessdate=3 June 2017}}</ref>)
+* [[5-IT]]<ref>{{cite journal |url=http://onlinelibrary.wiley.com/doi/10.1002/dta.1530/abstract |title=5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO) |author =Tomás Herraiz |author2 =Simon D. Brandt |journal=Drug Testing and Analysis |date=July–August 2014 |volume=6 |issue=7–8 |pages=607–613 |doi=10.1002/dta.1530 |pmid=24115740}}</ref>
-* Toloxatone (Humoryl) (available in France)
+* [[AMT]]<ref>{{cite journal | vauthors=((Arai, Y.)), ((Toyoshima, Y.)), ((Kinemuchi, H.)) | journal=The Japanese Journal of Pharmacology | title=Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase II. Inhibition by α-Methylated Substrate-Analogue Monoamines, α-Methyltryptamine, α-Methylbenzylamine and Two Enantiomers of α-Methylbenzylamine | volume=41 | issue=2 | pages=191–197 | date= 1986 | doi=10.1254/jjp.41.191}}</ref>
+====Pharmaceuticals====
+For an updated list of RIMAs, see: [https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#List_of_RIMAs List of RIMAs (Wikipedia)]
+=====Moclobemide=====
+Trade names: Apo-Moclob, Apo-Moclobemide, Auromid, Aurorix, Bei Su, Biorix, Depnil, Eutac, Hai Bei Lin, Langtian, Manerix, Mobemid, Moclamine, Moclo A, Moclobemid - 1 A Pharma, Moclobemid AL, Moclobemid HEXAL, Moclobemid ratiopharm, Moclobemida, Moclobemida Genedec, Moclobemida Teva, Moclobemide Actavis, Moclobemide Aurobindo, Moclobemide CF, Moclobemide Mylan, Moclobemide Sandoz, Moclobemide Sopharma, Moclobemide Teva, Moclobemid-neuraxpharm, Moclobemid-ratiopharm, Moclobeta, Moclod, moclodura, Moclostad, Mocrim, Modafinil Arrow, Moklar, Teva-Moclobemide, Tian Tai, Ya Zheng, and Zorix)<ref name=drugs.comINTMoclobemide>{{cite web|title=Moclobemide International Brands|url=https://www.drugs.com/international/Moclobemide.html|publisher=Drugs.com|accessdate=3 June 2017}}</ref>
+======Tyramine interaction======
+With moclobemide doses above 900 mg/d the risk of interaction with ingested tyramine might become clinically relevant.<ref>https://pubmed.ncbi.nlm.nih.gov/12595913/</ref>
 ==References==
@@ Line 40: / Line 48: @@
 [[Category:Antidepressant]]
 [[Category:Pharmacology]]
+{{#set:Featured=true}}