Talk:Kratom: Difference between revisions

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* fixed. thanks. --[[User:White|White]] ([[User talk:White|talk]]) 09:45, 12 April 2020 (UTC)

== ~~Interactions addition~~ ==

== Interaction Warning ==

Kratom inhibits multiple enzymes such as CYP2D6, CYP3A4, and CYP1A2. ~~Some anticoagulant~~ and ~~blood thinner medications~~, ~~Rivaroxaban for example~~, ~~rely on the CYP3A4 enzyme as a major metabolic pathway~~. ~~Those on these medications who are considering taking~~ kratom ~~should be aware of this and I believe blood thinner / anticoagulants should be added~~ to ~~the list~~ of ~~interactions~~. ~~I'm~~ not ~~sure if this edit qualifies~~ as a dangerous ~~interaction, and it certainly is not for all opiates so how would this edit be made to be specific~~ to kratom. ~~What does the community think?~~

Kratom inhibits multiple CYP450 enzymes such as CYP2D6, CYP3A4, and CYP1A2. This has the potential to lead to clinically significant interactions with prescription medication. Also, "Literature indicates that kratom is sometimes fatally mixed with carisoprodol, modafinil, propylhexedrine, Datura stramonium, fentanyl, diphenhydramine, caffeine, morphine, and/or O-desmethyltramadol (Krypton)[7, 8, 21, 35]." (Warner et al 2015) is stated in "The pharmacology and toxicology of kratom: from traditional herb to drug of abuse". Many of the substances listed here are not mentioned as potentially dangerous to mix with kratom.

== Strains section incorrect. Common misunderstanding in kratom ==

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Source (with pictures and videos that convinced me):

https://www.reddit.com/r/kratom/comments/fcwhen/the_truth_on_strains_and_production_personally/

[[User:Javgat|Javgat]] ([[User talk:Javgat|talk]]) 01:49, 2 September 2020 (UTC)

== "It is unlikely that one could ingest a lethal dosage of kratom powder as the nausea will force one to vomit at around 8 - 9 grams" ==

This can't be correct. I occasionally consume standard-strength kratom powder and found that my minimum effective dose is about 12 grams. I'm nowhere near vomiting... In raw powder form it's certainly hard to get down without capsules, so I'm sure there is a vomit limit, but 8-9 grams is way too low.

== kratom extracts ==

Kratom extracts(especially mitragynine extrats can be seen as a whole new level to kratom and can even be seen as completely different drug. does anyone think there should be a section to mitragynine and 7ohm as a standalone substance or make a page? im aware that there is already a page on kratom(this page), but it talks about kratom leaf. kratom extract is so much different than that on that aspect [[User:Novadoesntexist|Novadoesntexist]] ([[User talk:Novadoesntexist|talk]]) 13:27, 5 March 2024 (UTC)

@@ Line 19: / Line 19: @@
 * fixed. thanks. --[[User:White|White]] ([[User talk:White|talk]]) 09:45, 12 April 2020 (UTC)
-== Interactions addition ==
+== Interaction Warning ==
-Kratom inhibits multiple enzymes such as CYP2D6, CYP3A4, and CYP1A2. Some anticoagulant and blood thinner medications, Rivaroxaban for example, rely on the CYP3A4 enzyme as a major metabolic pathway. Those on these medications who are considering taking kratom should be aware of this and I believe blood thinner / anticoagulants should be added to the list of interactions. I'm not sure if this edit qualifies as a dangerous interaction, and it certainly is not for all opiates so how would this edit be made to be specific to kratom. What does the community think?
+Kratom inhibits multiple CYP450 enzymes such as CYP2D6, CYP3A4, and CYP1A2. This has the potential to lead to clinically significant interactions with prescription medication. Also, "Literature indicates that kratom is sometimes fatally mixed with carisoprodol, modafinil, propylhexedrine, Datura stramonium, fentanyl, diphenhydramine, caffeine, morphine, and/or O-desmethyltramadol (Krypton)[7, 8, 21, 35]." (Warner et al 2015) is stated in "The pharmacology and toxicology of kratom: from traditional herb to drug of abuse". Many of the substances listed here are not mentioned as potentially dangerous to mix with kratom.
 == Strains section incorrect. Common misunderstanding in kratom ==
@@ Line 40: / Line 40: @@
 Source (with pictures and videos that convinced me):
 https://www.reddit.com/r/kratom/comments/fcwhen/the_truth_on_strains_and_production_personally/
+[[User:Javgat|Javgat]] ([[User talk:Javgat|talk]]) 01:49, 2 September 2020 (UTC)
+== "It is unlikely that one could ingest a lethal dosage of kratom powder as the nausea will force one to vomit at around 8 - 9 grams" ==
+This can't be correct. I occasionally consume standard-strength kratom powder and found that my minimum effective dose is about 12 grams. I'm nowhere near vomiting... In raw powder form it's certainly hard to get down without capsules, so I'm sure there is a vomit limit, but 8-9 grams is way too low.
+== kratom extracts ==
+Kratom extracts(especially mitragynine extrats can be seen as a whole new level to kratom and can even be seen as completely different drug. does anyone think there should be a section to mitragynine and 7ohm as a standalone substance or make a page? im aware that there is already a page on kratom(this page), but it talks about kratom leaf. kratom extract is so much different than that on that aspect [[User:Novadoesntexist|Novadoesntexist]] ([[User talk:Novadoesntexist|talk]]) 13:27, 5 March 2024 (UTC)