2C-P: Difference between revisions

(17 intermediate revisions by 2 users not shown)

Line 1:

{{headerpanel|{{Template:Warning/2C-P}}}}

Line 15:

Line 16:

==Pharmacology==

2C-P is a relatively potent and long acting psychedelic phenethylamine of the 2C family which possesses stimulant type effects as well. It was first described by Alexander Shulgin in his book ''[[PiHKAL]]''. 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, it can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours.<ref>"Erowid Online Books : "PIHKAL" - #36 2C-P". ''erowid.org''.</ref> 2C-P has been shown to produce a variety of intense [[hallucinogenic]] type effects ranging from drastic changes in consciousness and perception, to open and closed eye visuals. 2C-P is considered to be one of the strongest 2C-x compounds dosage for dosage, rivaled only by 2C-TFM.

2C-P is a relatively potent and long acting psychedelic phenethylamine of the 2C family which possesses stimulant type effects as well. It was first described by Alexander Shulgin in his book ''[[PiHKAL]]''.

2C-P has been shown to produce a variety of intense [[hallucinogenic]] type effects ranging from drastic changes in consciousness and perception, to open and closed eye visuals. 2C-P is considered to be one of the strongest 2C-x compounds dosage for dosage, rivaled only by 2C-TFM.

2C-P's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT2A receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how it results in the [[psychedelic]] experience continues to remain elusive.

Line 110:

Line 113:

==Toxicity and harm potential==

~~{{toxicity}}~~

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational 2C-P use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-P is a [[research chemical]] with very little history of human usage.

Line 119:

Line 121:

===Overdose===

~~The LD50<~~/~~sub> of~~ 2C-P ~~has not been established~~. ~~However, it is believed~~ that ~~2C-P is likely~~ to ~~have~~ a ~~smaller therapeutic window compared~~ to ~~other 2C's, meaning a lethal dose may be achieved more easily~~. 2C-P ~~is known to be highly~~ dose-~~sensitive~~: a ~~difference of 2 or 5~~ milligrams ~~may radically change the nature of the experience along with its safety profile~~. Users who wish to take high doses of this compound are advised to titrate upward slowly, use reliable milligram scales to measure doses, and avoid non-oral routes of administration such as insufflation or injection.

{{GenericPanel/warning

| title=2C-P is difficult to dose properly, and requires patience. Be aware that impulsive overdosing can lead to an overdose. Please structure a calculated dosage regimen and stick to it.

| content=* 2C-P has a '''steep dose-response curve''': As little as a few extra milligrams separating a manageable dose and an overdose.<ref name="Erowid" /> Users who wish to take high doses of this compound are advised to titrate upward slowly, use reliable milligram scales to measure doses, and avoid non-oral routes of administration such as insufflation or injection.

* 2C-P has a '''very slow onset''': The peak effects reportedly do not occur for 1 to 3 hours.<ref name="Erowid">{{Citation | title=Erowid Online Books : “PIHKAL” - #36 2C-P | url=https://www.erowid.org/library/books_online/pihkal/pihkal036.shtml}}</ref> Thus it's advised to wait for ''at least'' 3 hours before re-dosing is considered, and even longer for full stomach content.

* 2C-P has a '''very long half-life''': The anecdotal estimated elimination half-life is 19 hours.<ref>https://pubmed.ncbi.nlm.nih.gov/28130544/</ref>

}}

The LD50 of 2C-P has not been established. However, it is believed that 2C-P is likely to have a smaller therapeutic window compared to other 2C's, meaning a lethal dose may be achieved more easily.

In 2017, a 25-year old British female died following the ingestion of a large dose of 2C-P at a music festival.<ref>{{cite news|author=Steven Morris|date=February 13, 2019|title=Bestival death may be world's first 2C-P fatality, court hears|url=https://www.theguardian.com/uk-news/2019/feb/13/bestival-death-may-be-worlds-first-2-cp-fatality-court-hears|publisher=The Guardian|access-date=October 12, 2020}}</ref> No source reported clear evidence that 2C-P by itself led to the immediate death of the female.

Line 144:

Line 153:

*'''Switzerland''': 2C-P is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>

*'''Turkey:''' 2C-P is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2011/1310|url=https://resmigazete.gov.tr/eskiler/2011/02/20110213-4.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=February 13, 2011|date=January 7, 2011|work=Resmî Gazete, Sayı: 27845|language=tr}}</ref>

*'''The Netherlands:''' 2C-P is currently legal, but it is part of a substance group that may be banned soon as part of a recently passed law on New Psychoactive Substances (NPS). <ref>{{Citation|title= Wijziging van de Opiumwet in verband met het toevoegen van een derde lijst met als doel het tegengaan van de productie van en de handel in nieuwe psychoactieve stoffen en enkele andere wijzigingen (Dutch) | year=2024|url=https://www.tweedekamer.nl/kamerstukken/wetsvoorstellen/detail?id=2022Z14042&dossier=36159}}</ref>

*'''United Kingdom''': 2C-P is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>

*'''United States''': 2C-P is a Schedule I controlled substance.<ref>{{cite letter|url=http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf|publisher=Office of Legislative Affairs|author=Ronald Weich (Assistant Attorney General)|recipient=F. James Sensenbrenner Jr. (Subcommittee on Crime, Terrorism, and Homeland Security)|date=September 30, 2011|subject=Additional Synthetic Drugs for Inclusion in section 202(c) of the Controlled Substances Act}}</ref> This means 2C-P is illegal to manufacture, buy, possess, process, or distribute without a license from the Drug Enforcement Administration (DEA).

@@ Line 1: / Line 1: @@
+{{headerpanel|{{Template:Warning/2C-P}}}}
 {{SummarySheet}}
 {{SubstanceBox/2C-P}}
@@ Line 15: / Line 16: @@
 ==Pharmacology==
 {{Further|Serotonergic psychedelic}}
-C-P is a relatively potent and long acting psychedelic phenethylamine of the 2C family which possesses stimulant type effects as well. It was first described by Alexander Shulgin in his book ''[[PiHKAL]]''. 2C-P is known to have a steep dose-response curve, as little as a few extra milligrams separating a manageable dose and an overdose. Also, it can have a very slow onset if ingested, and peak effects reportedly do not occur for 3 to 5 hours.<ref>"Erowid Online Books : "PIHKAL" - #36 2C-P". ''erowid.org''.</ref> 2C-P has been shown to produce a variety of intense [[hallucinogenic]] type effects ranging from drastic changes in consciousness and perception, to open and closed eye visuals. 2C-P is considered to be one of the strongest 2C-x compounds dosage for dosage, rivaled only by 2C-TFM.
+C-P is a relatively potent and long acting psychedelic phenethylamine of the 2C family which possesses stimulant type effects as well. It was first described by Alexander Shulgin in his book ''[[PiHKAL]]''.
+C-P has been shown to produce a variety of intense [[hallucinogenic]] type effects ranging from drastic changes in consciousness and perception, to open and closed eye visuals. 2C-P is considered to be one of the strongest 2C-x compounds dosage for dosage, rivaled only by 2C-TFM.
 C-P's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT<sub>2A</sub> receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how it results in the [[psychedelic]] experience continues to remain elusive.
@@ Line 110: / Line 113: @@
 ==Toxicity and harm potential==
-{{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
 The toxicity and long-term health effects of recreational 2C-P use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-P is a [[research chemical]] with very little history of human usage.
@@ Line 119: / Line 121: @@
 ===Overdose===
-The LD<sub>50</sub> of 2C-P has not been established. However, it is believed that 2C-P is likely to have a smaller therapeutic window compared to other 2C's, meaning a lethal dose may be achieved more easily. 2C-P is known to be highly dose-sensitive: a difference of 2 or 5 milligrams may radically change the nature of the experience along with its safety profile. Users who wish to take high doses of this compound are advised to titrate upward slowly, use reliable milligram scales to measure doses, and avoid non-oral routes of administration such as insufflation or injection.
+{{GenericPanel/warning
+| title=2C-P is difficult to dose properly, and requires patience. Be aware that impulsive overdosing can lead to an overdose. Please structure a calculated dosage regimen and stick to it.
+| content=* 2C-P has a '''steep dose-response curve''': As little as a few extra milligrams separating a manageable dose and an overdose.<ref name="Erowid" /> Users who wish to take high doses of this compound are advised to titrate upward slowly, use reliable milligram scales to measure doses, and avoid non-oral routes of administration such as insufflation or injection.
+* 2C-P has a '''very slow onset''': The peak effects reportedly do not occur for 1 to 3 hours.<ref name="Erowid">{{Citation | title=Erowid Online Books : “PIHKAL” - #36 2C-P | url=https://www.erowid.org/library/books_online/pihkal/pihkal036.shtml}}</ref> Thus it's advised to wait for ''at least'' 3 hours before re-dosing is considered, and even longer for full stomach content.
+* 2C-P has a '''very long half-life''': The anecdotal estimated elimination half-life is 19 hours.<ref>https://pubmed.ncbi.nlm.nih.gov/28130544/</ref>
+}}
+The LD<sub>50</sub> of 2C-P has not been established. However, it is believed that 2C-P is likely to have a smaller therapeutic window compared to other 2C's, meaning a lethal dose may be achieved more easily.
 In 2017, a 25-year old British female died following the ingestion of a large dose of 2C-P at a music festival.<ref>{{cite news|author=Steven Morris|date=February 13, 2019|title=Bestival death may be world's first 2C-P fatality, court hears|url=https://www.theguardian.com/uk-news/2019/feb/13/bestival-death-may-be-worlds-first-2-cp-fatality-court-hears|publisher=The Guardian|access-date=October 12, 2020}}</ref> No source reported clear evidence that 2C-P by itself led to the immediate death of the female.
@@ Line 144: / Line 153: @@
 *'''Switzerland''': 2C-P is a controlled substance specifically named under Verzeichnis E.<ref>{{cite web|url=https://www.admin.ch/opc/de/classified-compilation/20101220/index.html|title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien|publisher=Bundeskanzlei [Federal Chancellery of Switzerland]|access-date=January 1, 2020|language=de}}</ref>
 *'''Turkey:''' 2C-P is a classed as drug and is illegal to possess, produce, supply, or import.<ref>{{cite web|title=Bakanlar Kurulu Kararı - Karar Sayısı : 2011/1310|url=https://resmigazete.gov.tr/eskiler/2011/02/20110213-4.htm|publisher=Başbakanlık Mevzuatı Geliştirme ve Yayın Genel Müdürlüğü [General Directorate of Legislation Development and Publication]|publication-date=February 13, 2011|date=January 7, 2011|work=Resmî Gazete, Sayı: 27845|language=tr}}</ref>
+*'''The Netherlands:''' 2C-P is currently legal, but it is part of a substance group that may be banned soon as part of a recently passed law on New Psychoactive Substances (NPS). <ref>{{Citation|title= Wijziging van de Opiumwet in verband met het toevoegen van een derde lijst met als doel het tegengaan van de productie van en de handel in nieuwe psychoactieve stoffen en enkele andere wijzigingen (Dutch) | year=2024|url=https://www.tweedekamer.nl/kamerstukken/wetsvoorstellen/detail?id=2022Z14042&dossier=36159}}</ref>
 *'''United Kingdom''': 2C-P is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.<ref>{{cite web|title=Schedule 2: Part I: Class A Drugs|url=http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I|work="Misuse of Drugs Act 1971"|access-date=August 20, 2020|publisher=UK Government}}</ref>
 *'''United States''': 2C-P is a Schedule I controlled substance.<ref>{{cite letter|url=http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf|publisher=Office of Legislative Affairs|author=Ronald Weich (Assistant Attorney General)|recipient=F. James Sensenbrenner Jr. (Subcommittee on Crime, Terrorism, and Homeland Security)|date=September 30, 2011|subject=Additional Synthetic Drugs for Inclusion in section 202(c) of the Controlled Substances Act}}</ref> This means 2C-P is illegal to manufacture, buy, possess, process, or distribute without a license from the Drug Enforcement Administration (DEA).