Talk:MDPHP: Difference between revisions

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{{headerpanel|{{Approval}}}}

'''3',4'-Methylenedioxy-α-pyrrolidinohexiophenone''' (also known as '''MDPHP''' and '''Monkey Dust''') is a synthetic [[~~entactogens|entactogenic~~]] [[~~stimulant~~]] ~~of the~~ [[~~Substituted cathinone~~]] ~~class~~, and its commonly reported effects include [[stimulation]], [[disinhibition]], [[increased libido]], [[compulsive redosing]], and [[euphoria]] when [[Routes_of_administration|administered]] orally, insufflated or smoked.

'''3',4'-Methylenedioxy-α-pyrrolidinohexiophenone''' (also known as '''MDPHP''' and '''Monkey Dust''') is a synthetic [[stimulant]] of the [[substituted cathinone|cathinone]] and [[substituted pyrrolidine|pyrrolidine]] classes, and its commonly reported effects include [[stimulation]], [[disinhibition]], [[increased libido]], [[compulsive redosing]], and [[euphoria]] when [[Routes_of_administration|administered]] orally, insufflated or smoked. MDPHP is thought to act primarily as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI).

Like other [[Substituted cathinone|Substituted cathinones]], MDPHP is associated with compulsive use and addiction. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use [[harm reduction practices]] if choosing to use this substance.

MDPHP was first developed in the 1960s by a team at Boehringer Ingelheim<ref name="KoppePatent">{{Citation | vauthors=((Koppe, H.)), ((Ludwig, G.)), ((Zeile, K.)) | title=Patent DE - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe | url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|date =28 May 1965}}</ref>

Like other [[Substituted cathinone|Substituted cathinones]], MDPHP is associated with compulsive use and addiction. Its stimulating capabilities are strong and the high is good but it has a tax on your cardiovascular system and the crash is hard as well, recovery can take between 1 to 4 days. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use [[harm reduction practices]] if choosing to use this substance.

It is normally available in its freebase form to be vaped or as HCl to be inhaled. In its freebase form it comes as fine tan powder that gets easily turned into a vapour with a gentle usage of a lighter and a thin foil.

==Chemistry==

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However, despite its structural similarity, the effects of MDPHP bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities. It is closely related to the potent stimulant [[MDPV]] though with slightly milder effects and lesser compulsive redosing cravings. Although MDPHP was already first synthetized in 1960's,<ref>{{citation|first1=Koeppe|last1=Herbert|first2=Zeile|last2=Karl|first3=Ludwig|last3=Gerhard|title=Patent DE1545591 - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe|url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|date=28 May 1965|language=de}}</ref> it has been used as an alternative in some countries following the banning of [[MDPV]].

==Subjective effects==

{{effects/base

|{{effects/physical|

MDPHP is a strong stimulant generating a broad spectrum of physical effects:

* '''[[Effect::Stimulation]]'''

* '''[[Effect::Increased libido]]''' - This effect is especially notorious with MDPHP.

* '''[[Effect::Appetite suppression]]'''

* '''[[Effect::Body odor alteration]]'''

* '''[[Effect::Perception of bodily lightness]]'''

* '''[[Effect::Physical euphoria]]'''

* '''[[Effect::Increased blood pressure]]''' - The impact on the cardiovascular system is specially hard with MDPHP.

* '''[[Effect::Increased heart rate]]'''

* '''[[Effect::Vasoconstriction]]'''

* '''[[Effect::Frequent urination]]'''

* '''[[Effect::Muscle cramps]]'''

* '''[[Effect::Teeth grinding]]'''

* '''[[Effect::Temporary erectile dysfunction]]''' - Commonly called ''stimdick''.

}}

{{effects/aftereffects|

The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects can commonly last between 1 and 4 days and they include:

*'''[[Effect::Thought disorganization]]'''

*'''[[Effect::Back pain]]''' - Mostly due to sustained postures over time.

*'''[[Effect::Diarrhea]]'''

*'''[[Effect::Physical fatigue]]''' - This can last some days and it can be pretty intense depending on the dosage.

*'''[[Effect::Dream potentiation]]''' - It is common to have bad dreams during the next days

}}

|{{effects/cognitive|

The general cognitive effects of MDPHP can be described as being similar to those of other typical strong stimulants. At common dosages, the MDPHP high is described as being euphoric and rushy in its effects, causing increased motivation, sociability, sexual desire and concentration. Higher doses of MDPHP, however, can intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.

*'''[[Effect::Increased music appreciation]]'''

*'''[[Effect::Motivation enhancement]]'''

*'''[[Effect::Disinhibition]]'''

*'''[[Effect::Thought disorganization]]'''

*'''[[Effect::Anxiety]]'''

*'''[[Effect::Ego inflation]]''' - Similar to the ego inflation of methamphetamine, MDPHP can induce states of egomania at its peak where the user feels capable of everything.

*'''[[Effect::Focus intensification]]'''

*'''[[Effect::Immersion intensification]]'''

*'''[[Effect::Thought acceleration]]'''

*'''[[Effect::Wakefulness]]'''

*'''[[Effect::Mania]]'''

*'''[[Effect::Paranoia]]''' - Present at high doses or after a long period of continuous usage.

*'''[[Effect::Psychosis]]''' - Same as paranoia.

}}

===Experience reports===

There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].

{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}

Additional experience reports can be found here:

* [https://www.erowid.org/experiences/subs/exp_MDPHP.shtml Erowid Experience Vaults: MDPHP]

===Dangerous interactions===

==Legal status==

==See also==

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* [[3',4'-Methylenedioxy-α-pyrrolidinopropiophenone]] (MDPPP)

* [[N-Ethylhexedrone]]

==References==

@@ Line 1: / Line 1: @@
-{{SubstanceBox}}
+{{headerpanel|{{Approval}}}}
+{{SummarySheet}}
+{{SubstanceBox/MDPHP}}
-'''3',4'-Methylenedioxy-α-pyrrolidinohexiophenone''' (also known as '''MDPHP''' and '''Monkey Dust''') is a synthetic [[entactogens|entactogenic]] [[stimulant]] of the [[Substituted cathinone]] class, and its commonly reported effects include [[stimulation]], [[disinhibition]], [[increased libido]], [[compulsive redosing]], and [[euphoria]] when [[Routes_of_administration|administered]] orally, insufflated or smoked.
+'''3',4'-Methylenedioxy-α-pyrrolidinohexiophenone''' (also known as '''MDPHP''' and '''Monkey Dust''') is a synthetic [[stimulant]] of the [[substituted cathinone|cathinone]] and [[substituted pyrrolidine|pyrrolidine]] classes, and its commonly reported effects include [[stimulation]], [[disinhibition]], [[increased libido]], [[compulsive redosing]], and [[euphoria]] when [[Routes_of_administration|administered]] orally, insufflated or smoked. MDPHP is thought to act primarily as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI).
-Like other [[Substituted cathinone|Substituted cathinones]], MDPHP is associated with compulsive use and addiction. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use [[harm reduction practices]] if choosing to use this substance.
+MDPHP was first developed in the 1960s by a team at Boehringer Ingelheim<ref name="KoppePatent">{{Citation | vauthors=((Koppe, H.)), ((Ludwig, G.)), ((Zeile, K.)) | title=Patent DE - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe | url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|date =28 May 1965}}</ref>
+Like other [[Substituted cathinone|Substituted cathinones]], MDPHP is associated with compulsive use and addiction. Its stimulating capabilities are strong and the high is good but it has a tax on your cardiovascular system and the crash is hard as well, recovery can take between 1 to 4 days. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use [[harm reduction practices]] if choosing to use this substance.
+It is normally available in its freebase form to be vaped or as HCl to be inhaled. In its freebase form it comes as fine tan powder that gets easily turned into a vapour with a gentle usage of a lighter and a thin foil.
 ==Chemistry==
@@ Line 12: / Line 18: @@
 However, despite its structural similarity, the effects of MDPHP bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities. It is closely related to the potent stimulant [[MDPV]] though with slightly milder effects and lesser compulsive redosing cravings. Although MDPHP was already first synthetized in 1960's,<ref>{{citation|first1=Koeppe|last1=Herbert|first2=Zeile|last2=Karl|first3=Ludwig|last3=Gerhard|title=Patent DE1545591 - Verfahren zur Herstellung von α-Aminoketonen mit heterocyclischer Aminogruppe|url=https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19690807&DB=&locale=en_EP&CC=DE&NR=1545591A1&KC=A1|date=28 May 1965|language=de}}</ref> it has been used as an alternative in some countries following the banning of [[MDPV]].
+==Subjective effects==
+{{Preamble/SubjectiveEffects}}
+{{effects/base
+|{{effects/physical|
+MDPHP is a strong stimulant generating a broad spectrum of physical effects:
+* '''[[Effect::Stimulation]]'''
+* '''[[Effect::Increased libido]]''' - This effect is especially notorious with MDPHP.
+* '''[[Effect::Appetite suppression]]'''
+* '''[[Effect::Body odor alteration]]'''
+* '''[[Effect::Perception of bodily lightness]]'''
+* '''[[Effect::Physical euphoria]]'''
+* '''[[Effect::Increased blood pressure]]''' - The impact on the cardiovascular system is specially hard with MDPHP.
+* '''[[Effect::Increased heart rate]]'''
+* '''[[Effect::Vasoconstriction]]'''
+* '''[[Effect::Frequent urination]]'''
+* '''[[Effect::Muscle cramps]]'''
+* '''[[Effect::Teeth grinding]]'''
+* '''[[Effect::Temporary erectile dysfunction]]''' - Commonly called ''stimdick''.
+}}
+{{effects/aftereffects|
+The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects can  commonly last between 1 and 4 days and they include:
+*'''[[Effect::Thought disorganization]]'''
+*'''[[Effect::Back pain]]''' - Mostly due to sustained postures over time.
+*'''[[Effect::Diarrhea]]'''
+*'''[[Effect::Physical fatigue]]''' - This can last some days and it can be pretty intense depending on the dosage.
+*'''[[Effect::Dream potentiation]]''' - It is common to have bad dreams during the next days
+}}
+|{{effects/cognitive|
+The general cognitive effects of MDPHP can be described as being similar to those of other typical strong stimulants. At common dosages, the MDPHP high is described as being euphoric and rushy in its effects, causing increased motivation, sociability, sexual desire and concentration. Higher doses of MDPHP, however, can intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.
+*'''[[Effect::Increased music appreciation]]'''
+*'''[[Effect::Motivation enhancement]]'''
+*'''[[Effect::Disinhibition]]'''
+*'''[[Effect::Thought disorganization]]'''
+*'''[[Effect::Anxiety]]'''
+*'''[[Effect::Ego inflation]]''' - Similar to the ego inflation of methamphetamine, MDPHP can induce states of egomania at its peak where the user feels capable of everything.
+*'''[[Effect::Focus intensification]]'''
+*'''[[Effect::Immersion intensification]]'''
+*'''[[Effect::Thought acceleration]]'''
+*'''[[Effect::Wakefulness]]'''
+*'''[[Effect::Mania]]'''
+*'''[[Effect::Paranoia]]''' - Present at high doses or after a long period of continuous usage.
+*'''[[Effect::Psychosis]]''' - Same as paranoia.
+}}
+}}
+===Experience reports===
+There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
+{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}
+Additional experience reports can be found here:
+* [https://www.erowid.org/experiences/subs/exp_MDPHP.shtml Erowid Experience Vaults: MDPHP]
+===Dangerous interactions===
+{{Template:DangerousInteractions/Intro}}
+{{Template:DangerousInteractions/Stimulants}}
+==Legal status==
+{{legalStub}}
 ==See also==
@@ Line 19: / Line 92: @@
 * [[3',4'-Methylenedioxy-α-pyrrolidinopropiophenone]] (MDPPP)
 * [[N-Ethylhexedrone]]
+==References==
+<references />