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MDMA/Synthesis: Difference between revisions

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=== Synthesis ===
=== Synthesis ===


* From piperonal (with nitromethane) to the nitroethylene; (with electrolytic reduction) to MDPEA (Tanaka and Midzuno, 1929).
* From safrole (with aqueous HBr) to 5-(2-bromopropyl)benzo-1,3-dioxole; (with methyl­ amine in EtOH) to MDMA (Merck, 1912; Bineicki and Krajewski, 1960).
* From 3,4-methylenedioxybenzaldehyde (with malonic acid) to 3,4-methylenedioxycin­ namic acid; (with Na, Hg) to 3,4-methylenedioxypropionic acid; (with NH3) to 3,4-methyl­ enedioxypropionamide; (with NaOCl) to MDPEA (Slotta and Heller, 1930).
* From 3,4-methylenedioxyphenylacetone (aka: piperonylacetone; with methylamine, sodium cyanoborohydride) to MDMA (Braun et al., 1980).
* From 3,4-methylenedioxyhydrocinnamamide (Kindler, 1931).
* From MDA (with formic acid or ethyl formate) to ''N''-formyl-3,4-methylenedioxy­ amphetamine; (with LAH) to MDMA (Shulgin and Shulgin, 1991)
* From piperonal (with nitromethane) to the nitroethylene; (with Pd, H2) to MDPEA (Schales, 1935a; Maurer and Schiedt, 1935).
* From isosafrole (with formic acid, H<sub>2</sub>0<sub>2</sub>) to 3,4-methylenedioxyphenylacetone; (with Al, HgCl<sub>2</sub>, CH<sub>3</sub>NH<sub>2</sub>) to MDMA (Shulgin and Shulgin, 1991).
* Synthesis by catalytic hydrogenation of homopiperonyloximine (Schales 1935b).
* (For the optical isomers) from piperonylacetone (with ''R''-(-)- (or ''S''-(+)-) &alpha;-methylbenzyl­ amine, Raney Ni) to ''R'',''R''- (or ''S'',''S'') ''N''-&alpha;-methylbenzyl-MOA; (with Pd, H<sub>2</sub>) to ''R''-(-)- (or ''S''-(+)-) MDA; (with methyl formate) to ''R''-(+)- (or ''S''-(-) ''N''-formamido-MDA; (with LAH) to ''R''-(-)­ (or ''S''-(+)-) MDMA (Anderson et al., 1978a).
* From piperonal (with nitromethane) to the nitroethylene; (with LAH) to MDPEA (Erne and Ramirez, 1950; Dallacker et al., 1971).
* From piperonal (with nitromethane) to the nitroethylene; (with Raney Ni, or Raney Co, H2) to MDPEA (Reeve and Eareckson, 1950).
* From piperonal (with malonic acid) to 3,4-methylenedioxycinnamic acid; (with Pd, H2) to 3,4-methylenedioxyphenylpropionic acid; (with SOCL2, NH3) to 3,4-methylenedioxyphen­ylpropionamide; (with aq. KOCI ) to MDPEA (Habermehl and Khalique, 1967).
* Synthesis by reduction of the 2-nitrophenylethane with Fe powder in ethanol in the presence of ammonium chloride (Ran et al., 2000).


== M. Swist, J. Wilamowski, A. Parczewski ==
== M. Swist, J. Wilamowski, A. Parczewski ==
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Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis, and impurity profiles were obtained.
Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis, and impurity profiles were obtained.


=== External links ===
* [https://isomerdesign.com/PiHKAL/read.php?domain=pk&id=109 MDMA (PiHKAL: A Chemical Love Story)]
=== References ===
<references/>
<references/>
[[category:Chemical synthesis]]
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