Psilocybin mushroom lemon tek: Difference between revisions

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{{mbox|type=notice|text=Users should note that there is no research to support the lemon tek theory specifically, though science does support the concept of acidic environments converting psilocybin into psilocin. Some, if not all the effects may be attributed to placebo effect.}}

==Theoretical modes of action==

===Dephosphorylation===

Psilocybin is a [[prodrug]] to [[psilocin]], which is primarily responsible for the psychoactive effects of [[psilocybin mushrooms]]. The conversion process, known as dephosphorylation, begins upon entering the stomach. This is one of the reasons why psilocybin mushrooms take about an hour before their effects begin.

The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated <ref>Hallucinogenic mushrooms drug profile ~~- http~~://www.emcdda.europa.eu/publications/drug-profiles/~~mushrooms~~</ref> into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.<ref>~~Ricardo Jorge~~ Dinis-Oliveira (2017~~) [~~https://doi.~~org~~/10.1080/03602532.2016.1278228 ~~Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance], Drug Metabolism Reviews, 49:1, 84-91,~~</ref> In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).<ref>Marieb EN, Hoehn K (2010). Human anatomy & physiology~~. San Francisco:~~ Benjamin Cummings~~. ISBN 0-8053-9591-1.~~</ref> Purported effects include faster onset, a more intense trip, and reduced nausea.

The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated <ref>{{Citation | title=Hallucinogenic mushrooms drug profile | url=https://www.emcdda.europa.eu/publications/drug-profiles/hallucinogenic-mushrooms_en}}</ref> into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.<ref>{{cite journal | vauthors=((Dinis-Oliveira, R. J.)) | journal=Drug Metabolism Reviews | title=Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance | volume=49 | issue=1 | pages=84–91 | date=2 January 2017 | url=https://www.tandfonline.com/doi/full/10.1080/03602532.2016.1278228 | issn=0360-2532 | doi=10.1080/03602532.2016.1278228}}</ref> In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).<ref>{{cite book | vauthors=((Marieb, E. N.)), ((Hoehn, K.)) | date= 2010 | title=Human anatomy & physiology | publisher=Benjamin Cummings | isbn=9780805395914}}</ref> Purported effects include faster onset, a more intense trip, and reduced nausea.

===Increased absorption===

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-{{mbox|type=notice|text=Users should note that there is no research to support the lemon tek theory specifically, though science does support the concept of acidic environments converting psilocybin into psilocin. Some, if not all the effects may be attributed to placebo effect.}}
 ==Theoretical modes of action==
+{{Information/Psilocybin mushroom lemon tek}}
 ===Dephosphorylation===
 Psilocybin is a [[prodrug]] to [[psilocin]], which is primarily responsible for the psychoactive effects of [[psilocybin mushrooms]]. The conversion process, known as dephosphorylation, begins upon entering the stomach. This is one of the reasons why psilocybin mushrooms take about an hour before their effects begin.
-The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated <ref>Hallucinogenic mushrooms drug profile - http://www.emcdda.europa.eu/publications/drug-profiles/mushrooms</ref> into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.<ref>Ricardo Jorge Dinis-Oliveira (2017) [https://doi.org/10.1080/03602532.2016.1278228 Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance], Drug Metabolism Reviews, 49:1, 84-91,</ref> In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).<ref>Marieb EN, Hoehn K (2010). Human anatomy & physiology. San Francisco: Benjamin Cummings. ISBN 0-8053-9591-1.</ref> Purported effects include faster onset, a more intense trip, and reduced nausea.
+The lemon tek theory suggests the acid in the lemon juice jump starts the conversion of psilocybin into psilocin. There are two processes by which psilocybin can be dephosphorylated <ref>{{Citation | title=Hallucinogenic mushrooms drug profile | url=https://www.emcdda.europa.eu/publications/drug-profiles/hallucinogenic-mushrooms_en}}</ref> into psilocin- either via the alkaline phosphatase enzyme in the intestine and kidney, or in acidic environments like the stomach.<ref>{{cite journal | vauthors=((Dinis-Oliveira, R. J.)) | journal=Drug Metabolism Reviews | title=Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance | volume=49 | issue=1 | pages=84–91 | date=2 January 2017 | url=https://www.tandfonline.com/doi/full/10.1080/03602532.2016.1278228 | issn=0360-2532 | doi=10.1080/03602532.2016.1278228}}</ref> In theory, lemon juice, which has a pH of around 2, should be acidic enough to dephosphorylate psilocybin in the same way the stomach can (with a pH of 1.5 to 3.5 in humans).<ref>{{cite book | vauthors=((Marieb, E. N.)), ((Hoehn, K.)) | date= 2010 | title=Human anatomy & physiology | publisher=Benjamin Cummings | isbn=9780805395914}}</ref> Purported effects include faster onset, a more intense trip, and reduced nausea.
 ===Increased absorption===