Talk:Autism spectrum: Difference between revisions

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There are some very interesting developments in autism research which are not yet published but have been presented in several meetings. Alan Friedman, Ph.D., is a chemist who works for the Ortho Clinical Diagnostics division of Johnson & Johnson. He was interested in the opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin. This is where the rationale for the gluten-free, casein-free diet came from. Many children with autism (some but not all) do not seem to break gluten and casein down completely, but rather keep their metabolites casomorphine and gliadomorphin intact which then get into the bloodstream (and therefore into the urine).

"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>

==Cannabinoids==

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==Opioids==

{{see also|https://en.wikipedia.org/wiki/Opioid_excess_theory Opioid excess theory (Wikipedia)}}

"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>

===Endogenous opioids===

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* [https://www.ncbi.nlm.nih.gov/pubmed/27304256 Opioid peptides and gastrointestinal symptoms in autism spectrum disorders.]

* [https://www.ncbi.nlm.nih.gov/pubmed/7890130 Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.]

==Oxytocin==

* Meta-analysis: In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of oxytocin administration were tested, with doses ranging from 15 IU to more than 7000 IU. However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669921/</ref>

==Serotonin==

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-There are some very interesting developments in autism research which are not yet published but have been presented in several meetings. Alan Friedman, Ph.D., is a chemist who works for the Ortho Clinical Diagnostics division of Johnson & Johnson. He was interested in the opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin. This is where the rationale for the gluten-free, casein-free diet came from. Many children with autism (some but not all) do not seem to break gluten and casein down completely, but rather keep their metabolites casomorphine and gliadomorphin intact which then get into the bloodstream (and therefore into the urine).
-"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>
 ==Cannabinoids==
@@ Line 40: / Line 37: @@
 ==Opioids==
 {{see also|https://en.wikipedia.org/wiki/Opioid_excess_theory Opioid excess theory (Wikipedia)<!-- "The opioid excess theory is a theory which postulates that autism..." -->}}
+"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>
 ===Endogenous opioids===
@@ Line 49: / Line 48: @@
 * [https://www.ncbi.nlm.nih.gov/pubmed/27304256 Opioid peptides and gastrointestinal symptoms in autism spectrum disorders.]
 * [https://www.ncbi.nlm.nih.gov/pubmed/7890130 Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.]
+==Oxytocin==
+* Meta-analysis: In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of oxytocin administration were tested, with doses ranging from 15 IU to more than 7000 IU. However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669921/</ref>
 ==Serotonin==