Talk:Autism spectrum: Difference between revisions

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==~~Endocannabinoids==~~

{{mbox|type=notice|text=* What are we trying to say in that article?

* ~~[https~~:~~//www~~.~~ncbi.nlm.nih.gov/pubmed/30171992 Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.]~~

* What's actual established science for that topic?

* What are things to consider?

* What are the implications in regard to psychonautics?

* Can autists be psychonauts? Or are psychedelics mostly just relaxing for them?

* Consider "Category:Psychiatric diagnosis" to this page if it gets moved to main space.

}}

==Cannabinoids==

===Endocannabinoids===

* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604173/ Endocannabinoid Signaling in Autism]

* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618565/ The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models]

* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535348/ Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention]

* [https://www.ncbi.nlm.nih.gov/pubmed/28880200 The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.]

===Pharmacotherapy===

* [[CBD]]: [https://www.ncbi.nlm.nih.gov/pubmed/30171992 Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.]

==Dopamine==

===Endogenous dopamine===

* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374973/ Dopamine and the Development of Executive Dysfunction in Autism Spectrum Disorders]

* [https://www.ncbi.nlm.nih.gov/pubmed/28750400 A Dopamine Hypothesis of Autism Spectrum Disorder.]

* [https://www.ncbi.nlm.nih.gov/pubmed/24412511 Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).]

==Melatonin==

===Endogenous melatonin===

* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478596/ Melatonin in Children with Autism Spectrum Disorders: How Does the Evidence Fit Together?]

* [https://www.ncbi.nlm.nih.gov/pubmed/24050742 Melatonin in autism spectrum disorders.]

* [https://www.ncbi.nlm.nih.gov/pubmed/21518346 Melatonin in autism spectrum disorders: a systematic review and meta-analysis.]

==Opioids==

{{see also|https://en.wikipedia.org/wiki/Opioid_excess_theory Opioid excess theory (Wikipedia)}}

"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>

===Endogenous opioids===

* [https://www.ncbi.nlm.nih.gov/pubmed/7010949 Biologically active peptide-containing fractions in schizophrenia and childhood autism.]

* [https://www.ncbi.nlm.nih.gov/pubmed/3038836 Brain opioids and autism: an updated analysis of possible linkages.]

* [https://www.ncbi.nlm.nih.gov/pubmed/12578238 Opioid peptides and dipeptidyl peptidase in autism.]

* [https://www.ncbi.nlm.nih.gov/pubmed/28369738 μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.]

* [https://www.ncbi.nlm.nih.gov/pubmed/12223079 Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention.]

* [https://www.ncbi.nlm.nih.gov/pubmed/27304256 Opioid peptides and gastrointestinal symptoms in autism spectrum disorders.]

* [https://www.ncbi.nlm.nih.gov/pubmed/7890130 Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.]

==Oxytocin==

* Meta-analysis: In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of oxytocin administration were tested, with doses ranging from 15 IU to more than 7000 IU. However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669921/</ref>

==Serotonin==

===Endogenous serotonin===

* [https://www.ncbi.nlm.nih.gov/m/pubmed/16648340/ Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study.]

* [http://www.ncbi.nlm.nih.gov/pubmed/20150873 Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.]

===Pharmacotherapy===

* [[LSD]]: [https://www.ncbi.nlm.nih.gov/pubmed/17608329 Flashback to the 1960s: LSD in the treatment of autism.]

====Entacogens====

* [[MDMA]]: [https://www.ncbi.nlm.nih.gov/pubmed/25818246 MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults.]

* [[MDMA]]: [https://www.ncbi.nlm.nih.gov/pubmed/30196397 Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study.]

==See also==

* [[Talk:Pharmaceutical]]

* [[Talk:Psychiatric diagnoses]]

==External links==

* [https://en.wikipedia.org/wiki/Autism_spectrum Autism spectrum (Wikipedia)]

@@ Line 1: / Line 1: @@
-==Endocannabinoids==
+{{mbox|type=notice|text=* What are we trying to say in that article?
-* [https://www.ncbi.nlm.nih.gov/pubmed/30171992 Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.]
+* What's actual established science for that topic?
+* What are things to consider?
+* What are the implications in regard to psychonautics?
+* Can autists be psychonauts? Or are psychedelics mostly just relaxing for them?
+* Consider "Category:Psychiatric diagnosis" to this page if it gets moved to main space.
+}}
+==Cannabinoids==
+===Endocannabinoids===
 * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604173/ Endocannabinoid Signaling in Autism]
 * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618565/ The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models]
 * [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535348/ Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention]
 * [https://www.ncbi.nlm.nih.gov/pubmed/28880200 The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.]
+===Pharmacotherapy===
+{{for|substances|Cannabinoid}}
+* [[CBD]]: [https://www.ncbi.nlm.nih.gov/pubmed/30171992 Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.]
+==Dopamine==
+===Endogenous dopamine===
+* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374973/ Dopamine and the Development of Executive Dysfunction in Autism Spectrum Disorders]
+* [https://www.ncbi.nlm.nih.gov/pubmed/28750400 A Dopamine Hypothesis of Autism Spectrum Disorder.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/24412511 Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).]
+==Melatonin==
+===Endogenous melatonin===
+* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478596/ Melatonin in Children with Autism Spectrum Disorders: How Does the Evidence Fit Together?]
+* [https://www.ncbi.nlm.nih.gov/pubmed/24050742 Melatonin in autism spectrum disorders.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/21518346 Melatonin in autism spectrum disorders: a systematic review and meta-analysis.]
+==Opioids==
+{{see also|https://en.wikipedia.org/wiki/Opioid_excess_theory Opioid excess theory (Wikipedia)<!-- "The opioid excess theory is a theory which postulates that autism..." -->}}
+"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"<ref>{{cite web |url=http://www.bbbautism.com/pdf/article_14_why_does_gfcf_work.pdf}}</ref>
+===Endogenous opioids===
+* [https://www.ncbi.nlm.nih.gov/pubmed/7010949 Biologically active peptide-containing fractions in schizophrenia and childhood autism.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/3038836 Brain opioids and autism: an updated analysis of possible linkages.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/12578238 Opioid peptides and dipeptidyl peptidase in autism.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/28369738 μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/12223079 Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/27304256 Opioid peptides and gastrointestinal symptoms in autism spectrum disorders.]
+* [https://www.ncbi.nlm.nih.gov/pubmed/7890130 Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.]
+==Oxytocin==
+* Meta-analysis: In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of oxytocin administration were tested, with doses ranging from 15 IU to more than 7000 IU. However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669921/</ref>
 ==Serotonin==
+===Endogenous serotonin===
 * [https://www.ncbi.nlm.nih.gov/m/pubmed/16648340/ Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study.]
+* [http://www.ncbi.nlm.nih.gov/pubmed/20150873 Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.]
+===Pharmacotherapy===
+{{for|substances|Serotonin}}
+* [[LSD]]: [https://www.ncbi.nlm.nih.gov/pubmed/17608329 Flashback to the 1960s: LSD in the treatment of autism.]
+====Entacogens====
+* [[MDMA]]: [https://www.ncbi.nlm.nih.gov/pubmed/25818246 MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults.]
+* [[MDMA]]: [https://www.ncbi.nlm.nih.gov/pubmed/30196397 Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study.]
+==See also==
+* [[Talk:Pharmaceutical]]
+* [[Talk:Psychiatric diagnoses]]
+==External links==
+* [https://en.wikipedia.org/wiki/Autism_spectrum Autism spectrum (Wikipedia)]