Template:DangerousInteractions/Dissociatives: Difference between revisions

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*'''[[Depressants]]''' (''~~[[1,4-Butanediol]],~~ [[2M2B]], [[alcohol]], [[~~benzodiazepines~~]], [[~~barbiturates~~]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination potentiates the [[muscle relaxation]], [[amnesia]], [[sedation]], and [[respiratory depression]] caused by one another and at higher doses, can lead to a sudden, unexpected loss of consciousness along with dangerously depressed respiration. There is also an increased risk of vomiting while unconsciousness and dying from the resulting suffocation. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[DangerousInteraction::Depressants|Depressants]]''' (e.g. '''''[[2M2B]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]''''') - This combination potentiates the [[muscle relaxation]], [[amnesia]], [[sedation]], and [[respiratory depression]] caused by one another and at higher doses, can lead to a sudden, unexpected loss of consciousness along with dangerously depressed respiration. There is also an increased risk of vomiting while unconsciousness and dying from the resulting suffocation. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[Stimulants]]''' - This combination can potentiate the [[anxiety]]-inducing, [[mania|manic]], [[delusion|delusional]] and [[disinhibition|disinhibiting]] effects of dissociatives, particularly those without pronounced [[motor control loss|motor suppressing]] components such as [[ketamine]]. The sum of these effects can increase the likelihood of an anxiety attack, delusions or a [[psychosis|psychotic episode~~]].~~

*'''[[DangerousInteraction::Stimulants|Stimulants]]''' (e.g. '''''[[amphetamine]], [[cocaine]], [[methylphenidate]], [[MDMA]]''''') - This combination can potentiate the [[anxiety]]-inducing, [[mania|manic]], [[delusion|delusional]] and [[disinhibition|disinhibiting]] effects of dissociatives, particularly those without pronounced [[motor control loss|motor suppressing]] components such as [[ketamine]]. The sum of these effects can increase the likelihood of an anxiety attack, delusions or a [[psychosis|psychotic episode]]. There is also evidence that suggests that combining these two increases their neurotoxicity.{{citation needed}} Anecdotally, worsened comedowns are also commonly reported when these two classes of substances are combined.

*'''[[DangerousInteraction::Dissociatives|Dissociatives]]''' (e.g. '''''[[dextromethorphan]], [[ketamine]], [[methoxetamine]], [[PCP]]''''') - Combination can unpredictably potentiate [[amnesia]], [[sedation]], [[motor control loss]] and [[delusions]]. It may also result in a sudden loss of consciousness along with a dangerous amount of [[respiratory depression]]. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

~~:Prominent examples include [[PCP]] and its analogs [[3-MeO-PCP]], [[MXE]], and the [[diarylethylamine]] dissociatives like [[diphenidine]] or [[ephenidine~~]]. There is also evidence that suggests that combining these two increases their neurotoxicity.{{citation needed}} Anecdotally, worsened comedowns are also commonly reported when these two classes of substances are combined.

*'''[[Dissociatives]]''' - ~~This combination~~ can unpredictably potentiate ~~the~~ [[amnesia]], [[sedation]], [[motor control loss]] and [[delusions]] ~~that can be caused by each other~~. It may also result in a sudden loss of consciousness ~~accompanied by~~ a dangerous ~~degree~~ of [[respiratory depression]]. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

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-*'''[[Depressants]]''' (''[[1,4-Butanediol]], [[2M2B]], [[alcohol]], [[benzodiazepines]], [[barbiturates]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]'') - This combination potentiates the [[muscle relaxation]], [[amnesia]], [[sedation]], and [[respiratory depression]] caused by one another and at higher doses, can lead to a sudden, unexpected loss of consciousness along with dangerously depressed respiration. There is also an increased risk of vomiting while unconsciousness and dying from the resulting suffocation. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
+*'''[[DangerousInteraction::Depressants|Depressants]]''' (e.g. '''''[[2M2B]], [[alcohol]], [[barbiturates]], [[benzodiazepines]], [[GHB]]/[[GBL]], [[methaqualone]], [[opioids]]''''') - This combination potentiates the [[muscle relaxation]], [[amnesia]], [[sedation]], and [[respiratory depression]] caused by one another and at higher doses, can lead to a sudden, unexpected loss of consciousness along with dangerously depressed respiration. There is also an increased risk of vomiting while unconsciousness and dying from the resulting suffocation. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
-*'''[[Stimulants]]''' - This combination can potentiate the [[anxiety]]-inducing, [[mania|manic]], [[delusion|delusional]] and [[disinhibition|disinhibiting]] effects of dissociatives, particularly those without pronounced [[motor control loss|motor suppressing]] components such as [[ketamine]]. The sum of these effects can increase the likelihood of an anxiety attack, delusions or a [[psychosis|psychotic episode]].
+*'''[[DangerousInteraction::Stimulants|Stimulants]]''' (e.g. '''''[[amphetamine]], [[cocaine]], [[methylphenidate]], [[MDMA]]''''') - This combination can potentiate the [[anxiety]]-inducing, [[mania|manic]], [[delusion|delusional]] and [[disinhibition|disinhibiting]] effects of dissociatives, particularly those without pronounced [[motor control loss|motor suppressing]] components such as [[ketamine]]. The sum of these effects can increase the likelihood of an anxiety attack, delusions or a [[psychosis|psychotic episode]]. There is also evidence that suggests that combining these two increases their neurotoxicity.{{citation needed}} Anecdotally, worsened comedowns are also commonly reported when these two classes of substances are combined.
+*'''[[DangerousInteraction::Dissociatives|Dissociatives]]''' (e.g. '''''[[dextromethorphan]], [[ketamine]], [[methoxetamine]], [[PCP]]''''') - Combination can unpredictably potentiate [[amnesia]], [[sedation]], [[motor control loss]] and [[delusions]]. It may also result in a sudden loss of consciousness along with a dangerous amount of [[respiratory depression]]. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
-:Prominent examples include [[PCP]] and its analogs [[3-MeO-PCP]], [[MXE]], and the [[diarylethylamine]] dissociatives like [[diphenidine]] or [[ephenidine]]. There is also evidence that suggests that combining these two increases their neurotoxicity.{{citation needed}} Anecdotally, worsened comedowns are also commonly reported when these two classes of substances are combined.
-*'''[[Dissociatives]]''' - This combination can unpredictably potentiate the [[amnesia]], [[sedation]], [[motor control loss]] and [[delusions]] that can be caused by each other. It may also result in a sudden loss of consciousness accompanied by a dangerous degree of [[respiratory depression]]. If [[nausea]] or vomiting occurs before consciousness is lost, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.