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Amnesia: Difference between revisions

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'''Amnesia''' can be described as an inability to later recall the events which occurred under the influence of a substance after it has worn off.<ref>Amnesia (mayoclinic) | https://www.mayoclinic.org/diseases-conditions/amnesia/symptoms-causes/syc-20353360</ref><ref>Drug-induced memory disturbance (medlink) | http://www.medlink.com/article/drug-induced_memory_disturbance</ref><ref>Veselis, R. A., Reinsel, R. A., & Feshchenko, V. A. (2001). Drug-induced Amnesia Is a Separate Phenomenon from SedationElectrophysiologic Evidence. Anesthesiology: The Journal of the American Society of Anesthesiologists, 95(4), 896-907. https://www.ncbi.nlm.nih.gov/pubmed/11605930</ref> During states of amnesia a person will usually retain a functional long and short-term memory which can still recall events that recently occurred despite those same events failing to be retained in a manner which can later be recalled. As such, a person experiencing amnesia may not obviously appear to be doing so, as they can often carry on normal conversations and perform complex tasks.  
'''Amnesia''' is defined as a global impairment in the ability to acquire new memories regardless of sensory modality, and a loss of some memories, especially recent ones, from the period before amnesia began.<ref name="SquireZola1997">{{cite journal|last1=Squire|first1=L. R.|last2=Zola|first2=S. M.|title=Amnesia, memory and brain systems|journal=Philosophical Transactions of the Royal Society B: Biological Sciences|volume=352|issue=1362|year=1997|pages=1663–1673|issn=0962-8436|doi=10.1098/rstb.1997.0148}}</ref> During states of amnesia a person will usually retain functional perceptual abilities and short-term memory which can still be used to recall events that recently occurred; this effect is distinct from the memory impairment produced by [[sedation]].<ref>{{cite journal | vauthors=((Veselis, R. A.)), ((Reinsel, R. A.)), ((Feshchenko, V. A.)) | journal=Anesthesiology | title=Drug-induced Amnesia Is a Separate Phenomenon from Sedation | volume=95 | issue=4 | pages=896–907 | date=1 October 2001 | url=https://pubs.asahq.org/anesthesiology/article/95/4/896/39144/Druginduced-Amnesia-Is-a-Separate-Phenomenon-from | issn=0003-3022 | doi=10.1097/00000542-200110000-00018}}</ref> As such, a person experiencing amnesia may not obviously appear to be doing so, as they can often carry on normal conversations and perform complex tasks.  


This state of mind is commonly referred to as a "blackout", an experience that can be divided into 2 formal categories: "fragmentary" blackouts and "en bloc" blackouts.<ref>Hartzler, B., & Fromme, K. (2003). Fragmentary and en bloc blackouts: similarity and distinction among episodes of alcohol-induced memory loss. Journal of Studies on Alcohol, 64(4), 547-550. http://dx.doi.org/10.15288/jsa.2003.64.547</ref> Fragmentary blackouts, sometimes known as "brownouts", are characterized by having the ability to recall specific events from an intoxicated period but remaining unaware that certain memories are missing until reminded of the existence of those gaps in memory. Studies suggest that fragmentary blackouts are far more common than "en bloc" blackouts.<ref>White, A. M., Signer, M. L., Kraus, C. L., & Swartzwelder, H. S. (2004). Experiential aspects of alcohol‐induced blackouts among college students. The American journal of drug and alcohol abuse, 30(1), 205-224. https://www.ncbi.nlm.nih.gov/pubmed/15083562</ref> In comparison, En bloc blackouts are characterized by a complete inability to later recall any memories from an intoxicated period, even when prompted. It is usually difficult to determine the point at which this type of blackout has ended as sleep typically occurs before this happens.<ref>Goodwin, D. W., Crane, J. B., & Guze, S. B. (1969). Alcoholic" blackouts": A review and clinical study of 100 alcoholics. American Journal of Psychiatry, 126(2), 191-198. https://doi.org/10.1176/ajp.126.2.191</ref>  
This state of mind is commonly referred to as a "blackout", an experience that can be divided into 2 formal categories: "fragmentary" blackouts and "en bloc" blackouts.<ref name="HartzlerFromme2003">{{cite journal|last1=Hartzler|first1=Bryan|last2=Fromme|first2=Kim|title=Fragmentary and en bloc blackouts: similarity and distinction among episodes of alcohol-induced memory loss.|journal=Journal of Studies on Alcohol|volume=64|issue=4|year=2003|pages=547–550|issn=0096-882X|doi=10.15288/jsa.2003.64.547}}</ref> Fragmentary blackouts, sometimes known as "brownouts", are characterized by having the ability to recall specific events from an intoxicated period but remaining unaware that certain memories are missing until reminded of the existence of those gaps in memory. Studies suggest that fragmentary blackouts are far more common than "en bloc" blackouts.<ref>{{cite journal | vauthors=((White, A. M.)), ((Signer, M. L.)), ((Kraus, C. L.)), ((Swartzwelder, H. S.)) | journal=The American Journal of Drug and Alcohol Abuse | title=Experiential Aspects of Alcohol‐Induced Blackouts Among College Students | volume=30 | issue=1 | pages=205–224 | date=1 January 2004 | url=https://www.tandfonline.com/doi/full/10.1081/ADA-120029874 | doi=10.1081/ADA-120029874}}</ref> In comparison, En bloc blackouts are characterized by a complete inability to later recall any memories from an intoxicated period, even when prompted. It is usually difficult to determine the point at which this type of blackout has ended as sleep typically occurs before this happens.<ref name="GoodwinCrane1969">{{cite journal|last1=Goodwin|first1=Donald W.|last2=Crane|first2=J. Bruce|last3=Guze|first3=Samuel B.|title=Alcoholic "Blackouts": A Review and Clinical Study of 100 Alcoholics|journal=American Journal of Psychiatry|volume=126|issue=2|year=1969|pages=191–198|issn=0002-953X|doi=10.1176/ajp.126.2.191}}</ref>


Amnesia is often accompanied by other coinciding effects such as [[disinhibition]], [[sedation]], and [[memory suppression]]. It is most commonly induced under the influence of [[dosage#heavy|heavy]] [[dosage|dosages]] of [[GABAergic]] [[depressant|depressants]], such as [[alcohol]],<ref>Lee, H., Roh, S., & Kim, D. J. (2009). Alcohol-induced blackout. International Journal of Environmental Research and Public Health, 6(11), 2783-2792. https://dx.doi.org/10.3390%2Fijerph6112783</ref> [[benzodiazepines]],<ref>Mejo, S. L. (1992). Anterograde amnesia linked to benzodiazepines. The Nurse Practitioner, 17(10), 44-49. https://www.ncbi.nlm.nih.gov/pubmed/1357612</ref> [[GHB]],<ref>Barker, J. C., Harris, S. L., & Dyer, J. E. (2007). Experiences of gamma hydroxybutyrate (GHB) ingestion: a focus group study. Journal of psychoactive drugs, 39(2), 115-129. https://dx.doi.org/10.1080%2F02791072.2007.10399870</ref> and [[zolpidem]]<ref>Canaday, B. R. (1996). Amnesia possibly associated with zolpidem administration. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 16(4), 687-689. https://doi.org/10.1002/j.1875-9114.1996.tb03654.x</ref>. However, it can also occur to a much lesser extent under the influence of extremely heavy dosages of [[hallucinogen|hallucinogenic]] compounds such as [[psychedelic|psychedelics]], [[dissociative|dissociatives]], [[Salvia divinorum]], and [[deliriant|deliriants]].
Amnesia is often accompanied by other coinciding effects such as [[disinhibition]], [[sedation]], and [[memory suppression]]. It is most commonly induced under the influence of [[dosage#heavy|heavy]] [[dosage|dosages]] of [[GABAergic]] [[depressant|depressants]], such as [[alcohol]],<ref name="LeeRoh2009">{{cite journal|last1=Lee|first1=Hamin|last2=Roh|first2=Sungwon|last3=Kim|first3=Dai Jin|title=Alcohol-Induced Blackout|journal=International Journal of Environmental Research and Public Health|volume=6|issue=11|year=2009|pages=2783–2792|issn=1660-4601|doi=10.3390/ijerph6112783}}</ref> [[benzodiazepines]],<ref>{{cite journal | vauthors=((Mejo, S. L.)) | journal=The Nurse Practitioner | title=Anterograde Amnesia Linked to Benzodiazepines: | volume=17 | issue=10 | pages=44–50 | date= October 1992 | url=http://journals.lww.com/00006205-199210000-00013 | issn=0361-1817 | doi=10.1097/00006205-199210000-00013}}</ref> [[GHB]],<ref name="BarkerHarris2007">{{cite journal|last1=Barker|first1=Judith C.|last2=Harris|first2=Shana L.|last3=Dyer|first3=Jo E.|title=Experiences of Gamma Hydroxybutyrate (GHB) Ingestion: A Focus Group Study|journal=Journal of Psychoactive Drugs|volume=39|issue=2|year=2007|pages=115–129|issn=0279-1072|doi=10.1080/02791072.2007.10399870}}</ref> and [[zolpidem]]<ref>{{cite journal | vauthors=((Canaday, B. R.)) | journal=Pharmacotherapy | title=Amnesia possibly associated with zolpidem administration | volume=16 | issue=4 | pages=687–689 | date= August 1996 | issn=0277-0008}}</ref>. However, it can also occur to a much lesser extent under the influence of extremely heavy dosages of [[hallucinogen|hallucinogenic]] compounds such as [[psychedelic|psychedelics]], [[dissociative|dissociatives]], [[Salvia divinorum]], and [[deliriant|deliriants]].
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===Psychoactive substances===
===Psychoactive substances===
Compounds within our [[psychoactive substance index]] which may cause this effect include:
Compounds within our [[psychoactive substance index]] which may cause this effect include:
{{#ask:[[Category:Psychoactive substance]][[Effect::Amnesia]]|format=ul|Columns=2}}
{{#ask:[[Category:Psychoactive substance]][[Effect::Amnesia]]|format=ul|Columns=2}}
===Experience reports===
Annectdotal reports which describe this effect with our [[experience index]] include:
{{#ask:[[Category:Experience]][[Effect::Amnesia]]|format=ul|Columns=2}}
===See also===
===See also===
*[[Responsible use]]
*[[Responsible use]]
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* [https://en.wikipedia.org/wiki/Amnesia Amnesia (Wikipedia)]
* [https://en.wikipedia.org/wiki/Amnesia Amnesia (Wikipedia)]
===References===
===References===
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[[Category:Cognitive]] [[Category:Suppression]] [[Category:Effect]]
[[Category:Cognitive]]  
[[Category:Depression]]  
[[Category:Effect]]
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